Soluble+gamma-cyclodextrin+polymer+crosslinked+with+epichlorohydr
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Artikel-Nr:
(PRSI92-628)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-628
Lokale Artikelnummer::
PRSI92-628
Beschreibung:
FNDC5 is a membrane protein comprised by a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a fibronectin type III (FNIII) domain. The ectodomain has been proposed to be cleaved to a soluble peptide hormone named “irisin”. Irisin is secreted from muscle in response to exercise, and may regulate energy metabolism, stem cell differentiation, and neuronal development. The circulating irisin converts white fat into the more thermogenic beige fat, and may mediate some beneficial effects of exercise in humans and the potential for generating weight loss. In mice, expression of Irisin has been shown to regulate obesity and diabetes. A similar function is suggested in human.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-10361R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10361R-A647
Lokale Artikelnummer::
BOSSBS-10361R-A647
Beschreibung:
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10361R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10361R-HRP
Lokale Artikelnummer::
BOSSBS-10361R-HRP
Beschreibung:
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1655R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1655R-HRP
Lokale Artikelnummer::
BOSSBS-1655R-HRP
Beschreibung:
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13248R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13248R-A647
Lokale Artikelnummer::
BOSSBS-13248R-A647
Beschreibung:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G alpha subunits have been identified; these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4760R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4760R
Lokale Artikelnummer::
BOSSBS-4760R
Beschreibung:
Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13248R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13248R-A350
Lokale Artikelnummer::
BOSSBS-13248R-A350
Beschreibung:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G alpha subunits have been identified; these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).
VE:
1 * 100 µl
Artikel-Nr:
(PRSI91-208)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-208
Lokale Artikelnummer::
PRSI91-208
Beschreibung:
Gamma-Glutamylaminecyclotransferase is an enzyme that converts gamma-glutamylamines to free amines and 5-oxoproline which belongs to the gamma-glutamylcyclotransferase family. It shows high activity toward gamma-glutamyl-epsilon-lysine, derived from the breakdown of fibrin and contributes to degradation of proteins cross-linked by transglutaminases. It degrades the cross-link between a lysine and a glutamic acid residue from two proteins that have been cross-linked by transglutaminases. This protein adopts the newly identified cyclotransferase fold, observed in Gamma-Glutamylcyclotransferase, an enzyme with activity toward gamma-glutamyl-alpha-amino acids.
VE:
1 * 50 µG
Lieferant:
BIOLEGEND INC
Beschreibung:
Anti-IFN-gamma Mouse Monoclonal Antibody [clone: NIB42] (Ultra-LEAF™)
Artikel-Nr:
(PRSI33-302)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-302
Lokale Artikelnummer::
PRSI33-302
Beschreibung:
Recognises a protein of 55 kDa, identified as Cluster of Differentiation 14 (also known lipopolysaccharide receptor or LPSR). CD14 is expressed strongly on monocytes and macrophage and weakly on the surface of neutrophils. It is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14, also binding to LPS, acts at physiological concentration as an LPS agonist and has, at higher concentrations, an LPS antagonizing effect in cell activation.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(BSBTPB9124)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9124
Lokale Artikelnummer::
BSBTPB9124
Beschreibung:
Polyclonal antibody for CD143/ACE detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. CD143/ACE information: Molecular Weight: 149715 MW; Subcellular Localization: Angiotensin-converting enzyme, soluble form: Secreted; Tissue Specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
VE:
1 * 100 µG
Artikel-Nr:
(BLEG308611)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
308611
Lokale Artikelnummer::
BLEG308611
Beschreibung:
Anti-CD119 (IFN-gamma R alpha chain) Mouse Monoclonal Antibody [clone: GIR-208] (TotalSeq™-B0219)
VE:
1 * 10 µG
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Artikel-Nr:
(BLEG308607)
Lieferant:
BIOLEGEND INC
Hersteller-Artikelnummer::
308607
Lokale Artikelnummer::
BLEG308607
Beschreibung:
Anti-CD119 (IFN-gamma R alpha chain) Mouse Monoclonal Antibody [clone: GIR-208] (TotalSeq™-A0219)
VE:
1 * 10 µG
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Artikel-Nr:
(ABNOPAB18916)
Lieferant:
Abnova
Hersteller-Artikelnummer::
PAB18916
Lokale Artikelnummer::
ABNOPAB18916
Beschreibung:
Goat anti-monkey IgG recognizes monkey IgG gamma heavy chain. This secondary antibody was purified using antigen affinity chromatography. The antibody is conjugated with Peroxidase.
VE:
1 * 1 mg
Artikel-Nr:
(BSBTPA1581)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PA1581
Lokale Artikelnummer::
BSBTPA1581
Beschreibung:
Rabbit IgG polyclonal antibody for Laminin subunit gamma-1(LAMC1) detection. Tested with WB, IHC-P in Human; Mouse; Rat.
VE:
1 * 0,1 mg
Artikel-Nr:
(PRSI3223)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3223
Lokale Artikelnummer::
PRSI3223
Beschreibung:
SARS Spike Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.
VE:
1 * 100 µG
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