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Quecksilber(II)trifluormethansulfonat
Artikel-Nr:
(PRSI25-996)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-996
Lokale Artikelnummer::
PRSI25-996
Beschreibung:
FOLH1 is a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. A mutation in the gene encoding FOLH1 may be associated with impaired intestinal absorption of dietary folates.It is used as an effective diagnostic and prognostic indicator of prostate cancer.This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-134)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-134
Lokale Artikelnummer::
PRSI92-134
Beschreibung:
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). CASP10 cleaves and activates caspases 3 and 7, but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6959)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6959
Lokale Artikelnummer::
PRSI6959
Beschreibung:
CLEC2A Antibody: CLEC2A (C-type lectin domain family 2 member A), also known as PILAR (proliferation-induced lymphocyte-associated receptor) is involved in modulating T-cell expansion. It is a 32 kDa single-pass type II membrane protein that contains one C-type lectin domain in its extracellular region and belongs to the CTL/CTLD superfamily. CLEC2A is mainly expressed in skin and highly expressed in CD8(+), B lymphocytes and naive CD4(+) T cells. Manipulation of CLEC2A signaling may be important for treatment of autoimmune diseases and cancer.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI76-331)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-331
Lokale Artikelnummer::
PRSI76-331
Beschreibung:
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI33-951)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-951
Lokale Artikelnummer::
PRSI33-951
Beschreibung:
Arginase catalyses the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterised by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [RefSeq].
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI50-270)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-270
Lokale Artikelnummer::
PRSI50-270
Beschreibung:
Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI6095)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6095
Lokale Artikelnummer::
PRSI6095
Beschreibung:
ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-444)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-444
Lokale Artikelnummer::
PRSI92-444
Beschreibung:
Transforming growth factor beta 3(TGFB3) is a member of a TGF - beta superfamily which is defined by theirstructural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset ofintegrins. It binds with high affinity to TGF- beta RII, a type II serine/threonine kinase receptor. TGFB3 is involved incell differentiation, embryogenesis and development.It is believed to regulate molecules involved in cellularadhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF- beta 3,mammals develop a deformity known as a cleft palate.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-773)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-773
Lokale Artikelnummer::
PRSI91-773
Beschreibung:
Bone Marrow Stromal Antigen 2 (BST2) is a single-pass type II membrane protein that belongs to the tetherin family. BST2 is predominantly expressed in the liver, lung, heart and placenta. BST2 is involved in the sorting of secreted proteins. BST2 is a human cellular protein which inhibits retrovirus infection by preventing the diffusion of virus particles after budding from infected cells. BST2 is initially discovered as an inhibitor to HIV-1 infection in the absence of Vpu, it has also been shown to inhibit the release of other viruses such as retroviruses, filoviruses, arenaviruses, and herpes viruses. BST2 may play a role in B-cell activation in rheumatoid arthritis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-577)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-577
Lokale Artikelnummer::
PRSI76-577
Beschreibung:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
VE:
1 * 0,5 mg
New Product
Artikel-Nr:
(PRSI7467)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7467
Lokale Artikelnummer::
PRSI7467
Beschreibung:
The endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1), a member of the peptidase M1 family, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). It is also designated as adipocyte-derived leucine aminopeptidase (A-LAP), puromycin-insensitive leucine-specific aminopeptidase (PILS-AP) and aminopeptidase regulator of TNFR1 shedding (ARTS-1). ERAP1 is localized to the lumen of the ER and induced by interferon. It may be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI76-841)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-841
Lokale Artikelnummer::
PRSI76-841
Beschreibung:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gamma delta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI76-834)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-834
Lokale Artikelnummer::
PRSI76-834
Beschreibung:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, gamma delta TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI76-769)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-769
Lokale Artikelnummer::
PRSI76-769
Beschreibung:
The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.
VE:
1 * 100 Tests
New Product
Lieferant:
Sartorius
Beschreibung:
The arium® advance EDI provides Type 2 water in consistently high quality. The innovative iJust makes the best use of environmental resources by automatically optimizing water consumption. Unlike conventional water purification systems, the unique display with touch functions in combination with the intuitive menu navigation ensures easy operation.
Artikel-Nr:
(VACU20744300)
Lieferant:
VACUUBRAND
Hersteller-Artikelnummer::
20744300
Lokale Artikelnummer::
VACU20744300
Beschreibung:
This four-stage chemistry-design diaphragm pump is an excellent solution for continuous, oil-free pumping of corrosive gases and vapors and meet highest requirements. The four-stage design of the eight-cylinder pump MV 10C NT provides the advantageous combination of high pumping speed and very low ultimate vacuum of 0,9 mbar in a very compact design. All internal parts in contact with pumped media are made of chemically resistant fluoroplastics. Well-proven PTFE sandwich diaphragms increase reliability and extend operating life.
VE:
1 * 1 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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