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beta-Methyl-gamma-octanolactone+(mixture+of+isomers)
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beta-Methyl-gamma-octanolactone+(mixture+of+isomers)
Artikel-Nr:
(BOSSBS-20595R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-20595R-A750
Lokale Artikelnummer::
BOSSBS-20595R-A750
Beschreibung:
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidised low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalised and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL.
VE:
1 * 100 µl
Artikel-Nr:
(E169-100G)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRCE169-100G
Beschreibung:
Biological buffers are useful for cell culture <i>in vitro</i>, enzyme assays, and some electrophoretic applications at physiological pH.
VE:
1 * 100 g
Artikel-Nr:
(BOSSBS-12859R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12859R-A680
Lokale Artikelnummer::
BOSSBS-12859R-A680
Beschreibung:
Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into a, b, and g families, and the b- and g-crystallins also comprise a superfamily. Crystallins usually contain seven distinctive protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. b-crystallins constitute the major lens structural proteins. They associate into dimers, tetramers, and higher order aggregates. The b-crystallin subfamily is composed of several gene products, including bA1-, bA2-, bA3-, bA4-, bB1-, bB2- and bB3-crystallin. The bA1- and bA3-crystallin proteins are encoded by a single mRNA. They differ by only 17 amino acids, and bA1-crystallin is generated by use of an alternate translation initiation site. The genes for bA4-, bB1-, bB2- and bB3-crystallin are clustered on human chromosome 22q11, while the genes for bA3/A1- and bA2-crystallin map to human chromosomes 17q11 and 2q34, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6457R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6457R-HRP
Lokale Artikelnummer::
BOSSBS-6457R-HRP
Beschreibung:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7931R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7931R-HRP
Lokale Artikelnummer::
BOSSBS-7931R-HRP
Beschreibung:
Protein phosphatase 2A (PP2A) is the most abundant phosphatase specific for serine and threonine phosphorylation in mammalian cells. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit alpha (PPP2R1A) serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory beta subunit.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3807R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3807R-A750
Lokale Artikelnummer::
BOSSBS-3807R-A750
Beschreibung:
Phospholipase A2 activator protein (PLAP), activates PLA2 (phospholipase A2 enzyme) and is an important mediator of eicosanoid generation. Also known as a pro-inflammatory agent, PLAP has been found in inflamed tissues and synovial fluid from patients with rheumatoid arthritis. As such, it is believed to play an important role in the regulation of inflammatory diseases. The formation of PLAP can be stimulated by IL-1 beta and TNF-alpha.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3724R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3724R-A647
Lokale Artikelnummer::
BOSSBS-3724R-A647
Beschreibung:
This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10150R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-FITC
Lokale Artikelnummer::
BOSSBS-10150R-FITC
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2518R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2518R-FITC
Lokale Artikelnummer::
BOSSBS-2518R-FITC
Beschreibung:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2518R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2518R-A647
Lokale Artikelnummer::
BOSSBS-2518R-A647
Beschreibung:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11181R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11181R-A350
Lokale Artikelnummer::
BOSSBS-11181R-A350
Beschreibung:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2518R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2518R-A555
Lokale Artikelnummer::
BOSSBS-2518R-A555
Beschreibung:
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
VE:
1 * 100 µl
Lieferant:
HICHROM GAS CHROMATOGRAPHY
Beschreibung:
Nützlich für die Analyse chiraler Verbindungen in Duftstoffen, Pestiziden und Pharmazeutika, bei denen die Bestimmung des Enantiomerenverhältnisses in einer Probe erforderlich ist.
Artikel-Nr:
(BOSSBS-3299R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3299R-CY5
Lokale Artikelnummer::
BOSSBS-3299R-CY5
Beschreibung:
E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3299R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3299R-A750
Lokale Artikelnummer::
BOSSBS-3299R-A750
Beschreibung:
E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5986R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5986R-CY5.5
Lokale Artikelnummer::
BOSSBS-5986R-CY5.5
Beschreibung:
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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