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Ethyl+4-bromo-3-fluorobenzoate
Lieferant:
Alfa Aesar
Beschreibung:
Maprotilin Hydrochlorid 99%
Artikel-Nr:
(BOSSBS-9435R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9435R-A488
Lokale Artikelnummer::
BOSSBS-9435R-A488
Beschreibung:
Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9435R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9435R-A350
Lokale Artikelnummer::
BOSSBS-9435R-A350
Beschreibung:
Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
4'-Brom-3-chlorpropiophenon ≥94%
Artikel-Nr:
(BOSSBS-5048R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5048R-A647
Lokale Artikelnummer::
BOSSBS-5048R-A647
Beschreibung:
Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11058R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11058R-A488
Lokale Artikelnummer::
BOSSBS-11058R-A488
Beschreibung:
May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0117R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0117R-CY5.5
Lokale Artikelnummer::
BOSSBS-0117R-CY5.5
Beschreibung:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2937R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2937R-A555
Lokale Artikelnummer::
BOSSBS-2937R-A555
Beschreibung:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2937R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2937R-A488
Lokale Artikelnummer::
BOSSBS-2937R-A488
Beschreibung:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(USBIH9117-83V)
Lieferant:
US Biological
Hersteller-Artikelnummer::
H9117-83V
Lokale Artikelnummer::
USBIH9117-83V
Beschreibung:
Anti-Hydroxysteroid Dehydrogenase, 17-beta 10 Rabbit Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-11044R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11044R-CY3
Lokale Artikelnummer::
BOSSBS-11044R-CY3
Beschreibung:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11044R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11044R-A750
Lokale Artikelnummer::
BOSSBS-11044R-A750
Beschreibung:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalisation motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilising the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
VE:
1 * 100 µl
Artikel-Nr:
(ROCK600-401-253)
Lieferant:
Rockland Immunochemicals
Hersteller-Artikelnummer::
600-401-253
Lokale Artikelnummer::
ROCK600-401-253
Beschreibung:
Affinity purified anti-beta amyloid detects beta amyloid in ELISA, IHC and IF. A 40-50 kD band consistent with a higher MW precursor is detected in western blot using whole tissue extracts from mouse brain.
VE:
1 * 100 µG
Lieferant:
Tonbo Biosciences
Beschreibung:
The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
2-Aminoethyl 3-O-(α-D-galactopyranosyl)-β-D-galactopyranoside ≥98%
Artikel-Nr:
(ABCAAB277785-100)
Lieferant:
Abcam
Hersteller-Artikelnummer::
AB277785-100
Lokale Artikelnummer::
ABCAAB277785-100
Beschreibung:
Anti-beta Catenin (phospho S552) Rabbit Recombinant Multiclonal Antibody [clone: 1HCLC]
VE:
1 * 100 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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