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2-(4-Methoxyphenyl)isonicotinonitril


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Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-2769R-A750
Lokale Artikelnummer:: BOSSBS-2769R-A750
Beschreibung:   Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
VE:  1 * 100 µl
Lieferant:  COMBI-BLOCKS
Hersteller-Artikelnummer:: BB-8578-250M
Lokale Artikelnummer:: COBBBB-8578-250M
Beschreibung:   1-(2-Tetrahydropyranyl)-1H-pyrazol-4-boronsäureneopentylglycolester
VE:  1 * 250 mg
Market Source Item This is a MarketSource item. Additional charges may apply

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-2769R-A680
Lokale Artikelnummer:: BOSSBS-2769R-A680
Beschreibung:   Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. GRB14 is a potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
VE:  1 * 100 µl
Lieferant:  Thermo Scientific
Beschreibung:   Desoxycholsäure 98.5%
Lieferant:  Sigma-Aldrich
Beschreibung:   5,5-Dimethyl-2,4-imidazolidindion, Sigma-Aldrich®
Lieferant:  Sigma-Aldrich
Beschreibung:   Empigen BB is a zwitterionic detergent compatible with anionic, non-ionic, cationic and other amphoteric surfactants.
Lieferant:  Sigma-Aldrich
Beschreibung:   Menadion (2-Methyl-1,4-naphthochinon, Vitamin K3), Sigma-Aldrich®
Lieferant:  Honeywell Chemicals
Beschreibung:   ACS GENERAL USE SOLVENTS
Artikel-Nr: (MOLEM83988571)

Lieferant:  Molekula
Hersteller-Artikelnummer:: M83988571
Lokale Artikelnummer:: MOLEM83988571
Beschreibung:   trans-2,3-Dibrom-2-buten-1,4-diol
VE:  1 * 100 g
Market Source Item This is a MarketSource item. Additional charges may apply
Lieferant:  Cayman Chemical
Beschreibung:   Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Taurodeoxycholic acid stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally. Serum levels of taurodeoxycholic acid increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.
Lieferant:  Merck
Beschreibung:   Benzamidin Hydrochlorid Hydrat, Sigma-Aldrich®
Lieferant:  Spectrum Chemical
Beschreibung:   Riboflavin, USP is also referred to as vitamin B2 and used as a dietary supplement.
Lieferant:  COMBI-BLOCKS
Beschreibung:   1,4-Dioxaspiro[4.5]decan-8-on
Lieferant:  Sigma-Aldrich
Hersteller-Artikelnummer:: P3405-100G
Lokale Artikelnummer:: SIALP3405-100G
Beschreibung:   POPSO (β,β'-Dihydroxypiperazin-1,4-dipropansulfonsäure) Dihydrat, Sigma-Aldrich®
VE:  1 * 100 g
Lieferant:  Sigma-Aldrich
Beschreibung:   Riboflavin-5'-phosphat Natriumsalz Dihydrat, Sigma-Aldrich®
Lieferant:  FLUOROCHEM
Beschreibung:   1,4-Bis(1,1,2,2-tetrafluorethoxy)benzol
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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