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(4-Isopropylphenoxy)acetyl+chloride
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(4-Isopropylphenoxy)acetyl+chloride
Lieferant:
Alfa Aesar
Beschreibung:
4-Brompyridiniumchlorid ≥99%
Lieferant:
Merck
Beschreibung:
Hydroxylammoniumchlorid ACS, ISO, Reag. Ph. Eur., GR zur Analyse, Supelco®
Artikel-Nr:
(BOSSBS-9446R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9446R-A488
Lokale Artikelnummer::
BOSSBS-9446R-A488
Beschreibung:
AMPK is a heterotrimeric complex comprising a catalytic a subunit and regulatory b and g subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKa1 and AMPKa2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKb1 encodes a 271 amino acid protein and human AMPKb2 encodes a 272 amino acid protein. The human AMPKg1 gene encodes a 331 amino acid protein. Human AMPKg2 and AMPKg3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Magnesiumchlorid, ultra trocken ≥99,99% (Metall-Basis)
Artikel-Nr:
(BOSSBS-13686R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13686R-FITC
Lokale Artikelnummer::
BOSSBS-13686R-FITC
Beschreibung:
MOZ (monocytic leukemia zinc finger protein) is a chromatin-associated histone acetyltransferase (HAT) that regulates chromatin remodeling and transcription. The MOZ gene was initially isolated as a consequence of two variant translocations that were identified in a distinct subtype of acute myeloid leukemias and resulted in the formation of MOZ fusion proteins. These fusions involve the HAT domain of MOZ with the activation domain of either transcriptional coactivator protein TIF2/GRIP1 or CBP, and lead to enhanced transcriptional activation by a mechanism involving aberrant histone acetylation. Additional MOZ related proteins, including MORF (MOZ related factor) and TIP60 (TAT interacting proteins 60), share significant similarities with MOZ including the putuative HAT domain. MORF also contains a strong transcriptional repression domain at its N terminus and a highly potent activation domain at the C terminus, suggesting that MORF has both HAT activity and contributes to the regulation of transcriptional activation. TIP60 was originally identified as a coactivator for the HIV TAT protein and also functions as a nuclear hormone receptor coactivator that enhances ligand dependent steroid receptor-mediated transactivation involving the androgen, estrogen and progesterone receptors.
VE:
1 * 100 µl
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
Toluidine blue (C.l. 52040) is a diaminothiazine dye. It is also known as TBO, tolonium chloride, and toluidine blue O.
Lieferant:
Alfa Aesar
Beschreibung:
Kaliumchlorid, Optische Qualität
Artikel-Nr:
(BOSSBS-9446R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9446R-A647
Lokale Artikelnummer::
BOSSBS-9446R-A647
Beschreibung:
AMPK is a heterotrimeric complex comprising a catalytic a subunit and regulatory b and g subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase and inhibition of dephosphorylation. Activated AMPK can phosphorylate and regulate in vivo hydroxy-methylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively. The human AMPKa1 and AMPKa2 genes encode 548 amino acid and 552 amino acid proteins, respectively. Human AMPKb1 encodes a 271 amino acid protein and human AMPKb2 encodes a 272 amino acid protein. The human AMPKg1 gene encodes a 331 amino acid protein. Human AMPKg2 and AMPKg3, which are 569 and 492 amino acid proteins, respectively, contain unique N-terminal domains and may participate directly in the binding of AMP within the AMPK complex.
VE:
1 * 100 µl
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
Fast blue BB salt für die Mikroskopie, für die Histologie, Sigma-Aldrich®
Lieferant:
Thermo Scientific
Beschreibung:
3-Acetylcumarin
Lieferant:
Merck
Beschreibung:
Natriumchlorid, Suprapur® für die Spurenanalyse, Supelco®
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-Pyridinsulfonylchlorid 98%
Artikel-Nr:
(BOSSBS-6060R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6060R-A350
Lokale Artikelnummer::
BOSSBS-6060R-A350
Beschreibung:
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Azure II (C.I. 52010/ 52015) is a dry dye for the preparation of a color staining solution used for the staining of blood and bone marrow smears of human origin. The dye is a CE certified IVD product and has a constant dye content and a reliable high quality, which is one of the major precondition for a reproducible diagnostic staining.
Lieferant:
Merck
Beschreibung:
Methylenblau Reag. Ph. Eur., Supelco®
Artikel-Nr:
(BOSSBS-2035R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2035R
Lokale Artikelnummer::
BOSSBS-2035R
Beschreibung:
Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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