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Aluminiumoxid,+\u03B3-Phase
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Artikel-Nr:
(BOSSBS-1805R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1805R-CY5.5
Lokale Artikelnummer::
BOSSBS-1805R-CY5.5
Beschreibung:
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Biochemistry, 20, 4530 (1981): anion-pairing agent for reverse phase HPLC purification of proteins & peptides.
Lieferant:
Advanced Chromatography Technologies
Beschreibung:
Avantor® ACE® Methodenentwicklungs-Kits (MDK) für eine optimale Selektivität bieten leistungsstarke, zuverlässige Unterstützung bei der Entwicklung von UHPLC-/HPLC-Methoden. Avantor® ACE® Phasen basieren auf einem ultra-inerten, hocheffizienten Kieselgel und den neuesten Entwicklungen im Design von stationären LC-Phasen, sodass Chromatographie-Spezialisten mehr Auswahlmöglichkeiten für alternative Selektivität ohne Beeinträchtigung der Stabilität oder Robustheit haben.
Artikel-Nr:
(19000-50MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
19000-50MG
Lokale Artikelnummer::
SUPL19000-50MG
Beschreibung:
Monolinuron CRM kann auch wie unten angegeben verwendet werden: Bestimmung von 252 Pestiziden, die aus Oberflächenwasserproben durch Festphasenextraktion (SPE) unter Verwendung von Flüssigchromatographie-Quadrupol-Orbitrap-Tandem-Massenspektrometrie mit hoher Auflösung extrahiert wurden. Extraktion von 13 Pestiziden aus vier Grundwasser- und drei Flusswasserproben unter Verwendung des mesoporösen Feststoffs MSU-1 auf Siliciumdioxidbasis als Sorbens für ihre Festphasenextraktion (SPE), gefolgt von einer Bestimmung mittels Ultra-Performance-Flüssigkeitschromatographie-Triple-Quadrupol-Massenspektrometrie (UHPLC-QqQ-MS/MS). Entwicklung und Validierung einer UHPLC-Diodenarray-Detektionsmethode (DAD) zur gleichzeitigen Bestimmung von Harnstoff- und Tebuthiuron-Herbiziden in vier frischen Gemüseproben. Multirückstandsanalyse von 50 Herbiziden in 51 Getreideproben von Soja, Mais und Weizen mittels Ultra-Performance-Flüssigkeitschromatographie-Elektrospray-Ionisations-Massenspektrometrie (UPLC-ESI-MS). Extraktion von 109 Pestizidrückständen verschiedener chemischer Klassen aus 345 Tomatenproben mittels modifizierter QuEChERS-Methode und deren Bestimmung mittels Flüssigkeitschromatographie-Tandem-Massenspektrometrie (LC-MS/MS). Gleichzeitige Analyse von 238 Pestiziden und 78 Tierarzneimitteln in 80 Kuhmilchproben mittels ultraschneller Flüssigkeitschromatographie-Tandem-Massenspektrometrie (UFLC-MS/MS) und Gaschromatographie-Tandem-Massenspektrometrie (GC-MS/MS).
VE:
1 * 50 mg
Artikel-Nr:
(BOSSBS-0757R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0757R-HRP
Lokale Artikelnummer::
BOSSBS-0757R-HRP
Beschreibung:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a protein of 54 kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a protein of 54 kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.
Artikel-Nr:
(BOSSBS-2969R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2969R-CY5.5
Lokale Artikelnummer::
BOSSBS-2969R-CY5.5
Beschreibung:
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2969R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2969R-HRP
Lokale Artikelnummer::
BOSSBS-2969R-HRP
Beschreibung:
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4184R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4184R
Lokale Artikelnummer::
BOSSBS-4184R
Beschreibung:
p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5981R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5981R-CY5
Lokale Artikelnummer::
BOSSBS-5981R-CY5
Beschreibung:
p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Lieferant:
Biotium
Beschreibung:
Cyclins, regulatory subunits, which associate with kinases, control many of the important steps in cell cycle progression. The Cdc2 protein kinase (p34Cdc2) exhibits protein kinase activity in vitro and exists in a complex with both cyclin B and a protein homologous to p13SUC1. Cdc2 kinase is the active subunit of the M phase promoting factor (MPF) and the M phase-specific Histone H1 kinase. The p34Cdc2/cyclin B complex is required for the G2 to M transition. An additional cell cycle-dependent protein kinase, termed p55cdc, exhibits a high degree of homology with the S. cerevisiae proteins Cdc20 and Cdc4. The p55cdc transcript is readily detectable in a variety of cultured cell lines in growth phase, but disappears when cell growth is chemically arrested.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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