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Artikel-Nr: (BOSSBS-6138R)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-6138R
Lokale Artikelnummer:: BOSSBS-6138R
Beschreibung: EID1 ia an acetyltransferase enzyme. It acetylates histones, giving a specific tag for transcriptional activation. EID1 also acetylates non histone proteins, like NCOA3 coactivator. It Mediates cAMP gene regulation by binding specifically to phosphorylated CREB protein and as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP responsive genes.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3921R-A647)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3921R-A647
Lokale Artikelnummer:: BOSSBS-3921R-A647
Beschreibung: The ADCY4 gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3921R-A750)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3921R-A750
Lokale Artikelnummer:: BOSSBS-3921R-A750
Beschreibung: The ADCY4 gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyse the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-9477R-HRP)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-9477R-HRP
Lokale Artikelnummer:: BOSSBS-9477R-HRP
Beschreibung: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-9477R-FITC)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-9477R-FITC
Lokale Artikelnummer:: BOSSBS-9477R-FITC
Beschreibung: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-9477R-A647)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-9477R-A647
Lokale Artikelnummer:: BOSSBS-9477R-A647
Beschreibung: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-2985R)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-2985R
Lokale Artikelnummer:: BOSSBS-2985R
Beschreibung: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3916R-CY7)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3916R-CY7
Lokale Artikelnummer:: BOSSBS-3916R-CY7
Beschreibung: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-1807R-CY5)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-1807R-CY5
Lokale Artikelnummer:: BOSSBS-1807R-CY5
Beschreibung: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3969R-A647)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3969R-A647
Lokale Artikelnummer:: BOSSBS-3969R-A647
Beschreibung: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3969R-HRP)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3969R-HRP
Lokale Artikelnummer:: BOSSBS-3969R-HRP
Beschreibung: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-4022R-A750)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-4022R-A750
Lokale Artikelnummer:: BOSSBS-4022R-A750
Beschreibung: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-4022R-HRP)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-4022R-HRP
Lokale Artikelnummer:: BOSSBS-4022R-HRP
Beschreibung: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-4022R-FITC)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-4022R-FITC
Lokale Artikelnummer:: BOSSBS-4022R-FITC
Beschreibung: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
VE: 1 * 100 µl


Artikel-Nr: (BOSSBS-3964R-CY5)
Lieferant: Bioss
Hersteller-Artikelnummer:: BS-3964R-CY5
Lokale Artikelnummer:: BOSSBS-3964R-CY5
Beschreibung: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
VE: 1 * 100 µl


Artikel-Nr: (390-1593)
Lieferant: VWR Collection
Lokale Artikelnummer:: VWRI390-1593
Beschreibung: CO₂ Ersatzgasfilter , Für: ILCO 180 Premium
VE: 1 * 1 ST


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