Drucken
Artikel-Nr:
(BOSSBS-10307R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10307R-A555
Lokale Artikelnummer::
BOSSBS-10307R-A555
Beschreibung:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7q32, 3q28, 4q32, Xp22.3, Xp11.23-p11.22, 1p36 and 16p13, respectively. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3766R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3766R-A488
Lokale Artikelnummer::
BOSSBS-3766R-A488
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
VE:
1 * 100 µl
Lieferant:
LEICA HISTOLOGY
Beschreibung:
ActivFlo Routine I Kassetten sind Infiltrationskassetten mit patentiertem seitlichem Entlüftungssystem für maximalen Flüssigkeitsaustausch. Der erhöhte Flüssigkeitsaustausch verringert die Zahl nicht fixierter oder zu schwach infiltrierter Präparate und beschleunigt die Fixierung und Infiltration von Gewebeproben. Diese einteiligen Kassetten besitzen leicht abnehmbare, weil ‘brechbare’ Deckel. Die Kassetten haben ein im Winkel von 45° abgeschrägtes Beschriftungsfeld und wurden für optimale Arbeitsabläufe mit dem Leica IP C Kassettendrucker konzipiert. Sie haben eine Druckfehlerquote von unter einem Prozent.
Artikel-Nr:
(BOSSBS-11952R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11952R-A488
Lokale Artikelnummer::
BOSSBS-11952R-A488
Beschreibung:
The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(USBI030877-HRP)
Lieferant:
US Biological
Hersteller-Artikelnummer::
030877-HRP
Lokale Artikelnummer::
USBI030877-HRP
Beschreibung:
Anti-CLIC5 Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 16CT34.4.8]
VE:
1 * 200 µl
Artikel-Nr:
(BOSSBS-6981R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6981R-A647
Lokale Artikelnummer::
BOSSBS-6981R-A647
Beschreibung:
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
VE:
1 * 100 µl
Artikel-Nr:
(ACRO197630010)
Lieferant:
Thermo Scientific
Hersteller-Artikelnummer::
197630010
Lokale Artikelnummer::
ACRO197630010
Beschreibung:
Ammoniumhexachloroosmat(IV) 99.99% (bezogen auf die Metalle der seltenen Erden)
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-12124R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12124R-A750
Lokale Artikelnummer::
BOSSBS-12124R-A750
Beschreibung:
The GAT1 gene family includes sodium- and chloride-dependent plasma membrane transporters for neurotransmitters, metabolites and osmolites, which couple substrate flux to transmembrane electrochemical gradients. PROT (Sodium-dependent proline transporter), also known as Solute carrier family 6 member 7, is a 636 amino acid multi-pass membrane protein that is a GAT1 family member specifically expressed in regions of the brain. PROT terminates the action of proline by its high affinity sodium/chloride-dependent reuptake into pre-synaptic terminals. Enriched in glutamatergic synaptic terminals, it is likely that PROT plays an important role in excitatory events of neurotransmission. PROT-mediated proline uptake is inhibited by compounds such as benztropine, LP-403812 and Des-Tyr-Leu-enkephalin (GGFL). These inhibitors of proline uptake may lead to the development of therapeutic agents for certain neurologic disorders.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4112R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4112R-A647
Lokale Artikelnummer::
BOSSBS-4112R-A647
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4112R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4112R-FITC
Lokale Artikelnummer::
BOSSBS-4112R-FITC
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4112R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4112R-A488
Lokale Artikelnummer::
BOSSBS-4112R-A488
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3766R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3766R-A647
Lokale Artikelnummer::
BOSSBS-3766R-A647
Beschreibung:
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11952R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11952R-CY3
Lokale Artikelnummer::
BOSSBS-11952R-CY3
Beschreibung:
The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11952R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11952R
Lokale Artikelnummer::
BOSSBS-11952R
Beschreibung:
The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI1402-14)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
1402-14
Lokale Artikelnummer::
PRSI1402-14
Beschreibung:
Lungengewebelysat (14 Tage alt) wurde durch Homogenisierung in modifiziertem RIPA-Puffer (150 mM Natriumchlorid, 50 mM Tris-HCl, pH 7,4, 1 mM Ethylendiamintetraessigsäure, 1 mM Phenylmethylsulfonylfluorid, 1% Triton X-100, 1% Natriumdesoxycholsäure, 0,1% Natriumdodecylsulfat, 5 μg/ml Aprotinin, 5 μg/ml Leupeptin) hergestellt.
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI1415-7)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
1415-7
Lokale Artikelnummer::
PRSI1415-7
Beschreibung:
Magengewebelysat (7 Tage alt) wurde durch Homogenisierung in modifiziertem RIPA-Puffer (150 mM Natriumchlorid, 50 mM Tris-HCl, pH 7,4, 1 mM Ethylendiamintetraessigsäure, 1 mM Phenylmethylsulfonylfluorid, 1% Triton X-100, 1% Natriumdesoxycholsäure, 0,1% Natriumdodecylsulfat, 5 μg/ml Aprotinin, 5 μg/ml Leupeptin) hergestellt.
VE:
1 * 0,1 mg
New Product
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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