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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
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2-Bromo-5-fluorobenzo[b]furan-3(2H)-one
Artikel-Nr:
(BOSSBS-11715R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11715R-CY7
Lokale Artikelnummer::
BOSSBS-11715R-CY7
Beschreibung:
CLN8, a 286 amino acid transmembrane protein, localizes mainly to the endoplasmic reticulum, but also partially to the ER-Golgi intermediate compartment (ERGIC). Mutations in the CLN8 gene cause neuronal ceroid lipofuscinosis 8 and progressive epilepsy with mental retardation (EPMR). Both disorders are forms of neuronal ceroid-lipofuscinose (NCL), a group of progressive neurodegenerative diseases found in children, characterized by failure of psychomotor development, impaired vision, seizures and premature death. The CLN8 protein is one of eight proteins in the CLN family, including CLN1-CLN7, which are associated with NCL.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5825R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5825R-CY5
Lokale Artikelnummer::
BOSSBS-5825R-CY5
Beschreibung:
The PCDHA12 gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five, which demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins which may play a role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
This MAb is specific to kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of kappa to lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Lieferant:
Biotium
Beschreibung:
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
Artikel-Nr:
(BOSSBS-2679R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2679R-CY3
Lokale Artikelnummer::
BOSSBS-2679R-CY3
Beschreibung:
Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1394R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1394R-CY7
Lokale Artikelnummer::
BOSSBS-1394R-CY7
Beschreibung:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1394R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1394R
Lokale Artikelnummer::
BOSSBS-1394R
Beschreibung:
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7789R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7789R-A680
Lokale Artikelnummer::
BOSSBS-7789R-A680
Beschreibung:
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0437R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0437R-A750
Lokale Artikelnummer::
BOSSBS-0437R-A750
Beschreibung:
Streptavidin is biotin-binding protein that was originally isolated from Streptomyces avidinii. In contrast to avidin, streptavidin has no carbohydrate and has a mildly acidic pI of 5. Streptavidin products use a recombinant form of streptavidin having a mass of 53,000 daltons and a near-neutral pI. Streptavidin is a tetrameric protein, with each subunit binding one molecule of biotin with affinity similar to that of avidin. Guanidinium chloride will dissociate avidin and streptavidin into subunits, but streptavidin is more resistant to dissociation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8577R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8577R-A680
Lokale Artikelnummer::
BOSSBS-8577R-A680
Beschreibung:
GPKOW is a potential RNA-binding protein consisting of one central G patch domain and two C-terminal KOW domains. T54 is a 476 amino acid protein belonging to the MOS2 family. It is a mammalian homolog of the Arabidopsis thaliana MOS2 (modifier of SNC1, 2) nuclear protein that is required for innate immunity. Similar to A. thaliana MOS2, T54 localises to the nucleus and contains G patch and KOW domains, suggesting that T54 may play a similar role in mammalian innate immunity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8435R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8435R-A750
Lokale Artikelnummer::
BOSSBS-8435R-A750
Beschreibung:
BXDC1 is a 306 amino acid protein encoded by the human gene BXDC1. BXDC1 is a nuclear protein that contains one Brix domain. Brix domain containing proteins represent a family of proteins involved in the biogenesis of large ribosomal subunits. The Brix domain is a region with homology to the yeast protein Pitx1 (Ribosome biogenesis protein BRX1). Pitx1 is part of a complex that includes RPF1, RPF2 and SSF1 or SSF2. This complex is required for the biogenesis of the 60S ribosomal subunit.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6283R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6283R-A680
Lokale Artikelnummer::
BOSSBS-6283R-A680
Beschreibung:
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BSENR-1701-100)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
R-1701-100
Lokale Artikelnummer::
BSENR-1701-100
Beschreibung:
Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a metabolic enzyme responsible for catalyzing one step in the glycolytic pathway, the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate. GAPDH may have other roles in the activation of transcription and in the regulation of apoptosis as well as Alzheimer's disease and Huntington's disease. The immunogen used to raise this particular antibody was extensively purified pig GAPDH. This antibody can be used as a loading control for western blotting experiments, allowing comparison between the level of this protein and others in a cell or tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5713R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5713R-HRP
Lokale Artikelnummer::
BOSSBS-5713R-HRP
Beschreibung:
HOXA5 upregulates both p53 promoter-reporter constructs and endogenous p53 synthesis, leading to apoptosis. HOXA5 is detectable in approximately one-third of primary tumors. Lack of HOXA5 expression strongly correlates with methylation of its promoter region, suggesting a causal role for methylation in the silencing of HOXA5 gene expression. HOXA5 expression is an important step in tumorigenesis and loss of expression of p53 in human breast cancer may be primarily due to lack of expression of HOXA5.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5145R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5145R-FITC
Lokale Artikelnummer::
BOSSBS-5145R-FITC
Beschreibung:
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13263R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13263R-HRP
Lokale Artikelnummer::
BOSSBS-13263R-HRP
Beschreibung:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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