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Artikel-Nr:
(BOSSBS-6582R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6582R-A680
Lokale Artikelnummer::
BOSSBS-6582R-A680
Beschreibung:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesises mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6581R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6581R-A680
Lokale Artikelnummer::
BOSSBS-6581R-A680
Beschreibung:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesises mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6582R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6582R-A750
Lokale Artikelnummer::
BOSSBS-6582R-A750
Beschreibung:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesises mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
VE:
1 * 100 µl
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Zinkfluorid, wasserfrei 99%
Artikel-Nr:
(BOSSBS-0282R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0282R-CY5
Lokale Artikelnummer::
BOSSBS-0282R-CY5
Beschreibung:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0282R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0282R-CY3
Lokale Artikelnummer::
BOSSBS-0282R-CY3
Beschreibung:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
VE:
1 * 100 µl
Lieferant:
Sartorius Balances
Beschreibung:
Diese Ultramikrowaagen aus der Cubis® II-Reihe sind für hochpräzises Wägen von Mengen im Mikrogrammbereich vorgesehen. Es sind außerdem Modelle speziell für Filterwägeanwendungen erhältlich.
Artikel-Nr:
(BOSSBS-8560R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8560R-A488
Lokale Artikelnummer::
BOSSBS-8560R-A488
Beschreibung:
Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.
VE:
1 * 100 µl
Lieferant:
Sartorius Balances
Beschreibung:
Die Laborwaagen Cubis® II sind modular aufgebaut und bieten die Wahl zwischen Anwendungen und Konfigurationen, die den Bedürfnissen der Benutzer am besten entsprechen. Diese Waagen können auf der Ebene der Anzeige, des Windschutzes, der Softwareanwendungen und der Hardwarefunktionen konfiguriert werden. Die Hochleistungs-Mikrowaagen der Cubis® II-Reihe mit einer maximalen Wägelast zwischen 32 und 111 g und einer Ablesbarkeit zwischen 0,001 mg und 0,002 mg sind die ideale Wahl für ein breites Anwendungsspektrum.
Artikel-Nr:
(BOSSBS-12414R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12414R-A555
Lokale Artikelnummer::
BOSSBS-12414R-A555
Beschreibung:
MISR II is a 573 amino acid protein encoded by the human gene AMHR2. MISR II belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily and contains one protein kinase domain. Upon ligand binding, MISR II forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. These type II receptors rylate and activate type I receptors which autophosphorylate, then bind and activate Smad transcriptional regulators. MISR II also acts as a receptor for anti-Muellerian hormone. Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS-2). PMDS-2 is a form of male pseudo-hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
VE:
1 * 100 µl
Artikel-Nr:
(USBIE3500-90B)
Lieferant:
US Biological
Hersteller-Artikelnummer::
E3500-90B
Lokale Artikelnummer::
USBIE3500-90B
Beschreibung:
Anti-Escherichia coli, Verotoxin II Mouse Monoclonal Antibody [clone: 10C157]
VE:
1 * 100 µG
Artikel-Nr:
(BOSSBS-8585R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8585R-HRP
Lokale Artikelnummer::
BOSSBS-8585R-HRP
Beschreibung:
Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0282R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0282R-FITC
Lokale Artikelnummer::
BOSSBS-0282R-FITC
Beschreibung:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0282R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0282R-A488
Lokale Artikelnummer::
BOSSBS-0282R-A488
Beschreibung:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Zinkselenid ≥99,99% (Metall-Basis)
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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