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1,4-Diazepan-6-amine
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1,4-Diazepan-6-amine
Artikel-Nr:
(BOSSBS-13356R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13356R-A555
Lokale Artikelnummer::
BOSSBS-13356R-A555
Beschreibung:
GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The protein p115 also binds p400, alternatively called giantin. Giantin, the majority of whose mass projects into the cytoplasm, is involved in the docking of COPI vesicles via p115 to the Golgi membrane. Giantin, which also is known as macrogolgin or Golgi complex-associated protein, is involved in cross-bridge formation in the Golgi complex. Giantin, which can form a homodimer, is a single-pass type I membrane protein that is an antigen in Sjoegren syndrome and in chronic rheumatoid arthritis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3953R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3953R-A647
Lokale Artikelnummer::
BOSSBS-3953R-A647
Beschreibung:
Cytochrome c oxidase subunit I (COI or MTCO1) is one of three mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. Complex IV is composed of 13 polypeptides. Subunits I, II, and III (MTCO1, MTCO2, MTCO3) are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb, VIIc, and VIII are nuclear encoded. Mammalian MTCO1 has 12 membrane-spanning alpha-helices (I to XII).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0025M-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0025M-A488
Lokale Artikelnummer::
BOSSBS-0025M-A488
Beschreibung:
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Three alternative splice variants of PSEN1 have been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9154R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9154R-A647
Lokale Artikelnummer::
BOSSBS-9154R-A647
Beschreibung:
The TRIAD3 gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6050R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6050R-A488
Lokale Artikelnummer::
BOSSBS-6050R-A488
Beschreibung:
TSC-36 is a secreted extracellular glycoprotein. The amino acid sequence of TSC-36 is similar to follistatin, an inhibitor of activin, as it contains a follistatin module. TSC-36 is a heparin-binding protein suggested to have a role in the negative regulation of cellular growth, as its expression is induced in response to TGF-b1. In addition, TSC-36 is not found in small cell lung cancer (SCLC) cells, a highly aggressive neoplasm, but is detected in some non-small cell lung cancer (NSCLC) cells, a moderately aggressive neoplasm.. May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13515R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13515R-A647
Lokale Artikelnummer::
BOSSBS-13515R-A647
Beschreibung:
Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9723R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9723R-A488
Lokale Artikelnummer::
BOSSBS-9723R-A488
Beschreibung:
The human augmin complex (HAUS) is an evolutionarily conserved 8-subunit protein complex that was initially discovered in Drosophila. The HAUS complex is essential for microtubule generation, centrosome integrity, mitotic spindle assembly and completion of cytokinesis. HAUS6 (HAUS augmin-like complex, subunit 6), also known as FAM29A or Dgt6, is a 955 amino acid component of the augmin complex. Required for mitotic progression, HAUS6 localizes to cytoplasm, cytoskeleton, mitotic spindle microtubules and interphase centrosomes, and undergoes post-translational phosphorylation following mitosis on multiple serine and threonine residues. HAUS6 exists as two alternatively spliced isoforms that are encoded by a gene located on human chromosome 9.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6770R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6770R-A488
Lokale Artikelnummer::
BOSSBS-6770R-A488
Beschreibung:
DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13152R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13152R-A555
Lokale Artikelnummer::
BOSSBS-13152R-A555
Beschreibung:
FCHO1 (FCH domain only 1) is an 889 amino acid protein that contains one FCH domain and exists as multiple alternatively spliced isoforms. The gene encoding FCHO1 maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fc receptors (FcRs). Key genes for eye color and hair color also map to chromosome 19.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4016R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4016R-A647
Lokale Artikelnummer::
BOSSBS-4016R-A647
Beschreibung:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2661R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2661R-A680
Lokale Artikelnummer::
BOSSBS-2661R-A680
Beschreibung:
MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1800R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1800R-A647
Lokale Artikelnummer::
BOSSBS-1800R-A647
Beschreibung:
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9078R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9078R-A350
Lokale Artikelnummer::
BOSSBS-9078R-A350
Beschreibung:
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10059R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10059R-A647
Lokale Artikelnummer::
BOSSBS-10059R-A647
Beschreibung:
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9972R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9972R-A750
Lokale Artikelnummer::
BOSSBS-9972R-A750
Beschreibung:
Leber congenital amaurosis (LCA) is one of the most common causes of hereditary blindness or severe visual impairment in infants. Mutations in several genes with diverse functions mapping to two loci have been implicated in LCA causation. These proteins are involved in processes such as photoreceptor development and maintenance, phototransduction, vitamin A metabolism and protein trafficking. LCA5, also known as Lebercilin, is a ciliary protein that is widely expressed during development and localizes to the connecting cilia of photoreceptors and to the microtubules, centrioles and primary cilia of cultured mammalian cells. The Leber congenital amaurosis 5-like protein (LCA5L) is a 670 amino acid protein that belongs to the LCA5 family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13357R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13357R-A647
Lokale Artikelnummer::
BOSSBS-13357R-A647
Beschreibung:
ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis. Two isoforms of ADRM1 exist due to alternative splicing events.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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