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Anti-TOX3 Mouse Monoclonal Antibody (CF405S) [clone: TOX3/1123]

Lieferant: Biotium
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BNC041123-500 BNC041123-100
BNC041123-500EA 560 EUR
BNC041123-500 BNC041123-100
Anti-TOX3 Mouse Monoclonal Antibody (CF405S) [clone: TOX3/1123]
Antikörper
This antibody recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2 -dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Type: Primary
Antigen: TOX3
Clonality: Monoclonal
Clone: TOX3/1123
Conjugation: CF405S
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
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