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cis-7-Cbz-3,7-diazabicyclo[4.2.0]octane
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cis-7-Cbz-3,7-diazabicyclo[4.2.0]octane
Artikel-Nr:
(BOSSBS-10465R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10465R-CY7
Lokale Artikelnummer::
BOSSBS-10465R-CY7
Beschreibung:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11690R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11690R
Lokale Artikelnummer::
BOSSBS-11690R
Beschreibung:
FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking. Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), both of which negatively affect the nervous system. CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration. Unlike CMT4J, ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, causing paralysis and, ultimately, death.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10465R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10465R-CY5
Lokale Artikelnummer::
BOSSBS-10465R-CY5
Beschreibung:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11390R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11390R-A750
Lokale Artikelnummer::
BOSSBS-11390R-A750
Beschreibung:
AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase), also known as LYS2, LYS5 or CGI-80, is a 309 amino acid protein that localizes to the cytoplasm and belongs to the P-Pant transferase superfamily. Expressed in testis, liver, kidney, heart, brain, placenta and skeletal muscle, AASDHPPT exists as a monomer that functions to catalyse the phosphopantetheine-dependent post-translational modification of target proteins, effectively transferring a 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of an acceptor protein. AASDHPPT is subject to DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding AASDHPPT maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3333R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3333R-A680
Lokale Artikelnummer::
BOSSBS-3333R-A680
Beschreibung:
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3531R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3531R-FITC
Lokale Artikelnummer::
BOSSBS-3531R-FITC
Beschreibung:
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3531R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3531R-A750
Lokale Artikelnummer::
BOSSBS-3531R-A750
Beschreibung:
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
4-Nitrophthalonitril 99%
Artikel-Nr:
(525-0183)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI525-0183
Beschreibung:
PTFE, glatte Oberfläche, mit oder ohne Schraubkappe.
VE:
1 * 1 ST
Lieferant:
Alfa Aesar
Beschreibung:
Samarium ≥99,9% (REO, Basis der Oxide der Metalle der seltenen Erden), Stücke ≤ 12 mm (0.47 in)
Artikel-Nr:
(CAYM11004-1)
Lieferant:
Cayman Chemical
Hersteller-Artikelnummer::
11004-1
Lokale Artikelnummer::
CAYM11004-1
Beschreibung:
Anti-PDPN Rat Monoclonal Antibody [clone: NZ-1.2]
VE:
1 * 1 ST
Artikel-Nr:
(USBIM2362-50B-BIOT)
Lieferant:
US Biological
Hersteller-Artikelnummer::
M2362-50B-BIOT
Lokale Artikelnummer::
USBIM2362-50B-BIOT
Beschreibung:
Anti-MAP Kinase 12 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-11062R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11062R-A680
Lokale Artikelnummer::
BOSSBS-11062R-A680
Beschreibung:
CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and Signalling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5564R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5564R-CY7
Lokale Artikelnummer::
BOSSBS-5564R-CY7
Beschreibung:
Protein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11062R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11062R-A750
Lokale Artikelnummer::
BOSSBS-11062R-A750
Beschreibung:
CYTIP is a cytoplasmic protein that is involved in lymphocytic cell adhesion. Expressed primarily in hematopoetic cells, CYTIP regulates the activity of cytohesin-1 (an integrin-activating protein involved in cell adhesion) by mediating its recruitment to the leukocyte membrane. Through its ability to bind cytohesin-1, CYTIP is able to sequester it to the cytoplasm, thereby preventing cytohesin-1 translocation to lymphocytes and interrupting the flow of information in the cell adhesion pathway. CYTIP can be recruited from the cytoplasm to the membrane by leukocyte integrins which interact with CYTIP through its PDZ domain. After membrane translocation, CYTIP can be re-located to the cytoplasm via exposure to a phorbol ester. Additionally, CYTIP associates with SNX27 (sorting nexin 27) and helps to coordinate trafficking and Signalling complexes. Up-regulation of CYTIP is observed in maturing dendritic cells, suggesting a possible role in developmentally-controlled cell adhesion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5564R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5564R-A750
Lokale Artikelnummer::
BOSSBS-5564R-A750
Beschreibung:
Protein kinase C (PKC) is a family of serine and threonine specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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