Sie suchten nach: TONBO BIOSCIENCE

Artikel-Nr: (40-4732-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 40-4732-U100

Lokale Artikelnummer:: TNBO40-4732-U100

Beschreibung: The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.

Artikel-Nr: (67-4724-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 67-4724-U100

Lokale Artikelnummer:: TNBO67-4724-U100

Beschreibung: The C1.18.4 immunoglobulin is useful as an isotype-matched control. The C.1.18.4 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2a antibodies.

VE: 1 * 100 µG

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Artikel-Nr: (72-8062-M001)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 72-8062-M001

Lokale Artikelnummer:: TNBO72-8062-M001

Beschreibung: Goat anti-Mouse IgG (H&L) - Affinity Pure, HRP Conjugate, min x w/bovine, goat, human, rabbit or rat IgG

VE: 1 * 1 mg

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Artikel-Nr: (30-8075-M001)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 30-8075-M001

Lokale Artikelnummer:: TNBO30-8075-M001

Beschreibung: Rabbit anti-Human IgM (mu chain) - Affinity Pure, Biotin Conjugate

VE: 1 * 1 mg

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Artikel-Nr: (30-8067-M002)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 30-8067-M002

Lokale Artikelnummer:: TNBO30-8067-M002

Beschreibung: Goat anti-Rabbit IgG (H&L) - Affinity Pure, Biotin Conjugate

VE: 1 * 2 mg

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Artikel-Nr: (35-8057-U500)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 35-8057-U500

Lokale Artikelnummer:: TNBO35-8057-U500

Beschreibung: Goat anti-Mouse IgG (H&L) - F(ab')2 fragment, FITC Conjugate, min x w/bovine, goat, human, rabbit, or rat IgG

VE: 1 * 0,5 mg

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Artikel-Nr: (70-8064-M002)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 70-8064-M002

Lokale Artikelnummer:: TNBO70-8064-M002

Beschreibung: Goat anti-Mouse IgM (H&L) - Affinity Pure

VE: 1 * 2 mg

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Artikel-Nr: (70-0048-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 70-0048-U100

Lokale Artikelnummer:: TNBO70-0048-U100

Beschreibung: The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

VE: 1 * 100 µG

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Lieferant: Tonbo Biosciences

Beschreibung: The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.

Lieferant: Tonbo Biosciences

Beschreibung: The BM8.1 antibody is specific for mouse F4/80 antigen, a 125 kDa transmembrane protein widely expressed by members of the mononuclear phagocyte system and considered to be a key marker for mature macrophage cells. F4/80 is differentially expressed during myeloid cell development, and may be regulated by certain cytokines within the tissue microenvironment. Other cell types shown to express this antigen include Langerhans cells, Kupffer cells and dendritic cell subsets. BM8.1 is widely used together with antibodies to CD115 (c-fms), CD11b and CD11c to identify myeloid / macrophage cells by flow cytometry.

Artikel-Nr: (35-4732-U100)

Lieferant: Tonbo Biosciences

Hersteller-Artikelnummer:: 35-4732-U100

Lokale Artikelnummer:: TNBO35-4732-U100

Beschreibung: The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.

VE: 1 * 100 µG

Sale

Lieferant: Tonbo Biosciences

Beschreibung: The GARP5 antibody reacts with human GARP, also known as LRRC32 or Garpin, an 80 kDa transmembrane protein which acts as a receptor for the latent form of TGF-beta 1 (pro-TGF-beta), preventing its secretion. Specifically, GARP is reported to associate with the pro-domain of TGF-beta 1, known as latency-associated peptide (LAP), which must be cleaved to release the biologically active cytokine. The putative role of GARP in sequestering the TGF-beta is important for regulating its activity, as TGF-beta signaling is involved in development and function of Th17, Treg and many other immune cell types. GARP expression has been shown on platelets and at high levels on Foxp3+ Treg cells, where it is proposed to be a phenotypic identifier for activated human Treg cells.

Lieferant: Tonbo Biosciences

Beschreibung: The 30-H12 antibody reacts with mouse CD90.2 (Thy1.2). CD90.2 is a strain-specific allelic form of the GPI-linked membrane associated protein CD90 and is involved in adhesion and signal transduction. CD90.2 is expressed on thymocytes, mature T cells and neurons in mouse strains that express the CD90.2 allele (BALB/c, CBA, C3H, C57BL/6, SJL and others). 30-H12 does not react with the CD90.1 allele expressed in mouse strains such as PL and AKR.

Lieferant: Tonbo Biosciences

Beschreibung: The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.

Lieferant: Tonbo Biosciences

Beschreibung: The O323 antibody reacts with human CD27 (TNFRSF7), a cell surface homodimer of 55 kDa subunits, which provides co-stimulatory signaling in support of the T cell (TCR) and B cell (BCR) receptors. By comparison with CD28, whose TCR co-stimulatory signal can trigger cell proliferation, CD27 signaling appears to promote cell survival and differentiation to effector / memory stages. Also in contrast with CD28, the CD27 receptor may be shed following interaction with its ligand CD70, which is typically expressed on activated dendritic cells, T cells and B cells. With respect to B cells, CD27 is considered to be a phenotypic marker for memory B cells. CD27 has been included within a group of phenotypic markers for identifying human B regulatory cells (Bregs), a cell type proposed to regulate CD4+ T cell proliferation and Foxp3 / CTLA-4 expression in Treg cells.