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2-Chloro-pyrido[2,3-b]pyrazine
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2-Chloro-pyrido[2,3-b]pyrazine
Artikel-Nr:
(BOSSBS-6457R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6457R-A555
Lokale Artikelnummer::
BOSSBS-6457R-A555
Beschreibung:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11384R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11384R-A555
Lokale Artikelnummer::
BOSSBS-11384R-A555
Beschreibung:
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8037R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8037R-A647
Lokale Artikelnummer::
BOSSBS-8037R-A647
Beschreibung:
COMMD is a new family of proteins with homology to MURR1, a multifunctional protein that inhibits NFkB. These proteins form multimeric complexes and were identified in a biochemical screen for MURR1-associated factors. The family is defined by the presence of a conserved and unique motif termed the COMM (copper metabolism gene MURR1) domain, which functions as an interface for protein-protein interactions. Down-regulates activation of NF-kappa-B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0747R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0747R-A680
Lokale Artikelnummer::
BOSSBS-0747R-A680
Beschreibung:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2885R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2885R-A750
Lokale Artikelnummer::
BOSSBS-2885R-A750
Beschreibung:
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1142R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1142R-A680
Lokale Artikelnummer::
BOSSBS-1142R-A680
Beschreibung:
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7729R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7729R-A488
Lokale Artikelnummer::
BOSSBS-7729R-A488
Beschreibung:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0111R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0111R-A750
Lokale Artikelnummer::
BOSSBS-0111R-A750
Beschreibung:
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4010R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4010R-A488
Lokale Artikelnummer::
BOSSBS-4010R-A488
Beschreibung:
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5037R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5037R-A647
Lokale Artikelnummer::
BOSSBS-5037R-A647
Beschreibung:
Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13313R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13313R-A680
Lokale Artikelnummer::
BOSSBS-13313R-A680
Beschreibung:
GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. The molecular weight of GFRP is approximately 9.5kDa although cross-linking experiments have shown that GFRP is usually found as a homodimer or as a pentamer. 15q15.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0527R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0527R-A555
Lokale Artikelnummer::
BOSSBS-0527R-A555
Beschreibung:
Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 3 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13136R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13136R-A680
Lokale Artikelnummer::
BOSSBS-13136R-A680
Beschreibung:
Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13367R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13367R-A350
Lokale Artikelnummer::
BOSSBS-13367R-A350
Beschreibung:
This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7583R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7583R-A647
Lokale Artikelnummer::
BOSSBS-7583R-A647
Beschreibung:
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5135R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5135R-A350
Lokale Artikelnummer::
BOSSBS-5135R-A350
Beschreibung:
CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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