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1-Butansulfonylchlorid
Artikel-Nr:
(BOSSBS-11360R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11360R-A555
Lokale Artikelnummer::
BOSSBS-11360R-A555
Beschreibung:
Rim4 (Rab 3 interacting molecule 4), also known as Rim4 or regulating synaptic membrane exocytosis protein 4, is a 269 amino acid protein that localizes to the cell junction and regulates synaptic membrane exocytosis.Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis. Rab 3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (Rab 3 interacting molecule), a putative effector protein for Rab 3 proteins, is thought to regulate neutrotransmitter release through its interaction with Rab 3 and other synaptic proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7011R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7011R-A350
Lokale Artikelnummer::
BOSSBS-7011R-A350
Beschreibung:
The exact function of SDCCAG8 remains unknown. It is expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0697R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0697R-A680
Lokale Artikelnummer::
BOSSBS-0697R-A680
Beschreibung:
C-Phycocyanin (CPC), a pigment-protein complex from the light-harvesting phycobiliprotein family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8273R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8273R-HRP
Lokale Artikelnummer::
BOSSBS-8273R-HRP
Beschreibung:
The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP7 (GTPase IMAP family member 7), also known as IAN7 (immunity-associated nucleotide 7), is a 300 amino acid protein encoded by a gene that maps to human chromosome 7q36.1. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10097R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10097R-HRP
Lokale Artikelnummer::
BOSSBS-10097R-HRP
Beschreibung:
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5036R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5036R-HRP
Lokale Artikelnummer::
BOSSBS-5036R-HRP
Beschreibung:
Apolipoprotein C-II (apoCII) is in found in chylomicrons (large lipoprotein particles absorbed from the gastrointestinal tract) and VLDL (large lipoproteins that are broken down to eventually form LDL). ApoCII activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2901R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2901R-CY3
Lokale Artikelnummer::
BOSSBS-2901R-CY3
Beschreibung:
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0415R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0415R-HRP
Lokale Artikelnummer::
BOSSBS-0415R-HRP
Beschreibung:
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP1, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6091R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6091R-A488
Lokale Artikelnummer::
BOSSBS-6091R-A488
Beschreibung:
RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6464R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6464R-A750
Lokale Artikelnummer::
BOSSBS-6464R-A750
Beschreibung:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9312R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9312R-A680
Lokale Artikelnummer::
BOSSBS-9312R-A680
Beschreibung:
DIP2A, also known as DIP2, is a 1571 amino acid nuclear protein. It is one of three human homologs (DIP2A, DIP2B and DIP2C) of the Drosophila dip2 (disconnected-interacting protein 2) protein. In Drosophila, dip2 interacts with disco, a protein required for neuronal connections in the visual systems of larvae and adults. The closest vertebrate homologs to disco are the basonuclin genes. In mice, DIP2 homologs show restricted expression to the brain. This suggests that, similar to the function of Drosophila dip2, vertebrate DIP2 homologs may play a role in the development of the nervous system. Expressed ubiquitously with highest expression in the brain, DIP2A is thought to function in signaling throughout the central nervous system by providing positional clues for axon patterning and pathfinding. Four isoforms of DIP2A exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3253R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3253R-A555
Lokale Artikelnummer::
BOSSBS-3253R-A555
Beschreibung:
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15194R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15194R-A350
Lokale Artikelnummer::
BOSSBS-15194R-A350
Beschreibung:
Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes. The C4orf46 gene product has been provisionally designated C4orf46 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5292R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5292R-A680
Lokale Artikelnummer::
BOSSBS-5292R-A680
Beschreibung:
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED3 protease family. A novel DD containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx is a death domain containing important intermediate in the Fas mediated apoptosis. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N terminal kinase (JNK) pathway. It is widely expressed in foetal and adult human and mouse tissue, indicating its important function in Fas signaling pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5802R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5802R-A350
Lokale Artikelnummer::
BOSSBS-5802R-A350
Beschreibung:
Caspase 2 has a positive and a negative role in the regulation of the apoptotic process. Overexpression of the full length Caspase 2 (Nedd2/Ich1) mRNA in some cell types results in apoptosis, whereas overexpression of an alternative Caspase 2 splice variant suppresses apoptosis induced by serum withdrawal. Caspase 2 may be activated in vitro by Caspase 1, Caspase 3 and the neutral serine protease granzyme B which is stored in the specialized lytic granules of cytotoxic lymphocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11255R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11255R-A647
Lokale Artikelnummer::
BOSSBS-11255R-A647
Beschreibung:
Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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