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4,4\'-Dimethoxydiphenylamin
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4,4\'-Dimethoxydiphenylamin
Artikel-Nr:
(BOSSBS-2081R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2081R-CY7
Lokale Artikelnummer::
BOSSBS-2081R-CY7
Beschreibung:
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7779R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7779R-CY7
Lokale Artikelnummer::
BOSSBS-7779R-CY7
Beschreibung:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3123R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3123R-CY3
Lokale Artikelnummer::
BOSSBS-3123R-CY3
Beschreibung:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3158R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3158R-CY3
Lokale Artikelnummer::
BOSSBS-3158R-CY3
Beschreibung:
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8471R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8471R-CY5.5
Lokale Artikelnummer::
BOSSBS-8471R-CY5.5
Beschreibung:
Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin and F-box proteins act as protein-ubiquitin ligases and mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognizes and binds to phosphorylated target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1984R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1984R-CY3
Lokale Artikelnummer::
BOSSBS-1984R-CY3
Beschreibung:
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1826R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1826R-CY5
Lokale Artikelnummer::
BOSSBS-1826R-CY5
Beschreibung:
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8471R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8471R-CY3
Lokale Artikelnummer::
BOSSBS-8471R-CY3
Beschreibung:
Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin and F-box proteins act as protein-ubiquitin ligases and mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognizes and binds to phosphorylated target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8471R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8471R-A750
Lokale Artikelnummer::
BOSSBS-8471R-A750
Beschreibung:
Members of the F-box protein family, such as FBXO33, are characterised by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin and F-box proteins act as protein-ubiquitin ligases and mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognises and binds to phosphorylated target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2503R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2503R-CY5
Lokale Artikelnummer::
BOSSBS-2503R-CY5
Beschreibung:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9301R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9301R-HRP
Lokale Artikelnummer::
BOSSBS-9301R-HRP
Beschreibung:
SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1864R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1864R-A350
Lokale Artikelnummer::
BOSSBS-1864R-A350
Beschreibung:
SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1864R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1864R-CY3
Lokale Artikelnummer::
BOSSBS-1864R-CY3
Beschreibung:
SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4846R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4846R-CY7
Lokale Artikelnummer::
BOSSBS-4846R-CY7
Beschreibung:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6698R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6698R
Lokale Artikelnummer::
BOSSBS-6698R
Beschreibung:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4846R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4846R-CY5.5
Lokale Artikelnummer::
BOSSBS-4846R-CY5.5
Beschreibung:
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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