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H-Tyr(BZL)-OMe·HCl
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H-Tyr(BZL)-OMe·HCl
Artikel-Nr:
(BOSSBS-1764R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1764R-A680
Lokale Artikelnummer::
BOSSBS-1764R-A680
Beschreibung:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1764R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1764R-A350
Lokale Artikelnummer::
BOSSBS-1764R-A350
Beschreibung:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-CY5
Lokale Artikelnummer::
BOSSBS-1135R-CY5
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI79-936)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-936
Lokale Artikelnummer::
PRSI79-936
Beschreibung:
Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion
VE:
1 * 100 µG
Artikel-Nr:
(PHR1685-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
PHR1685-1G
Lokale Artikelnummer::
SUPLPHR1685-1G
Beschreibung:
Organic Standard, Fexofenadine HCl
VE:
1 * 1 g
Artikel-Nr:
(1.15186.1000)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.15186.1000
Lokale Artikelnummer::
MERC1.15186.1000
Beschreibung:
Salzsäure 36%, Supelco®
VE:
1 * 1 L
Lieferant:
Merck
Beschreibung:
Cysteaminiumchlorid zur Synthese, Sigma-Aldrich®
Artikel-Nr:
(60HYD20252)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC60HYD20252
Beschreibung:
Salzsäure verdünnt (60 ml dosed with 1 ml 37% HCl)
VE:
1 * 96 ST
Lieferant:
PanReac AppliChem
Beschreibung:
TRIS HCl (Tris(hydroxymethyl)aminomethan Hydrochlorid)
Lieferant:
Merck
Beschreibung:
N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimid Hydrochlorid zur Synthese
Artikel-Nr:
(BLDPBD00858192-250)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD00858192-250
Lokale Artikelnummer::
BLDPBD00858192-250
Beschreibung:
2-(5-BROMO-2-FLUOROPHENYL)PYRROLIDINE HCL 95%
VE:
1 * 250 mg
Lieferant:
Merck
Beschreibung:
Salzsäure 32%, Supelco®
Artikel-Nr:
(2081-07)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKR2081-07
Beschreibung:
L(+)-Histidin Hydrochlorid Monohydrat, Multikompendial, J.T.Baker®
VE:
1 * 12 kg
Lieferant:
Alfa Aesar
Beschreibung:
TRIS HCl (Tris(hydroxymethyl)aminomethan Hydrochlorid) ≥99%
Lieferant:
Sigma-Aldrich
Beschreibung:
Chlorwasserstoff 1.25 mol/l in Methanol, Supelco®
Lieferant:
Alfa Aesar
Beschreibung:
H-Glu(OtBu)-OtBu·HCl 98%
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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