Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-10560R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-10560R-A680

Lokale Artikelnummer:: BOSSBS-10560R-A680

Beschreibung: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8367R-CY5.5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8367R-CY5.5

Lokale Artikelnummer:: BOSSBS-8367R-CY5.5

Beschreibung: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9132R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9132R-CY7

Lokale Artikelnummer:: BOSSBS-9132R-CY7

Beschreibung: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9132R-CY3)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9132R-CY3

Lokale Artikelnummer:: BOSSBS-9132R-CY3

Beschreibung: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8391R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8391R-HRP

Lokale Artikelnummer:: BOSSBS-8391R-HRP

Beschreibung: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8391R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8391R-A350

Lokale Artikelnummer:: BOSSBS-8391R-A350

Beschreibung: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8391R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8391R-A647

Lokale Artikelnummer:: BOSSBS-8391R-A647

Beschreibung: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9340R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9340R-A488

Lokale Artikelnummer:: BOSSBS-9340R-A488

Beschreibung: MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9340R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9340R-FITC

Lokale Artikelnummer:: BOSSBS-9340R-FITC

Beschreibung: MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2125R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-2125R-A750

Lokale Artikelnummer:: BOSSBS-2125R-A750

Beschreibung: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalised to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalised proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-2125R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-2125R-HRP

Lokale Artikelnummer:: BOSSBS-2125R-HRP

Beschreibung: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4090R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4090R-HRP

Lokale Artikelnummer:: BOSSBS-4090R-HRP

Beschreibung: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4090R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4090R-A647

Lokale Artikelnummer:: BOSSBS-4090R-A647

Beschreibung: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-4090R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-4090R-A555

Lokale Artikelnummer:: BOSSBS-4090R-A555

Beschreibung: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-1686R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-1686R-A647

Lokale Artikelnummer:: BOSSBS-1686R-A647

Beschreibung: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-12482R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-12482R-A488

Lokale Artikelnummer:: BOSSBS-12482R-A488

Beschreibung: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].

VE: 1 * 100 µl

Sale