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2-(4-Pyridinyloxy)-ethanamine+hydrochloride
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2-(4-Pyridinyloxy)-ethanamine+hydrochloride
Artikel-Nr:
(BOSSBS-9051R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9051R-A555
Lokale Artikelnummer::
BOSSBS-9051R-A555
Beschreibung:
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) >K(+) >Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.Involvement in disease:Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4682R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4682R-A350
Lokale Artikelnummer::
BOSSBS-4682R-A350
Beschreibung:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4682R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4682R-A647
Lokale Artikelnummer::
BOSSBS-4682R-A647
Beschreibung:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1136R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1136R-CY5.5
Lokale Artikelnummer::
BOSSBS-1136R-CY5.5
Beschreibung:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1136R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1136R-CY7
Lokale Artikelnummer::
BOSSBS-1136R-CY7
Beschreibung:
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).[supplied by OMIM]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3798R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3798R-CY5.5
Lokale Artikelnummer::
BOSSBS-3798R-CY5.5
Beschreibung:
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3798R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3798R-CY3
Lokale Artikelnummer::
BOSSBS-3798R-CY3
Beschreibung:
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5161R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5161R-A647
Lokale Artikelnummer::
BOSSBS-5161R-A647
Beschreibung:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5161R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5161R-FITC
Lokale Artikelnummer::
BOSSBS-5161R-FITC
Beschreibung:
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11358R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11358R-A647
Lokale Artikelnummer::
BOSSBS-11358R-A647
Beschreibung:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-A488
Lokale Artikelnummer::
BOSSBS-6425R-A488
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-CY7
Lokale Artikelnummer::
BOSSBS-6425R-CY7
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-CY5
Lokale Artikelnummer::
BOSSBS-6425R-CY5
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6425R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6425R-CY5.5
Lokale Artikelnummer::
BOSSBS-6425R-CY5.5
Beschreibung:
Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11358R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11358R-FITC
Lokale Artikelnummer::
BOSSBS-11358R-FITC
Beschreibung:
RIMS-binding proteins (RIM-BPs) serve as adaptors during vesicle fusion and release by forming links between synaptic-vesicle fusion apparatuses and calcium channels. Specifically, RIM-BP2 (RIMS binding protein 2), also known as RBP2, is a 1,052 amino acid protein that links L-type Ca++ CP Alpha1D, N-type Ca++ CP Alpha1B, Rim1 and Rim2 during synaptic transmission. RIM-BP2 contains three fibronectin type-III domains and three SH3 domains, which are used to mediate binding to a proline-rich motifs. Existing as three alternatively spliced isoforms, RIM-BP2 is encoded by a gene that maps to human chromosome 12q24.33 and mouse chromosome 5 G1.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3666R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3666R-A488
Lokale Artikelnummer::
BOSSBS-3666R-A488
Beschreibung:
Calmodulin consists of two glycoproteins, 34 and 39 kDa, sometimes designated epithelial antigen, epithelial specific antigen, and epithelial glycoprotein. The glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. Epithelial Calmodulin is found in the large majority of adenocarcinomas of most sites (50-100% in various studies; as well as neuroendocrine tumours, including small cell carcinoma. Renal cell carcinoma and hepatocellular carcinoma stain in about 30% of the cases. Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin Ca(2+) complex are a number of protein kinases and phosphatases. Calmodulin has four functional calcium binding sites.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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