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Artikel-Nr:
(PRSI92-447)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-447
Lokale Artikelnummer::
PRSI92-447
Beschreibung:
Dtk, also called Tyro3, belongs to the TAM receptor family of receptor protein tyrosine kinases (RPTKs) composed of three receptors Tyro3, Axl, and Mer. These receptors share a characteristic molecular structure of two immunoglobulin-like and two fibronectin type III repeats and have been best characterised for their roles in immune regulation, fertility, thrombosis and phagocytosis. Gas6 and protein S have been identified as ligands for these receptors. Gas6 binding induces tyrosine phosphorylation and downstream signalling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. Tyro3 and Axl play important regulatory roles in a variety of tissues, including the central nervous, reproductive, immune, and vascular systems. Tyro3 is widely expressed during embryonic development and preferentially expressed during neurogenesis in the central nervous system.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death.
Artikel-Nr:
(PRSI96-353)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-353
Lokale Artikelnummer::
PRSI96-353
Beschreibung:
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-071)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-071
Lokale Artikelnummer::
PRSI90-071
Beschreibung:
The Notch ligand delta-like protein 1 (DLL1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 22 (IL-22), also called IL-TIF, is an IL-10 family member that is produced by activated dendritic cells and T lymphocytes. IL-22 signals via a heteroduplex receptor consisting of IL-22R and IL-10RB chains. IL-22 is a potent mediator of cellular inflammatory responses and wound healing.
Artikel-Nr:
(PRSI91-054)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-054
Lokale Artikelnummer::
PRSI91-054
Beschreibung:
The Galectin family of proteins (with specificity for Nacetyllactosamine containing glycoproteins) consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). At least 14 mammalian galectins family members that share structural similarities in their carbohydrate recognition domains (CRD) have been identified to date. Unlike the selectin family of proteins, the carbohydrate binding specificity of galectins is calcium-independent. A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins (1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins (Galectin3) containing one CRD linked to a nonlectin domain, and the tandem repeat Galectins (4, 6, 8, 9, 12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell surface glycoproteins.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-741)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-741
Lokale Artikelnummer::
PRSI96-741
Beschreibung:
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG). TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11. TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5395P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5395P
Lokale Artikelnummer::
PRSI5395P
Beschreibung:
Prosapip1 peptide is used for blocking the activity of Prosapip1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-556)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-556
Lokale Artikelnummer::
PRSI91-556
Beschreibung:
Zymogen Granule Membrane Protein 16 (ZG16) belongs to the jacalin lectin family. ZG16 is highly expressed in liver and is detected at lower levels in colon, ileum and jejunum. ZG16 may play a role in protein trafficking. In addition, ZG16 may act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Fibroblast growth factor 22 (FGF-22) is a mediator of synaptogenesis in the adult nervous system and functions to regulate synapse formation and maturation.
Artikel-Nr:
(PRSI91-419)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-419
Lokale Artikelnummer::
PRSI91-419
Beschreibung:
Protein Delta Homolog 1 (DLK-1) is a transmembrane protein which contains a signal peptide, an extracellular domain with six tandem epidermai growth factor (EGF)-like domains, a single pass transmembrane domain, and a short cytoplasmic tail. It is found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. In addition, it is detected in some forms of neuroendocrine lung tumor tissue. DLK-1 may have a improtant role in neuroendocrine differentiation.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5221P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5221P
Lokale Artikelnummer::
PRSI5221P
Beschreibung:
AFAP1L2 peptide is used for blocking the activity of AFAP1L2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7269P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7269P
Lokale Artikelnummer::
PRSI7269P
Beschreibung:
17 amino acid peptide near the center of human PRKCDBP.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-265)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-265
Lokale Artikelnummer::
PRSI92-265
Beschreibung:
Ferritin is a large, iron-storage heteropolymeric protein,which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin has oligomer of 24 subunits and two types of subunits including light chain(FTL) and heavy chain. Ferritin can remove Fe (Ⅱ) from solution in the presence of oxygen and is very important for iron homeostasis. Iron is absorbed in the ferrous form and deposited as ferric hydroxides after oxidation. Iron is first oxidised to the ferric state for storage as ferric oxyhdroxide whithin the protein shell of ferritin. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms. Ferritin also plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-052)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-052
Lokale Artikelnummer::
PRSI96-052
Beschreibung:
Human recombinant Bace13 (from HEK293 cells)
VE:
1 * 200 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Neurotrophin-4 (NT-4) is an important member of the nerve growth factor (NGF) family of proteins. Neurotrophins undergo paracrine and autocrine signaling to control neuronal survival, neuronal differentiation, and dendrite outgrowth. NT-4 is expressed ubiquitously and signals through the TrkB receptor tryrosine kinase.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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