Tris(2,2,2-trifluoroethyl)+Phosphate
Artikel-Nr:
(USBI040079-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
040079-BIOTIN
Lokale Artikelnummer::
USBI040079-BIOTIN
Beschreibung:
Anti-PIP5KL1 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-12550R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12550R
Lokale Artikelnummer::
BOSSBS-12550R
Beschreibung:
Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13386R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13386R
Lokale Artikelnummer::
BOSSBS-13386R
Beschreibung:
Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2125R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2125R-CY7
Lokale Artikelnummer::
BOSSBS-2125R-CY7
Beschreibung:
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).
VE:
1 * 100 µl
Lieferant:
Merck Millipore (Calbiochem)
Beschreibung:
Creatine phosphate, dipotassium salt is a high-energy phosphate compound for transfer of phosphate groups in the creatine phosphate energy shuttle.
Artikel-Nr:
(USBI039924)
Lieferant:
US Biological
Hersteller-Artikelnummer::
039924
Lokale Artikelnummer::
USBI039924
Beschreibung:
Anti-PGM3 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Artikel-Nr:
(LAMA1960)
Lieferant:
LAMAPLAST
Hersteller-Artikelnummer::
1960
Lokale Artikelnummer::
LAMA1960
Beschreibung:
Adapter AD/TS, HDPE, für Fässer mit TRI-SURE-Deckel
VE:
1 * 1 ST
Artikel-Nr:
(J61196.AP)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J61196.AP
Lokale Artikelnummer::
ALFAJ61196.AP
Beschreibung:
Phosphate-buffered saline (PBS), sterile filtered, 1X, Liquid
VE:
1 * 500 mL
Artikel-Nr:
(USBI042272)
Lieferant:
US Biological
Hersteller-Artikelnummer::
042272
Lokale Artikelnummer::
USBI042272
Beschreibung:
Anti-TRIM51 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
Ruthenium(III)acetylacetonat, Sigma-Aldrich®
Artikel-Nr:
(WATEWAT085101)
Lieferant:
WATERS
Hersteller-Artikelnummer::
WAT085101
Lokale Artikelnummer::
WATEWAT085101
Beschreibung:
Tetrabutylammonium phosphate, PIC A reagent, low UV
VE:
1 * 1 ST
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Lieferant:
Alfa Aesar
Beschreibung:
Potassium phosphate, 0,2M buffer solution, pH 7,4, Liquid
Artikel-Nr:
(BOSSBS-12550R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12550R-A555
Lokale Artikelnummer::
BOSSBS-12550R-A555
Beschreibung:
Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three Alpha chains and three Beta chains, which are weakly homologous, as well as one Gamma chain, one Delta chain and one Gamma chain. F0 consists of three subunits: a, b and c. A mitochondrial F1-ATPase inhibitor protein, ATPIF1 (ATPase inhibitory factor 1), also known as IP, IF1, ATPI or ATPIP (ATPase inhibitor protein), binds to the C-terminal region of a Beta subunit of the F1-ATPase at low pH values and, via interference of the Beta and Gamma subunit interaction, ATPIF1 regulates the activity of the F1F0-ATPase. This reversible ATPIF1 binding to F1F0-ATPase also occurs on the surface of endothelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13345R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13345R-CY5
Lokale Artikelnummer::
BOSSBS-13345R-CY5
Beschreibung:
The GGA family of proteins (Golgi-localized, g-Adaptin ear-containing, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin. Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multi-domain proteins that bind mannose 6-phosphate receptors (MPRs). GGAs have modular structures with an N-terminal VHS (VPS27, Hrs and STAM) domain followed by a GAT (GGA and Tom1) domain, a connecting hinge segment and a C-terminal GAE (g-Adaptin ear) domain. The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences. The human GGA3 gene maps to chromosome 17 and encodes a 723 amino acid protein that shares 46% sequence identity with GGA1 and 38% with GGA2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13264R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13264R-A680
Lokale Artikelnummer::
BOSSBS-13264R-A680
Beschreibung:
There are two forms of glutamic acid decarboxylases (GADs) that exist in brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 transiently activates to assist in GABA production. As a member of the group II decarboxylase family, GADL1 (Glutamate decarboxylase-like protein 1) is a 521 amino acid protein that utilizes pyridoxal phosphate as a cofactor for its carboxylase activity. There are two isoforms of GADL1 that exist as a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1712R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1712R-CY7
Lokale Artikelnummer::
BOSSBS-1712R-CY7
Beschreibung:
Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes.
In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection.
VE:
1 * 100 µl
Preis auf Anfrage
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