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β-tri-Calciumphosphat+(β-Phase)
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β-tri-Calciumphosphat+(β-Phase)
Artikel-Nr:
(BOSSBS-13140R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13140R-A680
Lokale Artikelnummer::
BOSSBS-13140R-A680
Beschreibung:
Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2751R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2751R-A555
Lokale Artikelnummer::
BOSSBS-2751R-A555
Beschreibung:
Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localizes to the inner centromere region from prophase to anaphase. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.
VE:
1 * 100 µl
Lieferant:
Thermo Fisher Scientific
Beschreibung:
Flacher, 100% poröser Graphit-Kohlenstoff (PGC) mit Selektivität für strukturell ähnliche Verbindungen, ermöglicht die Trennung von Verbindungen mit einfachen Lösungsmitteln. Hydrophobe Umkehrphase; Normalphasen-Adsorption; polare Retention.
Artikel-Nr:
(BOSSBS-0518R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0518R-FITC
Lokale Artikelnummer::
BOSSBS-0518R-FITC
Beschreibung:
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
VE:
1 * 100 µl
Lieferant:
WATERS
Beschreibung:
These columns are suitable for a diverse range of analytes. With mobile phase (pH 1 to 12) and temperature (80 °C) compatibility, this trifunctionally-bonded alkyl column is a universal method development tool that can impact the retention, selectivity and sensitivity of ionisable compounds (with mobile phase pH) while delivering low- and high-pH stability for all analyte types.
Lieferant:
Thermo Scientific
Beschreibung:
This antibody labeling system uses nickel chelated agarose to temporarily immobilise antibody molecules via their histidine-rich Fc regions. Once held in place on the gel, the antibody can be biotinylated at either sulfhydryl groups (after mild reduction or disulfide bonds) or primary amines. Excess labeling reagent and by-products are then washed away before recovering the labeled and purified antibody from the gel using a mild imidazole solution. No gel filtration or dialysis are needed.
Lieferant:
Restek
Beschreibung:
Separations of more than one hundred chiral compounds have been achieved using our unique DEX columns, and DEX columns continue to demonstrate stability after hundreds of temperature program cycles. By adding β or γ cyclodextrin to our bonded Rtx-1701 stationary phase, we greatly enhance overall utility and column lifetime for our chiral columns, compared to columns that have pure cyclodextrin stationary phases. 2,3-di-O-ethyl-6-O-tert-butyl dimethylsilyl beta cyclodextrin added into 14% cyanopropylphenyl/86% dimethyl polysiloxane
Artikel-Nr:
(PRSI79-556)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-556
Lokale Artikelnummer::
PRSI79-556
Beschreibung:
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
VE:
1 * 100 µG
Lieferant:
MACHEREY-NAGEL
Beschreibung:
Hydrophobic reversed phase with distinct polar selectivity for special PFAS analysis. Suitability for PFAS analysis is assured through qualified batch analysis.
Lieferant:
MACHEREY-NAGEL
Beschreibung:
NUCLEOSIL® C8 HD is an octyl modified silica phase with a high density coverage, using for HPLC.
Lieferant:
OZ BIOSCIENCES
Beschreibung:
SqualVax is an oil-in-water emulsion made of squalene droplets in a continuous aqueous phase. It is an important advantage over alternative oils that have been used in emulsion adjuvants, like Freund’s adjuvant that contains mineral oil (paraffin oil) and has long term persistence in organisms.
Artikel-Nr:
(PRSI27-867)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-867
Lokale Artikelnummer::
PRSI27-867
Beschreibung:
The TFDP genes encode a family of transcription factors that can form heterodimers with E2F family proteins in vivo. The E2F-TFDP transcription factors are major regulators of genes that are required for the progression of S-phase, such as DHFR and DNA polymerase alpha, and they play a critical role in cell cycle regulation and differentiation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-559)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-559
Lokale Artikelnummer::
PRSI79-559
Beschreibung:
Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI26-902)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-902
Lokale Artikelnummer::
PRSI26-902
Beschreibung:
The specific function of FRK is not yet known.The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.
VE:
1 * 50 µG
Lieferant:
VARIAN
Beschreibung:
Bond Elut™ LMS polymeric sorbent lets you elute without having to add amine modifiers, buffers, or acids. The elimination of secondary interactions means that elution of analytes can be achieved with pure organic solvents or HPLC mobile phase-compatible solvent mixtures of low ionic strength. These characteristics are crucial to allow compatibility with LC/MS or other delicate analytical techniques.
Lieferant:
Restek
Beschreibung:
These traditional endcapped C18 columns are ideal for general-purpose use in reversed-phase chromatography.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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