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tert-Butyl-N-methylcarbamate
Artikel-Nr:
(PRSI91-349)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-349
Lokale Artikelnummer::
PRSI91-349
Beschreibung:
The human Polymeric Immunoglobulin Receptor (pIgR) is a 100 kDa type I transmembrane glycoprotein. Its precursor is 764 amino acids. It contains an 18 amino acid signal sequence, a 620 amino acid extracellular region, a 23 amino acid transmembrane fragment, and a 103 amino acid cytoplasmic domain. pIgR is synthesized by secretory epithelial cells with five Ig-like domains in extracellular region, and transfer to the basolateral plasma membrane. For IgA and IgM polymers, in addition to alpha-heavy chains and light Ig chains, a short polypeptide named joining chain (J chain) is also contained and required. pIgR can bind larger polymers of IgA (pIgA) and pentameric IgM as a carrier that transports IgA and IgM across epithelium. The receptor-ligand complexes are endocytosed and transcytosed to the apical surface, then proteolytic cleavage of the sixth extracellular domain of pIgR and generate secretory IgA (SIgA), the pIgR fragment is referred to as secretory component (SC). SIgA is a important component of the mucosal immune system. SC is anti-microbial properties and protects SIgA from proteolytic degradation
VE:
1 * 50 µG
Lieferant:
GRANT INSTRUMENTS
Beschreibung:
The Optima™ range of advanced thermostats can be combined with plastic baths, premium stainless steel baths or refrigeration units. The TX150 and TXF200 thermostats feature a full colour QVGA TFT screen displaying actual and set temperature and clear status icons. The QVGA TFT screen, in combination with the easy to use dial and function keys, allows rapid navigation through the intuitive menu system. Both units have RS232 and USB interfaces and can be programmed via remote PC or laptop using Grant’s versatile Labwise™ software (optional). Additional features include countdown timer, adjustable over-temperature cut-out, visual, audible and programmable high and low temperature alarms. The TX150 has the capacity to store one program with 30 segments. The TXF200 can also be programmed via the user interface and can store up to 10 programs containing 100 segments. The programming interface includes set target temperature with a choice of time to target temperature or temperature ramp speed and an additional programmable relay for on/off control of ancillary equipment or refrigeration units.
Artikel-Nr:
(PRSI50-266)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
50-266
Lokale Artikelnummer::
PRSI50-266
Beschreibung:
Nop1p was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae. The Nop1p protein is 327 amino acids in size (34.5 kDa), is essential for yeast viability, and is localized in the nucleoli. The systematic name for S. cerevisiae Nop1 is YDL014W, and it is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. Patients with the autoimmune disease scleroderma often have strong circulating autoantibodies to a ~34 kDa protein which was subsequently found to be fibrillarin. Recent studies show that knock-out of the fibrillarin gene in mice results in embryonic lethality, although mice with only one functional fibrillarin/Nop1p gene were viable. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species (e.g. 4-6).
VE:
1 * 100 µl
Lieferant:
Simport Scientific
Beschreibung:
Röhrchen aus PP hergestellt, durchscheinend, glatt.
Lieferant:
VWR Chemicals
Beschreibung:
Yeast Nitrogen Base (YNB) is a base medium for preparation of minimal and synthetic defined yeast media.
Lieferant:
Sigma-Aldrich
Beschreibung:
(+)-Limonene 1,2-epoxide is a monoterpene that can be prepared from (+)-limonene has mixture of cis/trans-isomers. It shows potent antitumoral and antinociceptive activity. The main application is used as building block in synthesis of pharmaceutical products, perfumes, cosmetics and food additives.
Artikel-Nr:
(ABNOH00023308-M09)
Lieferant:
Abnova
Hersteller-Artikelnummer::
H00023308-M09
Lokale Artikelnummer::
ABNOH00023308-M09
Beschreibung:
Mouse monoclonal antibody raised against a partial recombinant ICOSLG.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI3423)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3423
Lokale Artikelnummer::
PRSI3423
Beschreibung:
Avian Influenza Neuraminidase Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. Novel influenza virus strains emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. Although it has been known that cleavage site and glycosylation patterns of the HA protein play important roles in determining the pathogenicity of H5 avian influenza viruses, it has only recently been shown that an additional glycosylation site within the globular head of the NA protein also contributes to the high virulence of the H5N1 virus.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI3761)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3761
Lokale Artikelnummer::
PRSI3761
Beschreibung:
LSD1 Antibody: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.
VE:
1 * 100 µG
Artikel-Nr:
(J64468.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J64468.03
Lokale Artikelnummer::
ALFAJ64468.03
Beschreibung:
2-Amino-6-chloropurine riboside 95%
VE:
1 * 1 g
Artikel-Nr:
(MOLE35359763-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
35359763-25G
Lokale Artikelnummer::
MOLE35359763-25G
Beschreibung:
di-Natrium-4-nitrophenylphosphat Hexahydrat (pNPP)
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
WATERS
Beschreibung:
These columns complement the ACQUITY BEH C18 and C8 phases and provide a necessary and powerful tool for HPLC method development. The embedded carbamate group in the bonded phase ligand provides alternate selectivity, especially for phenolic compounds compared to straight chain alkyl columns.
Artikel-Nr:
(HONE01102.9025)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01102.9025
Lokale Artikelnummer::
HONE01102.9025
Beschreibung:
Aluminiumfluorid
VE:
1 * 25 kg
Artikel-Nr:
(PRSI91-075)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-075
Lokale Artikelnummer::
PRSI91-075
Beschreibung:
Interleukin-33 (IL-33) was initially discovered as a nuclear factor NF-HEV abundantly expressed in high endothelial venules. It is a 30-32 kD pro-inflammatory protein with intracellular and extracellular activities and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 is highly and selectively expressed by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyers's patches, and lymph nodes. It contains a bipartite nuclear localization signal at the C-terminus, and is targeted to the nucleus when ectopically expressed in human umbilical vein endothelial cells (HUVECs) and HeLa cells. The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling. IL-33 mediates its biological effects via Toll-interleukin 1 (IL-1) receptor (TIR) domain-containing receptor ST2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. Human IL-33 is 270 amino acids in length.
VE:
1 * 50 µG
Artikel-Nr:
(HONE01277.9040)
Lieferant:
Honeywell Chemicals
Hersteller-Artikelnummer::
01277.9040
Lokale Artikelnummer::
HONE01277.9040
Beschreibung:
Aluminiumfluorid
VE:
1 * 40 kg
Artikel-Nr:
(PRSI79-340)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-340
Lokale Artikelnummer::
PRSI79-340
Beschreibung:
MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase. MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
VE:
1 * 100 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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