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β-tri-Calciumphosphat+(β-Phase)
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β-tri-Calciumphosphat+(β-Phase)
Lieferant:
VARIAN
Beschreibung:
Agilent JW CP-Wax 58 FFAP CB column is a nitroterephthalic acid-modified, chemically bonded polyethylene glycol phase.
Lieferant:
VARIAN
Beschreibung:
Bond Elut™ LMS polymeric sorbent lets you elute without having to add amine modifiers, buffers, or acids. The elimination of secondary interactions means that elution of analytes can be achieved with pure organic solvents or HPLC mobile phase-compatible solvent mixtures of low ionic strength. These characteristics are crucial to allow compatibility with LC/MS or other delicate analytical techniques.
Artikel-Nr:
(BOSSBS-2993R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2993R-CY3
Lokale Artikelnummer::
BOSSBS-2993R-CY3
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(MICS84518-25P)
Lieferant:
MICROSOLV
Hersteller-Artikelnummer::
84518-25P
Lokale Artikelnummer::
MICS84518-25P
Beschreibung:
This polar embedded stable C18 column is useful when very high aqueous content mobile phases are required for retention of hydrophobic compounds.
VE:
1 * 1 ST
Lieferant:
MACHEREY-NAGEL
Beschreibung:
NUCLEODUR® C18 Pyramid ist eine Octadecyl-modifizierte Silica-Phase mit polarer Endkappe, speziell zur Verwendung mit bis zu 100% wässrige Eluenten entwickelt.
Artikel-Nr:
(WATE186002492)
Lieferant:
WATERS
Hersteller-Artikelnummer::
186002492
Lokale Artikelnummer::
WATE186002492
Beschreibung:
These Oasis® WAX cartridges contain the WAX sorbent, which is a polymeric reversed phase, weak anion exchange mixed mode sorbent that has been optimised for fast, simple, and highly selective sample preparation of strong acidic compounds.
VE:
1 * 100 ST
 This is a MarketSource item. Additional charges may apply
Lieferant:
VICI JOUR RESEARCH
Beschreibung:
Fiberglass reinforced PP with PP washers. A number of chromatography systems still require or prefer flanged connections. When the tubing is flanged, the washer never comes in contact with the mobile phase.
Artikel-Nr:
(BOSSBS-3195R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3195R-CY3
Lokale Artikelnummer::
BOSSBS-3195R-CY3
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3195R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3195R-CY5
Lokale Artikelnummer::
BOSSBS-3195R-CY5
Beschreibung:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0534R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0534R
Lokale Artikelnummer::
BOSSBS-0534R
Beschreibung:
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11267R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11267R-A750
Lokale Artikelnummer::
BOSSBS-11267R-A750
Beschreibung:
CCT2 is one of eight largely unrelated subunit proteins found in a protein chaperone complex known as the chaperonin-containing TCP-1 (CCT) or TRiC complex. The CCT complex is an abundanct cytoslic component that is credited with helping newly synthesised polypeptides adopt the correct conformation. Proteins that fold and assemble with the help of CCT include the cytoskeletal proteins actin and tubulin as well as up to 15% of newly synthesised eukaryotic proteins. CCT2 is the _-subunit of the chaperone complex and is one of several CCT proteins that exhibit increased expression in response to stress. This implies that the CCT complex helps cells recover from protein damage by assisting in protein folding and assembly. CCT subunit levels also change throughout the cell cycle, with lower proteins levels (and reduced chaperone activity) found during induced cell cycle arrest during at M phase. Each CCT subunit is thought to perform a specific function during protein folding and assembly; CCT2 exhibits both actin and tubulin binding activities but the exact molecular function on this subunit remains uncertain.
VE:
1 * 100 µl
Lieferant:
MEMMERT
Beschreibung:
Dieser Sterilisator stimmt mit allen relevanten Vorgaben und Vorschriften für medizinische Produkte überein und garantiert zuverlässige Programmabläufe, ungeachtet der Beladung und des Kammervolumens. Insbesondere ist die Überprüfung des Heißluftsterilisators , dank der SetpointWAIT Funktion, jederzeit möglich. Die SetpointWAIT Funktion stellt sicher das der Programmbeginn für das Sterilisieren erst bei Erreichen der Solltemperatur startet. Durch das genaue Einhalten der Sterilisationszeit ist die Elimination selbst hoch resistenter Mikroorganismen garantiert. Dieses Feature kann auch mit frei positionierbaren Pt100-Temperatursensoren genutzt werden. Hier beginnt die Sterilisierzeit erst bei Erreichen der Solltemperatur an allen Messpunkten und die zuverlässige Sterilisation ist zu jedem Zeitpunkt sichergestellt. Für die spezielle Anwendung der Entpyrogenisierung ist der Heißluftsterilisator ideal. Die Modelle der SF Reihe sind mit SingleDISPLAY ausgestattet.
Artikel-Nr:
(BOSSBS-5347R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5347R-FITC
Lokale Artikelnummer::
BOSSBS-5347R-FITC
Beschreibung:
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq].eIF4G1 (eukaryotic translation Initiation Factor 4 Gamma 1) is a component of the protein complex eIF-4 which is involved in the recognition of the mRNA cap ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of mRNA to the ribosome. eIF4G plays a critical role in protein expression and is at the center of a complex regulatory network. Together with the cap-binding protein eIF4E, it recruits the small ribosomal subunit to the 5'-end of mRNA and promotes the assembly of a functional translation initiation complex which scans along the mRNA to the translation start codon. Human eIF4G contains three consecutive HEAT domains, as well as long unstructured regions involved in multiple protein-protein interactions. The interactions of eIF4G1 with other factors are largely unknown.
VE:
1 * 100 µl
Lieferant:
Restek
Beschreibung:
Highly retentive and selective phase for separating polar analytes, including polar acidic compounds. Compatible with highly aqueous (upto 100%) mobile phases. Highly base deactivated.
Artikel-Nr:
(BOSSBS-3848R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3848R-CY5.5
Lokale Artikelnummer::
BOSSBS-3848R-CY5.5
Beschreibung:
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with DFNB31 and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes.
VE:
1 * 100 µl
Lieferant:
Agilent
Beschreibung:
GC-Säulen erreichen mit einzeln getesteten DB-WAX UI-Säulen die höchste Inertheitsleistung der stationären PEG-Phase für eine Reihe anspruchsvoller aktiver Analyten.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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