Suche >
INTEGRATED+DNA+TECHNOLOGIE
Drucken
Sie suchten nach:
37 214 results were found
INTEGRATED+DNA+TECHNOLOGIE
Artikel-Nr:
(BOSSBS-0660R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0660R
Lokale Artikelnummer::
BOSSBS-0660R
Beschreibung:
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1148R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1148R-A555
Lokale Artikelnummer::
BOSSBS-1148R-A555
Beschreibung:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9077R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9077R-FITC
Lokale Artikelnummer::
BOSSBS-9077R-FITC
Beschreibung:
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Specifically, Cdk2 interacts with Cyclins A, B1, B3, D, or E to control cell cycle progression. The Cyclin-dependent kinase 2-interacting protein (CINP) interacts with components of the replication complex and Cdk2 and Cdc7, thereby providing a functional and physical link between Cdk2 and Cdc7 during firing of the origins of replication. However, CINP is phopshorylated by Cdc7, but not by Cdk2. CINP also interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress and G2 checkpoint integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11387R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11387R-A488
Lokale Artikelnummer::
BOSSBS-11387R-A488
Beschreibung:
AADACL4 is a 407 amino acid single-pass type II membrane protein belonging to the 'GDXG' lipolytic enzyme family. Integral to the cell membrane, AADACL4 participates in carboxylesterase and hydrolase activities and is encoded by a gene that maps to human chromosome 1p36.22. Chromosome 1, the largest human chromosome, makes up 8% of the human genome and contains about 260 million base pairs, which encode 3,000 genes. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11387R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11387R-FITC
Lokale Artikelnummer::
BOSSBS-11387R-FITC
Beschreibung:
AADACL4 is a 407 amino acid single-pass type II membrane protein belonging to the 'GDXG' lipolytic enzyme family. Integral to the cell membrane, AADACL4 participates in carboxylesterase and hydrolase activities and is encoded by a gene that maps to human chromosome 1p36.22. Chromosome 1, the largest human chromosome, makes up 8% of the human genome and contains about 260 million base pairs, which encode 3,000 genes. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11553R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11553R-A350
Lokale Artikelnummer::
BOSSBS-11553R-A350
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0693R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0693R-FITC
Lokale Artikelnummer::
BOSSBS-0693R-FITC
Beschreibung:
The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11759R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11759R-CY5
Lokale Artikelnummer::
BOSSBS-11759R-CY5
Beschreibung:
Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10% of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40%.
VE:
1 * 100 µl
Lieferant:
Tonbo Biosciences
Beschreibung:
The SK7 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
Lieferant:
VWR Collection
Beschreibung:
Halbmikrowaagen mit einer Auflösung von 0,01 mg, ausgestattet mit einer neuen hochintegrierten elektromagnetischen Zelle. Alle Modelle verfügen über eine automatische interne Kalibrierung und zeichnen sich durch ein hohes Maß an Präzision und Wiederholbarkeit aus. Diese Halbmikrowaagen von VWR® bieten dank kontinuierlicher intensiver Forschung und Untersuchung der Funktionsweise des Wiegens ein hervorragendes Preis-Leistungs-Verhältnis. Alle Modelle verfügen über eine Oberschale aus Edelstahl.
Artikel-Nr:
(BOSSBS-9705R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9705R-FITC
Lokale Artikelnummer::
BOSSBS-9705R-FITC
Beschreibung:
The type II integral membrane (ITM2) protein family consists of three members ITM2A (also designated E25), ITM2B and ITM2C. ITM2A expression is high in osteogenic and lymphoid tissues, while both ITM2B and ITM2C are expressed in brain. Mutations in the ITM2B gene can lead to familial British dementia (fbd), and autosomal dominant disease characterized by progressive dementia, spasticity, and cerebellar ataxia, or familial Danish dementia (fdd), an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia, and dementia. The ITM2A 263-amino acid protein contains an N-terminal cytosolic domain, an uncleaved signal anchor sequence, and a tyrosine-rich C-terminal domain. Human ITM2A shares 91% homology with mouse ITM2A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9705R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9705R-HRP
Lokale Artikelnummer::
BOSSBS-9705R-HRP
Beschreibung:
The type II integral membrane (ITM2) protein family consists of three members ITM2A (also designated E25), ITM2B and ITM2C. ITM2A expression is high in osteogenic and lymphoid tissues, while both ITM2B and ITM2C are expressed in brain. Mutations in the ITM2B gene can lead to familial British dementia (fbd), and autosomal dominant disease characterized by progressive dementia, spasticity, and cerebellar ataxia, or familial Danish dementia (fdd), an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia, and dementia. The ITM2A 263-amino acid protein contains an N-terminal cytosolic domain, an uncleaved signal anchor sequence, and a tyrosine-rich C-terminal domain. Human ITM2A shares 91% homology with mouse ITM2A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9705R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9705R-CY7
Lokale Artikelnummer::
BOSSBS-9705R-CY7
Beschreibung:
The type II integral membrane (ITM2) protein family consists of three members ITM2A (also designated E25), ITM2B and ITM2C. ITM2A expression is high in osteogenic and lymphoid tissues, while both ITM2B and ITM2C are expressed in brain. Mutations in the ITM2B gene can lead to familial British dementia (fbd), and autosomal dominant disease characterized by progressive dementia, spasticity, and cerebellar ataxia, or familial Danish dementia (fdd), an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia, and dementia. The ITM2A 263-amino acid protein contains an N-terminal cytosolic domain, an uncleaved signal anchor sequence, and a tyrosine-rich C-terminal domain. Human ITM2A shares 91% homology with mouse ITM2A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9705R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9705R-CY3
Lokale Artikelnummer::
BOSSBS-9705R-CY3
Beschreibung:
The type II integral membrane (ITM2) protein family consists of three members ITM2A (also designated E25), ITM2B and ITM2C. ITM2A expression is high in osteogenic and lymphoid tissues, while both ITM2B and ITM2C are expressed in brain. Mutations in the ITM2B gene can lead to familial British dementia (fbd), and autosomal dominant disease characterized by progressive dementia, spasticity, and cerebellar ataxia, or familial Danish dementia (fdd), an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia, and dementia. The ITM2A 263-amino acid protein contains an N-terminal cytosolic domain, an uncleaved signal anchor sequence, and a tyrosine-rich C-terminal domain. Human ITM2A shares 91% homology with mouse ITM2A.
VE:
1 * 100 µl
Lieferant:
bimos
Beschreibung:
Neben speziellen Hygieneeigenschaften muss ein Laborstuhl stets an wechselnden Aufgabenorten zur Benutzung zur Verfügung stehen. Er sollte minimalen Raum einnehmen und dennoch maximale Ergonomie und Sitzkomfort bieten, damit präzises und konzentriertes Arbeiten über längere Zeit möglich ist. Form und Funktion von Labster sind perfekt auf die tägliche Praxis im Labor abgestimmt.
Artikel-Nr:
(ACE-109-05005S)
Lieferant:
Advanced Chromatography Technologies
Lokale Artikelnummer::
ACETACE-109-05005S
Beschreibung:
Die Avantor® ACE® C18-AR-Phase nutzt einen speziell entwickelten Liganden, der eine C18-Kette mit integraler Phenylfunktionalität kombiniert und so die Vorteile von C18- und Phenyleigenschaften in einer einzigen Phase vereint. Dies kann für „standardmäßige“ C18-Säulentrennungen verwendet werden, wird aber zusätzlich für Trennungen empfohlen, bei denen Verbindungen mit aromatischer Funktionalität beteiligt sind.
VE:
1 * 1 ST
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
