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Artikel-Nr:
(BOSSBS-5560R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5560R-A680
Lokale Artikelnummer::
BOSSBS-5560R-A680
Beschreibung:
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11756R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11756R-FITC
Lokale Artikelnummer::
BOSSBS-11756R-FITC
Beschreibung:
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the accumulation of either GAGs (glycosaminoglycans) or sulfolipids. Sulfamidase, also known as HSS, SFMD, MPS3A or SGSH, is a 502 amino acid lysosome that belongs to the sulfatase family. It has been suggested that sulfamidase may be involved in the lysosomal degradation of heparan sulfate. Defects in the gene encoding sulfamidase are the cause of Sanfilippo syndrome A, an autosomal recessive lysosomal storage disease caused by impaired degradation of heparan sulfate. Sanfilippo syndrome A is characterized by severe central nervous system degeneration but relatively mild somatic manifestations.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15186R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15186R-A488
Lokale Artikelnummer::
BOSSBS-15186R-A488
Beschreibung:
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD01418026-1G)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01418026-1G
Lokale Artikelnummer::
BLDPBD01418026-1G
Beschreibung:
(1R,2R)-1,2-Bis((S)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)cyclohexane 97%
VE:
1 * 1 g
Lieferant:
VWR Collection
Beschreibung:
Schaumstoffeinsatz, erfordert Universalhalterung, Für: 34 Röhrchen, 12 - 13 mm Ø
Artikel-Nr:
(BOSSBS-12405R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12405R
Lokale Artikelnummer::
BOSSBS-12405R
Beschreibung:
Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl-2 and caspase-3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK 3 gene maps to chromosome 15q21.2 and encodes a 721 amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12405R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12405R-CY5
Lokale Artikelnummer::
BOSSBS-12405R-CY5
Beschreibung:
Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl-2 and caspase-3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK 3 gene maps to chromosome 15q21.2 and encodes a 721 amino acid protein.
VE:
1 * 100 µl
Artikel-Nr:
(ACRO436170250)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
436170250
Lokale Artikelnummer::
ACRO436170250
Beschreibung:
4-(Hydroxymethyl)-1,3-dioxolan-2-on 90%
VE:
1 * 25 g
Artikel-Nr:
(BOSSBS-12071R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12071R-CY5
Lokale Artikelnummer::
BOSSBS-12071R-CY5
Beschreibung:
P2Y purinoceptor 11 (P2Y11) is a 374 amino acid protein belonging to the G-protein coupled receptor one family. P2Y11 is a multi-pass cell membrane protein that acts as a receptor for both ATP and ATD coupled to G proteins. Due to these interactions, P2Y11 is involved in phosphatidylinositol-calcium and adenylyl cyclase pathways. Induced by DMSO and retinoic acid, P2Y11 is highly expressed in spleen tissue. A putative trans-splicing event involving the gene that encodes P2Y11 and an upstream gene encoding PPAN has been found to result in a fusion protein, designated PPAN-P2RY11.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0486R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0486R-CY3
Lokale Artikelnummer::
BOSSBS-0486R-CY3
Beschreibung:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0486R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0486R-CY5
Lokale Artikelnummer::
BOSSBS-0486R-CY5
Beschreibung:
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
VE:
1 * 100 µl
Artikel-Nr:
(APOSOR33183-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR33183-1G
Lokale Artikelnummer::
APOSOR33183-1G
Beschreibung:
(2E)-1-{6-Chloro-2-methylimidazo[1,2-a]pyridin-3-yl}-3-(dimethylamino)prop-2-en-1-one, tech
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD240593-250MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD240593-250MG
Lokale Artikelnummer::
BLDPBD240593-250MG
Beschreibung:
(3aS,8aR)-3,3a,8,8a-Tetrahydro-2H-indeno[1,2-d]oxazol-2-one 95+%
VE:
1 * 250 mg
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
5-Bromo-1-(3-fluorobenzyl)-2-oxo-1,2-dihydro-3-pyridine carboxylic acid
Artikel-Nr:
(17031-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
17031-1G
Lokale Artikelnummer::
SUPL17031-1G
Beschreibung:
3-Hydroxybenzaldehydazin, Supelco®
VE:
1 * 1 g
Lieferant:
Merck
Beschreibung:
Cumarin zur Synthese, Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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