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Methylpyrazolo[1,5-a]pyridin-3-carboxylat
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Methylpyrazolo[1,5-a]pyridin-3-carboxylat
Artikel-Nr:
(BOSSBS-1687R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1687R-FITC
Lokale Artikelnummer::
BOSSBS-1687R-FITC
Beschreibung:
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-133 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition. Isoform 2 cannot induce apoptosis but can induce membrane blebbing.
VE:
1 * 100 µl
Artikel-Nr:
(APOSBICL4054-1MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
BICL4054-1MG
Lokale Artikelnummer::
APOSBICL4054-1MG
Beschreibung:
Curcumin-4-O-β-D-glucuronide ≥85%
VE:
1 * 1 mg
Artikel-Nr:
(BOSSBS-4609R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4609R-CY7
Lokale Artikelnummer::
BOSSBS-4609R-CY7
Beschreibung:
Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1407R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1407R-A350
Lokale Artikelnummer::
BOSSBS-1407R-A350
Beschreibung:
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6959R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6959R
Lokale Artikelnummer::
BOSSBS-6959R
Beschreibung:
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER alpha and ER beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ER alpha and ER beta A have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER alpha and ER beta may be regulated by distinct mechanisms even though they share many functional characteristics.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4005R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-A555
Lokale Artikelnummer::
BOSSBS-4005R-A555
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4005R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4005R-FITC
Lokale Artikelnummer::
BOSSBS-4005R-FITC
Beschreibung:
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5018R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5018R-HRP
Lokale Artikelnummer::
BOSSBS-5018R-HRP
Beschreibung:
ACADVL (acyl-Coenzyme A dehydrogenase, very long chain) catalyzes the first step of the mitochondrial fatty acid beta-oxidation pathway. It is specific to esters of long-chain and very long chain fatty acids such as palmitoyl-CoA and stearoyl-CoA. Deficiencies in ACADVL are associated with reduced myocardial fatty acid beta-oxidation and cardiomyopathy.
VE:
1 * 100 µl
Artikel-Nr:
(USBI123173)
Lieferant:
US Biological
Hersteller-Artikelnummer::
123173
Lokale Artikelnummer::
USBI123173
Beschreibung:
Anti-AKR1D1 Mouse Monoclonal Antibody [clone: 1C2]
VE:
1 * 100 µG
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Azidoethyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-galactopyranoside ≥98%
Artikel-Nr:
(BOSSBS-1912R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1912R-CY5
Lokale Artikelnummer::
BOSSBS-1912R-CY5
Beschreibung:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3759R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3759R-CY5
Lokale Artikelnummer::
BOSSBS-3759R-CY5
Beschreibung:
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes. S100A4 has been implicated in motility, invasion and tubulin polymerization. It is also involved in tumor metastasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13544R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13544R-CY5
Lokale Artikelnummer::
BOSSBS-13544R-CY5
Beschreibung:
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4532R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4532R
Lokale Artikelnummer::
BOSSBS-4532R
Beschreibung:
Clenbuterol belongs to the group of agonists. In livestock production clenbuterol improves the meat/fat ratio in fattened animals or accelerate the growth. Up to now agonists have not been authorized as adjuvants for fattening. In addition to its lipolytic and anabolic effect, clenbuterol has a relaxing effect on non-striated musculature on which is based its therapeutic use as an antiasthmatic and a tocolytic agent. When employed as a fattening adjuvant, as compared with the therapeutic use, clenbuterol is administered in a 5 to 10 times higher dose. Therefore, it is possible that clenbuterol residues may lead to a risk for consumers after illegal administration.Using the clenbuterol monocalantibody, it is possible to detect clenbuterol and other agonists in urine, muscle and liver both rapidly and with accuracy. Clenbuterol is a long acting beta 2 adrenergic agonist. Like other beta 2 agonists, clenbuterol is believed to act by stimulating production of cyclic AMP through the activation of adenyl cyclase. By definition, Beta 2 agonists have more smooth muscle relaxation activity (bronchial, vascular and uterine smooth muscle) versus its cardiac effects (Beta 1).
VE:
1 * 100 µl
Artikel-Nr:
(USBI036776-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
036776-BIOTIN
Lokale Artikelnummer::
USBI036776-BIOTIN
Beschreibung:
Anti-HSD11B2 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(BSENR-1751-50)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1751-50
Lokale Artikelnummer::
BSENR-1751-50
Beschreibung:
This antibody is a nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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