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Artikel-Nr:
(BOSSBS-0534R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0534R-A555
Lokale Artikelnummer::
BOSSBS-0534R-A555
Beschreibung:
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
VE:
1 * 100 µl
Artikel-Nr:
(6043-25)
Lieferant:
MACRON AVANTOR BRAND
Lokale Artikelnummer::
MACR6043-25
Beschreibung:
2,2,4-Trimethylpentan ≥99,5%, ChromAR® für die Flüssigchromatographie, für die UV-Spektrophotometrie, Macron Fine Chemicals™
VE:
1 * 2,5 L
Artikel-Nr:
(BOSSBS-0518R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0518R-A555
Lokale Artikelnummer::
BOSSBS-0518R-A555
Beschreibung:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0518R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0518R-CY5.5
Lokale Artikelnummer::
BOSSBS-0518R-CY5.5
Beschreibung:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
VE:
1 * 100 µl
Lieferant:
Restek
Beschreibung:
Graphitisierter Ruß bietet eine einzigartige Selektivität und sehr geringe Adsorption für Alkoholanalysen. Es sind zwei Arten von CarboBlack-Trägern erhältlich: CarboBlack B und CarboBlack C. Der CarboBlack B-Träger mit seiner größeren Oberfläche kann bis zu 10% einer flüssigen Phase ohne Silikon aufnehmen. Der CarboBlack C-Träger kann bis zu 1% einer flüssigen Phase ohne Silikon aufnehmen.
Artikel-Nr:
(BOSSBS-3406R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3406R-CY7
Lokale Artikelnummer::
BOSSBS-3406R-CY7
Beschreibung:
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. The chromosome proteins are conserved in eukaryotes and can lead to mitotic chromosome segregation defects, suggesting a critical function of SMC family proteins in mitotic chromosome dynamics. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. Specifically this SMC1/SMC3 complex is responsible for sister chromatid cohesion during metaphase. A number of cellular factors interact with hSMC1/hSMC3 during cell cycle. The major population of hSMC1/hSMC3 is in a compex with hRAD21 forming the human cohesion complex. Human cohesion complex associates with chromosomes which peaks at S phase and dissociates from chromosomes during G2/M transition. In addition, a subpopulation of hSMC1/hSMC3 associates tightly with nuclear matrix and centrosomes during interphase. A subset of hSMC1/hSMC3 is localized to spindle poles, spindles and kinetochores during mitosis when cohesin is in the cytoplasm. hSMC1/hSMC3 is required for spindle aster formation in vitro and reacts with nuclear mitotic apparatus protein in vivo.
VE:
1 * 100 µl
Lieferant:
MACHEREY-NAGEL
Beschreibung:
Mittlere polare GC-Phase.
Lieferant:
VARIAN
Beschreibung:
OMIX automation-friendly 96-well monolithic SPE plates are specially designed to process small samples. They offer small extraction beds with almost no dead volume. Elution is achieved with microlitre solvent volumes, allowing direct injection and improving assay speed and sample throughput. OMIX tips are highly amenable to ADME/DMPK bioanalysis applications.
Lieferant:
Restek
Beschreibung:
This highly retentive and selective phase is developed specifically for the analysis of aldehydes and ketones as DNPH derivatives. Allure® AK is a reversed phase HPLC material that has the unique ability to separate all 13 carbonyl compounds using a simple acetonitrile/water gradient.
Lieferant:
MP Biomedicals
Beschreibung:
Circlegrow® is designed for obtaining rapid growth of <i>E. coli</i> and high yields of plasmid DNA. It extends plasmid production past log phase.
Lieferant:
MICROSOLV
Beschreibung:
Cogent TYPE-C Silica™ is HPLC grade silica with a silica hydride surface. Their unique stationary phase will adsorb and desorb solvents commonly used in mobile phases very differently from ordinary silica resulting in excellent benefits to the chromatographer. Excellent for normal phase chromatography and solvent drying is not needed.
Lieferant:
Thermo Fisher Scientific
Beschreibung:
The AquaSil™ C18 columns provide a versatile C18 phase for a wide range of applications. Combining a C18 phase with a hydrophilic end-capping, AquaSil™ C18 columns offer a unique material for reversed phase chromatography, offering alternative selectivity, up to twice the retention for polar compounds, and no phase collapse under 100% aqueous conditions. Ideal for use with LC/MS, these columns maintain selectivity with reduced concentrations of buffers and additives.
Artikel-Nr:
(MLDVMICRO4)
Lieferant:
Molecular Devices
Hersteller-Artikelnummer::
MICRO4
Lokale Artikelnummer::
MLDVMICRO4
Beschreibung:
Das ImageXpress Micro 4-High-Content-Zell-Imaging-System ist das Highlight von vier Generationen Imaging-Expertise. Sein flexibles Design ermöglicht es, Ihre Forschungsarbeiten mit einem System voranzutreiben das schneller ist als jemals zuvor. Darüber hinaus kann es zu einem konfokalen System aufgerüstet werden, wenn dies in Zukunft für Ihren Forschungsbedarf erforderlich ist.
VE:
1 * 1 ST
Lieferant:
Resonac
Beschreibung:
RSpak DS columns are suitable for reversed-phase analysis of highly hydrophilic substances, which cannot be retained well by ODS columns.
Artikel-Nr:
(BOSSBS-4636R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4636R-A488
Lokale Artikelnummer::
BOSSBS-4636R-A488
Beschreibung:
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8670R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8670R-HRP
Lokale Artikelnummer::
BOSSBS-8670R-HRP
Beschreibung:
The genus Salmonella is a member of the family Enterobacteriaceae. The genus is composed of Gram-negative bacilli that are facultative and flagellated (motile). Salmonellae possess 3 major antigens; the "H" or flagellar antigen (phase 1 & 2), the "O" or somatic antigen (part of the LPS moiety) and the "Vi" or capsular antigen (referred to as "K" in other Enterobacteriaceae). Salmonellae also possess the LPS endotoxin characteristic of Gram-negative bacteria. This LPS is composed of an "O" polysaccharide ("O" antigen) an "R" core and the endotoxic inner "Lipid A". Endotoxins evoke fever and can activate complement, kinin and clotting factors. The commonest Salmonella serotype associated with food borne infections in humans is Salmonella enteriditis and in particular phage type 4 (PT4). Salmonella Enteriditis bacteria may be found in the intestinal tracts of livestock, poultry, dogs, cats and other warm-blooded animals. This strain is only one of about 2,000 kinds of Salmonella bacteria; it is often associated with poultry and eggs.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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