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2-Azaspiro[3.3]heptane-6-carboxylic+acid+trifluoroacetate
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2-Azaspiro[3.3]heptane-6-carboxylic+acid+trifluoroacetate
Artikel-Nr:
(BOSSBS-11386R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11386R-A555
Lokale Artikelnummer::
BOSSBS-11386R-A555
Beschreibung:
AADACL3 is a 350 amino acid protein that belongs to the 'GDXG' lipolytic enzyme family and participates in hydrolase activity. Existing as two alternatively spliced isoforms, AADACL3 is encoded by a gene that maps to human chromosome 1p36.21. Chromosome 1, the largest human chromosome, makes up 8% of the human genome and contains about 260 million base pairs, which encode 3,000 genes. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9264R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9264R-CY5.5
Lokale Artikelnummer::
BOSSBS-9264R-CY5.5
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF215 (ring finger protein 215), is a 377 amino acid multi-pass membrane protein containing one RING-type zinc finger. The gene encoding RNF215 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11642R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11642R-CY3
Lokale Artikelnummer::
BOSSBS-11642R-CY3
Beschreibung:
CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11642R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11642R-CY7
Lokale Artikelnummer::
BOSSBS-11642R-CY7
Beschreibung:
CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.
VE:
1 * 100 µl
Lieferant:
FLUOROCHEM
Beschreibung:
4-Amino-2,3,5,6-tetrafluorbenzoesäure
Artikel-Nr:
(BOSSBS-12358R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12358R-CY7
Lokale Artikelnummer::
BOSSBS-12358R-CY7
Beschreibung:
YKL-39 is a 390 amino acid cartilage protein that belongs to the chitinase family of chitin-fragmenting hydrolases. Highly expressed in chondrocytes (cartilage cells) and synoviocytes (fibroblastic cells that line joint cavities), YKL-39 binds glycan structures with high affinity. Although related to bacterial chitinases, YKL-39 lacks the characteristic glutamate active site and, thus, does not have enzymatic chitinase activity. Patients affected with rheumatoid arthritis (RA) have autoimmunity against YKL-39, suggesting that YKL-39 is involved in osteoarthritic and/or rheumatoid joint disease. Additionally, YKL-39 is upregulated in early degenerative cartilage diseases (such as RA) and may be a marker of chondrocyte activation in these autoimmune conditions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6805R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6805R-CY5.5
Lokale Artikelnummer::
BOSSBS-6805R-CY5.5
Beschreibung:
CLUAP1 (Clusterin associated protein 1) is a 413 amino acid nuclear protein that exists as two alternatively spliced isoforms that interact with Clusterin. CLUAP1 is suggested to play a role in apoptosis and cell proliferation, and is expressed in testis, thrachea and thyroid, with low levels found in adrenal gland and spinal cord. The gene encoding CLUAP1 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13299R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13299R-A750
Lokale Artikelnummer::
BOSSBS-13299R-A750
Beschreibung:
NIPSNAP2 is a 286 amino acid protein that is abundantly expressed in heart and skeletal muscle. Belonging to the NIPSNAP family, NIPSNAP2 may be involved in vesicular transport. NIPSNAP2 contains a signal peptide, a transmembrane domain and two tyrosine phosphorylation sites. NIPSNAP2 is encoded by a gene mapping to human chromosome 7p11.2. Chromosomal region 7p12 is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor. Human chromosome 7 houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6926R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6926R-CY5.5
Lokale Artikelnummer::
BOSSBS-6926R-CY5.5
Beschreibung:
CCDC125, also known as KENAE, is a 511 amino acid protein expressed as two isoforms produced by alternative splicing and encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7015R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7015R
Lokale Artikelnummer::
BOSSBS-7015R
Beschreibung:
STK31 (Serine/threonine protein kinase 31) is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11444R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11444R-A750
Lokale Artikelnummer::
BOSSBS-11444R-A750
Beschreibung:
Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responsible for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8226R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8226R-CY3
Lokale Artikelnummer::
BOSSBS-8226R-CY3
Beschreibung:
FAM161B is a 647 amino acid protein that belongs to the FAM161 family. The gene that encodes FAM161B consists of approximately 16,413 bases and maps to human chromosome 14q24.3. Housing over 700 genes, chromosome 14 comprises nearly 3.5% of the human genome. Chromosome 14 encodes the Presenilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer’s disease. The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. An inversion of the long arm of chromosome 14 is thought to be involved in T-cell chronic lymphocytic leukemia (CLL), a cancer that affects T lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11229R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11229R-CY5
Lokale Artikelnummer::
BOSSBS-11229R-CY5
Beschreibung:
OTUB1 is a 271 amino acid protein that contains one OTU (ovarian tumor) domain and belongs to the OTU family of predicted cysteine proteases. Expressed as two isoforms (one of which is present throughout the body and the other of which is present only in lymphoid tissues), OTUB1 functions as a hydrolase that can remove ubiquitin residues from target proteins, thereby preventing protein degradation and playing an important role in protein turnover. OTUB1 interacts with GRAIL and, via this interaction, plays a role in the regulation and the induction of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to their cognate antigens. Due to its interaction with GRAIL, OTUB1 is an important regulator of immune responses in secondary lymphoid organs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11824R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11824R-CY5
Lokale Artikelnummer::
BOSSBS-11824R-CY5
Beschreibung:
The DCDC2 gene encodes the DCDC2 protein (Doublecortin-containing protein 2, RU2, RU2S) which contains two Doublecortin peptide domains similar to those in the Doublecortin gene. DCDC2 is transcribed as a “normal†gene, which results in a sense transcript (RU2S), but when it is transcribed in the opposite direction, a shorter antisense transcript (RU2AS), which is found in tumors, results. The DCDC2 protein demonstrates ubiquitous expression, whereas RU2AS expression is restricted to normal kidney, bladder, liver and testis, and to tumors of various histologic origins. The deduced DCDC2 protein contains 476 amino acids, while the RU2AS protein contains 84 residues. There is a significant association between dyslexia and several SNPs within the DCDC2 gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13375R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13375R-A680
Lokale Artikelnummer::
BOSSBS-13375R-A680
Beschreibung:
The GLIPR1 family consists of three core members, designated GLIPR1, GLIPR1L1 (GLIPR1-like protein 1) and GLIPR1L2, which form a distinct subgroup within the cysteine-rich secretory protein (CRISP), antigen 5 and pathogenesis-related 1 (CAP) superfamily. Each member of the CAP superfamily has a conserved N-terminal CAP domain and a distinct C-terminal extension. CAP superfamily proteins are hypothesized to have roles in immunity, cell adhesion, carcinogenesis and male fertility. GLIPR1L1 is a 242 amino acid secreted protein. Highly expressed in testis, GLIPR1L1 exists as two isoforms produced by alternative splicing events. GLIPR1L1 is encoded by a gene that maps to human chromosome 12q21.1 and mouse chromosome 10 D2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13299R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13299R-CY5
Lokale Artikelnummer::
BOSSBS-13299R-CY5
Beschreibung:
NIPSNAP2 is a 286 amino acid protein that is abundantly expressed in heart and skeletal muscle. Belonging to the NIPSNAP family, NIPSNAP2 may be involved in vesicular transport. NIPSNAP2 contains a signal peptide, a transmembrane domain and two tyrosine phosphorylation sites. NIPSNAP2 is encoded by a gene mapping to human chromosome 7p11.2. Chromosomal region 7p12 is amplified in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumor. Human chromosome 7 houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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