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1,8-Dihydroxynaphthalin
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1,8-Dihydroxynaphthalin
Artikel-Nr:
(EL0016)
Lieferant:
Thermo Fisher Scientific
Hersteller-Artikelnummer::
EL0016
Lokale Artikelnummer::
FERMEL0016
Beschreibung:
This T4 DNA ligase catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex DNA or RNA. The enzyme repairs single-strand nicks in duplex DNA, RNA, or DNA/RNA hybrids. It also joins DNA fragments with either cohesive or blunt termini, but has no activity on single-stranded nucleic acids.
VE:
1 * 1 KIT
Artikel-Nr:
(BOSSBS-0055R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0055R-A647
Lokale Artikelnummer::
BOSSBS-0055R-A647
Beschreibung:
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0072R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0072R-A488
Lokale Artikelnummer::
BOSSBS-0072R-A488
Beschreibung:
Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12319R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12319R-A555
Lokale Artikelnummer::
BOSSBS-12319R-A555
Beschreibung:
Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0072R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0072R-A555
Lokale Artikelnummer::
BOSSBS-0072R-A555
Beschreibung:
Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Stabilized with copper
Artikel-Nr:
(ENZOADISAB300J)
Lieferant:
ENZO LIFE SCIENCES
Hersteller-Artikelnummer::
ADISAB300J
Lokale Artikelnummer::
ENZOADISAB300J
Beschreibung:
Immunoglobulin G (IgG) is an immunoglobulin monomer consisting of two (gamma) heavy chains and two light chains. Each IgG molecule contains two antigen binding domains and a single effector (Fc) domain. Assay designs offers isotyping kits and antibodies in a variety of formats for the detection of human, mouse, rabbit, rat, sheep, and goat IgG.
VE:
1 * 1 mL
Artikel-Nr:
(BOSSBS-8546R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8546R-A680
Lokale Artikelnummer::
BOSSBS-8546R-A680
Beschreibung:
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localisation of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilisation. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8546R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8546R-A488
Lokale Artikelnummer::
BOSSBS-8546R-A488
Beschreibung:
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction, and cell junction stabilization. Plays a role in integrin signaling via its interaction with ITGB1BP1; this prevents the interaction between ITGB1 and ITGB1BP1. Microtubule-associated protein that binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
VE:
1 * 100 µl
Artikel-Nr:
(700-0842)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI700-0842
Beschreibung:
Mit seinem Breitformat-Gelsystem ist das Midi EXW ideal, wenn ein großer Probendurchsatz (bis zu 200) mit kurzen Laufzeiten notwendig ist, zum Beispiel bei der Genotypisierung. Eine spezielle Anordnung der Platinelektroden ermöglicht kurze Laufzeiten ohne dabei Kompromisse bei der Leistung hinnehmen zu müssen. Das Ergebnis ist ein System für die Probenverarbeitung mit ausgezeichneter Auflösung und überaus scharfen und klaren Banden. Wie bei allen PerfectBlue Gelsystemen können die Gele bei Temperaturen bis zu +60 °C direkt in die Gelträger gegossen werden. Beim Midi ExW können die Gelträger mit den Abschlusswänden "End Gates", gehören zum Lieferumfang, abgedichtet werden. Zusätzlich kann das Gelformat durch Verwendung der Trennwände oder der Aluminium-Gießschiene verkleinert werden.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-7553R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7553R-CY5
Lokale Artikelnummer::
BOSSBS-7553R-CY5
Beschreibung:
Eph receptor A2 is the receptor for members of the ephrin-A family. It binds to ephrin-A1, -A3, -A4 and -A5. Eph receptor A3 is also a receptor for members of the ephrin-A family. It binds to ephrin-A2, -A3, -A4 and -A5 and is thought to play a role in lymphoid function. Eph receptor A4 is a receptor for members of the ephrin-A family. It binds to ephrin-A1, -A4 and -A5. It binds more poorly to ephrin-A2 and -A3. It may play a role in a signal transduction process involved in hindbrain pattern formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0802R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-CY5.5
Lokale Artikelnummer::
BOSSBS-0802R-CY5.5
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Ranitidine hydrochloride 99%
Artikel-Nr:
(BOSSBS-7696R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7696R
Lokale Artikelnummer::
BOSSBS-7696R
Beschreibung:
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3921R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3921R-A750
Lokale Artikelnummer::
BOSSBS-3921R-A750
Beschreibung:
The ADCY4 gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyse the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7696R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7696R-CY3
Lokale Artikelnummer::
BOSSBS-7696R-CY3
Beschreibung:
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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