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Artikel-Nr:
(BOSSBS-6170R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6170R-CY5
Lokale Artikelnummer::
BOSSBS-6170R-CY5
Beschreibung:
RALA, resorcylic acid lactone alpha, is a low molecular weight GTP binding protein belonging to the RAS family of onco proteins. RALA has a 50% amino acid homology with RAS and an 85% homology with RALB. GTP binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0267R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0267R-CY5
Lokale Artikelnummer::
BOSSBS-0267R-CY5
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1719R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1719R-A750
Lokale Artikelnummer::
BOSSBS-1719R-A750
Beschreibung:
Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 16 and 18 seem to be responsible for the development of some carcinoma like cervical carcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8327R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8327R
Lokale Artikelnummer::
BOSSBS-8327R
Beschreibung:
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4059R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4059R-A350
Lokale Artikelnummer::
BOSSBS-4059R-A350
Beschreibung:
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5789R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5789R-HRP
Lokale Artikelnummer::
BOSSBS-5789R-HRP
Beschreibung:
Zn(2+) acts as a agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated mainly through G(q)-alpha and G(12)/G(13) proteins. Involved in regulation of body weight, gastrointestinal mobility, hormone secretion and cell death (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1065R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1065R-A488
Lokale Artikelnummer::
BOSSBS-1065R-A488
Beschreibung:
May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7754R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7754R-HRP
Lokale Artikelnummer::
BOSSBS-7754R-HRP
Beschreibung:
Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5095R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5095R-HRP
Lokale Artikelnummer::
BOSSBS-5095R-HRP
Beschreibung:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1494R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1494R-HRP
Lokale Artikelnummer::
BOSSBS-1494R-HRP
Beschreibung:
Cytokeratins are a subfamily of intermediate filament proteins and are characterised by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa. The individual cytokeratin polypeptides are designated 1 to 20.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8128R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8128R-CY5
Lokale Artikelnummer::
BOSSBS-8128R-CY5
Beschreibung:
This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, adevelopmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13198R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13198R
Lokale Artikelnummer::
BOSSBS-13198R
Beschreibung:
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7903R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7903R-A680
Lokale Artikelnummer::
BOSSBS-7903R-A680
Beschreibung:
AKAP associated sperm protein (encoded by the gene ROPN1L) is a sperm protein which interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. The Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helical domain of AKAP3, allowing PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5161R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5161R-CY3
Lokale Artikelnummer::
BOSSBS-5161R-CY3
Beschreibung:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3637R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3637R-A350
Lokale Artikelnummer::
BOSSBS-3637R-A350
Beschreibung:
TSPAN5 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7513R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7513R-FITC
Lokale Artikelnummer::
BOSSBS-7513R-FITC
Beschreibung:
BAI 1 protein is likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. It may function in cell adhesion and signal transduction in the brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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