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PROSCI
Artikel-Nr:
(PRSI33-926)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-926
Lokale Artikelnummer::
PRSI33-926
Beschreibung:
Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor, which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI96-727)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-727
Lokale Artikelnummer::
PRSI96-727
Beschreibung:
Tumor necrosis factor receptor 1 (TNF-R1) is also known as Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), TNFAR, CD antigen CD120a, which belongs to the tumor necrosis factor receptor superfamily. TNF-R1 contains one death domain and four TNFR-Cys repeats. TNF-R1 is the receptor of TNFSF2 / TNF-alpha and homotrimeric TNFSF1 / lymphotoxin - alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNF-R1 contributes to the induction of non - cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Defects in TNFRSF1A are the cause of familial hibernian fever (FHF).
VE:
1 * 100 µG
Artikel-Nr:
(PRSI34-099)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-099
Lokale Artikelnummer::
PRSI34-099
Beschreibung:
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI79-916)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-916
Lokale Artikelnummer::
PRSI79-916
Beschreibung:
The MDC1 protein contains a forkhead homology-associated (FHA) domain and 2 BRCA1 (MIM 113705) C-terminal motifs (BRCTs) and is required for the intra-S-phase DNA damage checkpoint.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI6023)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6023
Lokale Artikelnummer::
PRSI6023
Beschreibung:
MFSD1 Antibody: Multidrug transporters, such as MFSD1, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that include uniporters, symporters, and antiporters. Members of this family are found in all living organisms and are highly represented in bacteria. MFS members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFS have provided important insight into the mechanism underlying multidrug transport. MFSD1 is still poorly understood.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI19-735)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
19-735
Lokale Artikelnummer::
PRSI19-735
Beschreibung:
Anti-RNF2 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI92-581)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-581
Lokale Artikelnummer::
PRSI92-581
Beschreibung:
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI35-148)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
35-148
Lokale Artikelnummer::
PRSI35-148
Beschreibung:
Anti-Clostridium Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 1 mL
Artikel-Nr:
(PRSI24-076)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-076
Lokale Artikelnummer::
PRSI24-076
Beschreibung:
Anti-Fluorescein (FITC) Recombinant Antibody [Clone: 4-4-20 (enhanced)]
VE:
1 * 0,2 mg
New Product
Artikel-Nr:
(PRSI96-651)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-651
Lokale Artikelnummer::
PRSI96-651
Beschreibung:
Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI24-767)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-767
Lokale Artikelnummer::
PRSI24-767
Beschreibung:
Anti-CD81 Recombinant Antibody [Clone: 1.3.3.22]
VE:
1 * 0,2 mg
New Product
Artikel-Nr:
(PRSI18-945)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
18-945
Lokale Artikelnummer::
PRSI18-945
Beschreibung:
Anti-NFKB2 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI5861)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5861
Lokale Artikelnummer::
PRSI5861
Beschreibung:
CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI42-700)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
42-700
Lokale Artikelnummer::
PRSI42-700
Beschreibung:
Anti-NEK7 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-248)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-248
Lokale Artikelnummer::
PRSI92-248
Beschreibung:
Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
VE:
1 * 0,05 mg
New Product
Artikel-Nr:
(PRSI19-809)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
19-809
Lokale Artikelnummer::
PRSI19-809
Beschreibung:
Anti-CS Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Preis auf Anfrage
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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