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Methylorange
Artikel-Nr:
(BOSSBS-1638R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1638R-CY3
Lokale Artikelnummer::
BOSSBS-1638R-CY3
Beschreibung:
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1814R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1814R-CY7
Lokale Artikelnummer::
BOSSBS-1814R-CY7
Beschreibung:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13265R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13265R-A350
Lokale Artikelnummer::
BOSSBS-13265R-A350
Beschreibung:
GALE is a 348 amino acid protein that functions as the third enzyme in the Leloir pathway of galactose metabolism. A member of the sugar epimerase family, GALE exists as a homodimer, binds FAD as a cofactor and catalyzes the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine and UDP-glucose to UDP-galactose. The gene encoding GALE maps to human chromosome 1p36.11 and mutations in this gene lead to the development of complex disorder known as epimerase-deficiency galactosemia (EDG) or galactosemia type 3, which is characterized by mental retardation, liver damage, cataracts and deafness.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4862R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4862R
Lokale Artikelnummer::
BOSSBS-4862R
Beschreibung:
SORBS2 is an adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. It can form a complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6811R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6811R-A488
Lokale Artikelnummer::
BOSSBS-6811R-A488
Beschreibung:
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0553R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0553R-CY3
Lokale Artikelnummer::
BOSSBS-0553R-CY3
Beschreibung:
Collagen VI acts as a cell-binding protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9512R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9512R-A350
Lokale Artikelnummer::
BOSSBS-9512R-A350
Beschreibung:
Protein S (PROS) is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated protein C (APC) and facilitates clearance of early apoptotic cells. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Calcium-dependent association of C4BP-Protein S with apoptotic cells influences the regulation of complement activation. Protein S has APC-independent anticoagulant activity through direct inhibition of prothrombin activation via interactions with Factor X A, Factor V A and phospholipids. Autosomal dominant Protein S deficiency (levels 15 to 37% of normal) correlates with severe recurrent venous thrombosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5398R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5398R-A750
Lokale Artikelnummer::
BOSSBS-5398R-A750
Beschreibung:
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15151R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15151R
Lokale Artikelnummer::
BOSSBS-15151R
Beschreibung:
C2orf50 (chromosome 2 open reading frame 50), also known as FLJ25143 or MGC149401, is a 162 amino acid protein that is encoded by a gene located on human chromosome 2p25.1. The second largest human chromosome, chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstré°‰ syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes seen in modern form today in apes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2658R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2658R-A488
Lokale Artikelnummer::
BOSSBS-2658R-A488
Beschreibung:
May act as receptor for class I MHC antigens.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0196R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0196R-A750
Lokale Artikelnummer::
BOSSBS-0196R-A750
Beschreibung:
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1041R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1041R-A750
Lokale Artikelnummer::
BOSSBS-1041R-A750
Beschreibung:
MAP2K1
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5317R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5317R-CY5
Lokale Artikelnummer::
BOSSBS-5317R-CY5
Beschreibung:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2556R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2556R-A680
Lokale Artikelnummer::
BOSSBS-2556R-A680
Beschreibung:
May play a role in dendritic cell function and in adaptive immunity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3309R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3309R-CY7
Lokale Artikelnummer::
BOSSBS-3309R-CY7
Beschreibung:
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0814R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0814R-CY7
Lokale Artikelnummer::
BOSSBS-0814R-CY7
Beschreibung:
Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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