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N-Methyl-N-[2-(4-methylphenoxy)benzyl]amine
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N-Methyl-N-[2-(4-methylphenoxy)benzyl]amine
Artikel-Nr:
(BOSSBS-0483R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0483R-A555
Lokale Artikelnummer::
BOSSBS-0483R-A555
Beschreibung:
Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely via acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1Alpha/Beta. The enzymes responsible for H3K9me3 formation are SUV39H1 and SUV39H2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13345R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13345R-CY7
Lokale Artikelnummer::
BOSSBS-13345R-CY7
Beschreibung:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6216R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6216R-CY7
Lokale Artikelnummer::
BOSSBS-6216R-CY7
Beschreibung:
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity)
VE:
1 * 100 µl
Artikel-Nr:
(SUPL01829-1ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
01829-1ML
Lokale Artikelnummer::
SUPL01829-1ML
Beschreibung:
Ready to use certified reference material mixture suitable for dentification and quantification of extractables and Leachables by GC. 14 components in a concentration of 50 μg/mL.
VE:
1 * 1 mL
Lieferant:
VWR Chemicals
Beschreibung:
Die qualitativ hochwertigen CCS-Viskositätsstandards sind ideal für die Kalibrierung und Verifizierung von Cold-Cranking-Simulatoren.
Artikel-Nr:
(24704.298)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC24704.298
Beschreibung:
Hydrochinon ≥99%, GPR RECTAPUR®
VE:
1 * 1 kg
Artikel-Nr:
(BOSSBS-12330R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12330R-CY7
Lokale Artikelnummer::
BOSSBS-12330R-CY7
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. Staf-50 (50 kDa-stimulated trans-acting factor), also known as TRIM22 (tripartite motif-containing 22), RNF94 or GPSTAF50, is a 498 amino acid cytoplasmic protein that belongs to the TRIM family and, characteristic of TRIM family members, contains one RING-type zinc finger, one B box-type zinc finger and one SPRY domain. Induced by IFN-å and IFN-∫, Staf-50 is strongly expressed in ovary, spleen, thymus and peripheral blood leukocytes where it is thought to mediate the antiviral effects of IFN proteins. Additionally, Staf-50 is present in leukemic cells, suggesting a role in cancer formation and metastasis. Staf-50 exists as two alternatively spliced isoforms which are encoded by a gene that maps to human chromosome 11.
VE:
1 * 100 µl
Lieferant:
FLUOROCHEM
Beschreibung:
2,3,5-Trifluorzimtsäure
Artikel-Nr:
(201-0027)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI201-0027
Beschreibung:
PTFE, 0,05 mm stark.
VE:
1 * 10 ST
Artikel-Nr:
(F781-05)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKRF781-05
Beschreibung:
Dithiothreitol (DTT, Cleland's Reagenz) ≥99,0%, Biotechreagenz, J.T.Baker®
VE:
1 * 1 kg
Artikel-Nr:
(USBI126214)
Lieferant:
US Biological
Hersteller-Artikelnummer::
126214
Lokale Artikelnummer::
USBI126214
Beschreibung:
Anti-EHHADH Mouse Polyclonal Antibody
VE:
1 * 50 µG
Lieferant:
VWR Chemicals
Beschreibung:
Da dieses Produkt nicht stabilisiert ist, nimmt der Gehalt während der Lagerung ab.
Artikel-Nr:
(USBI042700)
Lieferant:
US Biological
Hersteller-Artikelnummer::
042700
Lokale Artikelnummer::
USBI042700
Beschreibung:
Anti-TCF7L2 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-13345R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13345R-HRP
Lokale Artikelnummer::
BOSSBS-13345R-HRP
Beschreibung:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Artikel-Nr:
(BOSSBS-11292R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11292R-HRP
Lokale Artikelnummer::
BOSSBS-11292R-HRP
Beschreibung:
The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. HOX genes that occupy the same relative position along the 5’ to 3’ coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent HOX genes on the same chromosome. HoxA3, in conjunction with Pax1, mediates the development of the thymus, parathyroid gland, and carotid body. Its expression in the third pharyngeal arch and pouch is required for development of the third arch artery, and homozygous null HoxA3 mutants lack the carotid body. HoxA3 also regulates hindbrain development by controlling the axon projection pattern of motor neurons and sensory neurons of the proximal and distal ganglia.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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