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4-Brom-2-fluor-N-methylanilin+Hydrochlorid
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4-Brom-2-fluor-N-methylanilin+Hydrochlorid
Artikel-Nr:
(BOSSBS-8161R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8161R
Lokale Artikelnummer::
BOSSBS-8161R
Beschreibung:
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.Tissue specificity:Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11468R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11468R-CY3
Lokale Artikelnummer::
BOSSBS-11468R-CY3
Beschreibung:
Nogo is an oligodendrocyte-specific member of the Reticulon family and is a component of CNS white matter that inhibits axon outgrowth, induces collapse of growth cones of chick dorsal root ganglion cells, and inhibits the spreading of 3T3 fibroblasts. Nogo is expressed by oligodendrocytes but not by Schwann cells and associates primarily with the endoplasmic reticulum. Nogo exists in three different splice forms, Nogo-A, -B and -C. NgBR (Nogo-B receptor), also known as nuclear undecaprenyl pyrophosphate synthase 1 homolog, is a 293 amino acid single-pass type I membrane protein that acts as a specific receptor for the amino-terminus of Nogo-B. Through this interaction, NgBR is involved in the regulation of vascular remodeling and angiogenesis. NgBR also enhances Niemann-Pick type C2 protein (NPC2) stabilization. Knockdown of NgBR mRNA leads to decreased NPC2 levels, which results in the hallmarks of NPC2 mutation: increased intracellular cholesterol accumulation and a loss of sterol sensing.
VE:
1 * 100 µl
Lieferant:
Thermo Scientific
Beschreibung:
4-Amino-3-chlorbenzonitril
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
N-Fmoc-D-glutamic acid 5-tert-butyl ester 97%
Artikel-Nr:
(ENAMEN300107940.1G)
Lieferant:
SIA ENAMINE
Hersteller-Artikelnummer::
EN300107940.1G
Lokale Artikelnummer::
ENAMEN300107940.1G
Beschreibung:
1-Amino-2-methylnaphthalin
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
COMBI-BLOCKS
Beschreibung:
3-Amino-2-naphthalinmethanol
Artikel-Nr:
(ENAMEN300106785.1G)
Lieferant:
SIA ENAMINE
Hersteller-Artikelnummer::
EN300106785.1G
Lokale Artikelnummer::
ENAMEN300106785.1G
Beschreibung:
2-Amino-4-methoxybenzonitril
VE:
1 * 1 g
This is a MarketSource item. Additional charges may apply
Lieferant:
FLUOROCHEM
Beschreibung:
2-Amino-5-brompyridin
Lieferant:
Sigma-Aldrich
Beschreibung:
4-Amino-1-benzylpiperidin, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-6792R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6792R-CY5.5
Lokale Artikelnummer::
BOSSBS-6792R-CY5.5
Beschreibung:
The mammalian homologues of the key cell death gene CED 4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease activating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase 9 (Apaf3), which leads to caspase 9 activation. Activated caspase 9 in turn cleaves and activates caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. A new Apaf1 Interacting Protein (APIP) also known as CG129 and MMRP19, has been identified as a negative regulator of ischemic injury. APIP competes with Caspase 9 binding site of Apaf1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13189R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13189R-CY5
Lokale Artikelnummer::
BOSSBS-13189R-CY5
Beschreibung:
Amines, including those present on proteins, spontaneously react with glucose to make fructosamines in a reaction termed glycation. Fructosamine 3-kinase (FN3K), a 309-amino acid enzyme initially identified in erythrocytes, catalyzes the ATP-dependent phosphorylation of the third carbon on both D- and L-fructosamines, leading to their destabilization and eventually, their removal from the protein. FN3K is a monomer that is ubiquitously expressed in mammalian tissue and phosphorylates both low molecular mass and protein-bound fructosamines which are formed as a result of glycation of glucose with primary amines. FN3K protects proteins from the harmful effects of nonenzymatic glycation, and may also be involved in peptide repair and cell metabolism. FN3KRP (fructosamine-3-kinase-related protein) is a 309 amino acid protein that is expressed in erythrocytes, bone marrow, spleen, brain and kidney and belongs to the fructosamine kinase family. FN3KRP functions to phosphorylate psicoamines and ribulosamines on the third carbon of their sugar moiety, thereby leading to the deglycation of the target amines.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7961R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7961R-FITC
Lokale Artikelnummer::
BOSSBS-7961R-FITC
Beschreibung:
Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22–24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Dess Martin periodinane is used to oxidize primary alcohols to aldehydes and secondary alcohols to ketones. It is also used as an oxidant for complexes with multifunctional alcohols. It is actively involved in the oxidation of N-protected-amino alcohols without epimerization and allylic alcohols.
Lieferant:
COMBI-BLOCKS
Beschreibung:
2-Amino-6-methylbenzothiazol
Lieferant:
BIONET RESEARCH
Beschreibung:
4-Amino-3-fluorbenzoesäure
Artikel-Nr:
(J64758.03)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
J64758.03
Lokale Artikelnummer::
ALFAJ64758.03
Beschreibung:
3'-Amino-2',3'-dideoxyinosine 98%
VE:
1 * 1 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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