M-Clarity™ Qualitätsstufe = MQ200
B1760-1G
B1760-100MG
B1760-500MG
B1760-5G
SIALB1760-1GEA
500
EUR
InStock
SIALB1760-1G
SIALB1760-100MG
SIALB1760-500MG
SIALB1760-5G
Benzo[a]pyren ≥96% (durch HPLC), Sigma-Aldrich®
Benzo[a]pyren
Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer.
Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.