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Proteine und Peptide
Artikel-Nr:
(PRSI91-150)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-150
Lokale Artikelnummer::
PRSI91-150
Beschreibung:
40S Ribosomal Protein S19 (RPS19) is a ribosomal protein that Belongs to the ribosomal protein S19e family. RPS19 is located in the nucleoli, and higher level expression is seen in colon carcinoma tissue than normal colon tissue. It required for pre-rRNA processing and maturation of 40S ribosomal subunits. RPS19 plays a role in many biological processes, such as endocrine pancreas development, erythrocyte differentiation, mRNA metabolic process. Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1), which is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7001P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7001P
Lokale Artikelnummer::
PRSI7001P
Beschreibung:
RGS22 peptide is used for blocking the activity of RGS22 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-286)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-286
Lokale Artikelnummer::
PRSI90-286
Beschreibung:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI92-279)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-279
Lokale Artikelnummer::
PRSI92-279
Beschreibung:
Heat shock protein beta-2(HSPB2) is a protein that in humans is encoded by the HSPB2 gene. HSPB2 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. It is expressed preferentially in the heart and skeletal muscle. HSPB2 has been shown to interact with TRAF6, HSPB8, Myotonic dystrophy protein kinase and CRYAB. HSPB2 regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-768)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-768
Lokale Artikelnummer::
PRSI91-768
Beschreibung:
CD99 Antigen-Like Protein 2 (CD99L2) belongs to the CD99 family. CD99L2 is a single-pass type I membrane protein and expressed in many tissues, with low expression in thymus. CD99L2 plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-343)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-343
Lokale Artikelnummer::
PRSI90-343
Beschreibung:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. PARP-1 (E998K mutant) is an inactive form of PARP-1 which can be used as a control compound.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI92-311)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-311
Lokale Artikelnummer::
PRSI92-311
Beschreibung:
FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-960)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-960
Lokale Artikelnummer::
PRSI91-960
Beschreibung:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4855P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4855P
Lokale Artikelnummer::
PRSI4855P
Beschreibung:
Stk39 peptide is used for blocking the activity of Stk39 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7249P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7249P
Lokale Artikelnummer::
PRSI7249P
Beschreibung:
16 amino acid peptide near the carboxy terminus of human RRAS2.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-510)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-510
Lokale Artikelnummer::
PRSI90-510
Beschreibung:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI4483P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4483P
Lokale Artikelnummer::
PRSI4483P
Beschreibung:
Slitrk4 peptide is used for blocking the activity of Slitrk4 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-052)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-052
Lokale Artikelnummer::
PRSI92-052
Beschreibung:
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-336)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-336
Lokale Artikelnummer::
PRSI90-336
Beschreibung:
TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerised TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signalling complex (DISC).
VE:
1 * 20 µG
Artikel-Nr:
(PRSI40-567)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-567
Lokale Artikelnummer::
PRSI40-567
Beschreibung:
RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI91-337)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-337
Lokale Artikelnummer::
PRSI91-337
Beschreibung:
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen Kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein.
VE:
1 * 50 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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