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4-(1,3-Oxazol-5-yl)phenol
Artikel-Nr:
(BOSSBS-5915R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-FITC
Lokale Artikelnummer::
BOSSBS-5915R-FITC
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Artikel-Nr:
(BLDPBD333817-100MG)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD333817-100MG
Lokale Artikelnummer::
BLDPBD333817-100MG
Beschreibung:
2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 95%
VE:
1 * 100 mg
Artikel-Nr:
(ACRO148360010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
148360010
Lokale Artikelnummer::
ACRO148360010
Beschreibung:
2-Acetylamino-4-methylthiazole-5-sulphonyl chloride 97%
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
MAPK/ERK Signalling Pathway
Lieferant:
Thermo Scientific
Beschreibung:
Meloxicam 99-101%
Lieferant:
Thermo Scientific
Beschreibung:
Iodmethan 2 M in tert-Butylmethylether, AcroSeal™
Lieferant:
Thermo Scientific
Beschreibung:
CAS No.: 5680-80-8
Artikel-Nr:
(BOSSBS-5915R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5915R-A680
Lokale Artikelnummer::
BOSSBS-5915R-A680
Beschreibung:
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalise with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both <i>in vivo</i> and <i>in vitro</i>. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
(Methylsulfonyl)benzol ≥98%
Artikel-Nr:
(BOSSBS-0301R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0301R-CY5
Lokale Artikelnummer::
BOSSBS-0301R-CY5
Beschreibung:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.
VE:
1 * 100 µl
Artikel-Nr:
(A13002.14)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
A13002.14
Lokale Artikelnummer::
ALFAA13002.14
Beschreibung:
3-Nitro-o-kresol 96%
VE:
1 * 25 g
Artikel-Nr:
(H35310.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
H35310.03
Lokale Artikelnummer::
ALFAH35310.03
Beschreibung:
Methylimidazo[1,2-a]pyridin-7-carboxylat 95%
VE:
1 * 1 g
Artikel-Nr:
(APOSOR302172-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR302172-5G
Lokale Artikelnummer::
APOSOR302172-5G
Beschreibung:
2-Hydroxy-5-nitro-6-picolin
VE:
1 * 5 g
Lieferant:
Sigma-Aldrich
Beschreibung:
Reagent for spectrophotometric determination of metal ions
Artikel-Nr:
(APOSOR30479-5G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR30479-5G
Lokale Artikelnummer::
APOSOR30479-5G
Beschreibung:
2-Bromthioanisol
VE:
1 * 5 g
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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