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FLUO 3/AM ≥95% (durch HPLC) fluoreszierender Indikator, zur Kalziumbestimmung

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FLUO 3/AM ≥95% (durch HPLC) fluoreszierender Indikator, zur Kalziumbestimmung
FLUO 3/AM
Membrane-permeant AM ester form of Fluo-3 that can be loaded into cells via incubation. Fluo-3 AM ester itself does not bind Ca2 , but it is readily hydrolyzed to Fluo-3 by endogenous esterases once the dye is inside the cells. An important application of Fluo-3 AM ester is its use in high throughput drug screening.

  • Abs/Em (after hydrolysis): 506/526 nm (low or high [Ca2 ] )
  • Extinction Coefficient (after hydrolysis): 86,000 M-1 cm-1 (506 nm)
  • Kd (Ca2 ) (after hydrolysis): 450 nM
  • Cell permeability: Membrane permeant
  • Orange red solid soluble in DMSO
  • Store -20°C and protect from light, especially when in solution

Because of the relatively low water solubility of the AM ester, Pluronic F-127, a mild detergent, is often used as a dispersing agent to facilitate dye loading. See the product information sheet for more information.


Formel: C₅₁H₅₀Cl₂N₂O₂₃
MW: 1129.85 g/mol
Storage Temperature: Gefrierschrank
 CAS-Nummer: 121714-22-5
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These terms and conditions cover all sales of products and services by VWR International Ltd (VWR) in the United Kingdom and any information and advice given whether charged for or not, unless otherwise agreed by VWR in writing. These terms and conditions apply to the exclusion of any other terms submitted by the customer or which are implied by any trade, custom, practice or course of dealing.

Customer Accounts

VWR’s products can be hazardous and all customers are required to comply with the VWR account application procedures which are available on request. VWR reserves the right immediately to cancel any orders from customers who have not complied in full with these procedures.

Ordering

The customer’s order for the products and/or services is an offer by the customer to purchase those products and/or services in accordance with these terms and conditions and shall only be deemed accepted when VWR issues written acceptance of the order, at which point the contract between the customer and VWR for the supply of those products and/or services, comes into existence (contract).

Any additional or special terms included by VWR in its written acceptance shall form part of the contract. The terms and conditions of the contract apply equally to the supply of both products and services except where application to one or the other is specified.

Should VWR need to supply products and/or services of different specifications, sources, and pack size to that published or ordered by the customer, VWR shall do so only after consultation with and agreement by the customer.

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Notwithstanding the foregoing paragraph, if there is a change of more than 3% to the rate of exchange of Sterling against foreign currencies including, but not limited to, the Euro and US Dollar since the date of receipt of an order then VWR may require the customer to renegotiate the prices relating to the relevant order.  Should VWR and the customer be unable to agree new prices within 7 days of receipt by the customer of a request in writing by VWR to renegotiate the price then VWR may terminate the contract with immediate effect by giving written notice to the customer.

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Customers who exceed their credit limits will be asked to pay in advance for additional products and/or services until the account is settled.

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Delivered products will remain the property of   VWR until the customer has paid for them.

VWR has the right to deliver an order in instalments (which may be invoiced and paid for separately). Any delay or defect in an instalment does not give the customer the right to cancel other instalments.

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Return of Damaged or Unsuitable Goods

No goods may be returned to VWR without the authorisation of VWR.

Authorisation to return products damaged during delivery must be requested within 3 days of delivery. VWR has the right to repair and return damaged products.

Authorisation for the return of products which fail to meet current published manufacturer’s specifications must be requested in writing within 28 days of delivery. VWR will assist customers, at customers’ expense, to obtain any manufacturer’s warranty consistent with that granted to VWR.

Authorisation for the return of products, other than those damaged during delivery, delivered in error or those that do not meet specification, must be requested within 10 days of delivery. Credit (less a handling charge of 15% of the invoice value of all products returned subject to a minimum charge of £30) will be given for those products authorised for return which are unused and in re-saleable condition other than those in the categories shown:-

  • open chemicals or diagnostics
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Authorisation will be subject to the condition that the products are returned to VWR Customer Service Centre or to the manufacturer or other source and by the method advised by VWR.

Articles that have been delivered on VWR’s behalf by a third-party supplier will not be accepted back at the VWR Customer Service Centre.

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Risk in products will pass at the time of delivery to the customer.
The customer is responsible for unloading and transporting large and/or heavy items from delivery vans and for supervising the unloading of all other products delivered.

In view of the hazards of certain chemicals and apparatus the customer must ensure that the products purchased are in a safe condition and that a safe system of work is in place taking into account all available information. None of the products sold are intended for human consumption unless otherwise clearly stated.
In view of the wide range of uses of chemicals and apparatus, the customer will be solely responsible for determining the suitability and specification of products, services, information and advice for its purposes.

Nothing in this contract shall limit or exclude VWR’s liability for death or personal injury caused by its negligence, fraud, fraudulent misrepresentation, or any other matter in respect of which it would be unlawful for VWR to exclude or restrict liability. Subject to this, in view of the responsibilities of the customer set out in the above paragraphs:

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Any liability accepted by VWR under this contract is in lieu of any terms implied by law as to the quality or fitness for any particular purpose of the products and/or the standard of the services and all such implied terms are, to the fullest extent permitted by law, excluded from the contract between VWR and the customer. The customer shall indemnify VWR against any claims made against VWR by the customer’s employees, contractors or agents.

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Without limiting its other rights and remedies, VWR may terminate the contract with immediate effect or suspend deliveries of the products, by giving written notice to the customer if the customer has failed to pay any amount owed to VWR on its due date for payment and remains in default for 14 days after notification to make payment, or if the customer has suffered or is likely to suffer an insolvency event or its financial position deteriorates to such an extent that in VWR’s opinion, the customer’s capacity adequately to fulfill its obligations under the contract is in question.

On termination of the contract for any reason the customer shall immediately pay to VWR all of its outstanding unpaid invoices and interest.

Confidentiality

Each of VWR and the customer undertakes to the other that it shall not disclose to any person any confidential information concerning the business, affairs, customers or suppliers of the other except to its employees or advisers who need to know the information in order to carry out its obligations under this contract, or as may be required by law, a court of competent jurisdiction or any governmental or regulatory authority.

Governing law

This contract shall be governed by and construed in accordance with the laws of England and Wales and each of VWR and the customer irrevocably agrees with the other that the courts of England and Wales shall have exclusive jurisdiction to settle any dispute arising under or in connection with it.

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