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1,1-Diphenylhydrazin+Hydrochlorid
Artikel-Nr:
(BOSSBS-2803R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2803R-A750
Lokale Artikelnummer::
BOSSBS-2803R-A750
Beschreibung:
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.
VE:
1 * 100 µl
Lieferant:
Merck
Beschreibung:
Natriumcarbonat Monohydrat 99,5-100,5% (Trockenmasse), EMPROVE® ESSENTIAL Ph. Eur., BP, NF, E500, SAFC®
Artikel-Nr:
(PRSI33-409)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-409
Lokale Artikelnummer::
PRSI33-409
Beschreibung:
This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI34-114)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-114
Lokale Artikelnummer::
PRSI34-114
Beschreibung:
This antibody is specific to Insulin-like Growth Factor (IGF1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI33-068)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-068
Lokale Artikelnummer::
PRSI33-068
Beschreibung:
This antibody recognises a protein of 36 kDa, identified as Cyclin D1. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms and a key cell cycle regulator. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. Cyclin D1 antibody is useful in identifying mantle cell lymphomas, which stain positive, from CLL/SLL and follicular lymphomas, which stain negative. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-363)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-363
Lokale Artikelnummer::
PRSI28-363
Beschreibung:
HOXC9 belongs to the homeobox family. The homeobox family is a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-960)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-960
Lokale Artikelnummer::
PRSI28-960
Beschreibung:
HOXC9 belongs to the homeobox family. The homeobox family is a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12.
VE:
1 * 100 µG
Lieferant:
Thermo Scientific
Beschreibung:
tert-Butylmethylether für die HPLC
Artikel-Nr:
(BOSSBS-2803R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2803R-FITC
Lokale Artikelnummer::
BOSSBS-2803R-FITC
Beschreibung:
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.
VE:
1 * 100 µl
Artikel-Nr:
(SERA39767.01)
Lieferant:
Serva
Hersteller-Artikelnummer::
39767.01
Lokale Artikelnummer::
SERA39767.01
Beschreibung:
di-Kaliumhydrogenphosphat
VE:
1 * 250 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
Alfa Aesar
Beschreibung:
di-Kaliumhydrogenphosphat, getrocknet 98+%
Artikel-Nr:
(SIAL435422-250ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
435422-250ML
Lokale Artikelnummer::
SIAL435422-250ML
Beschreibung:
Hard and soft surface cleaners, defoamers in coatings and water treatment. Lubricant in metal working, anti-foaming aid and extender for linear and cross-linked polyesters and polyurethanes.
VE:
1 * 250 mL
Lieferant:
CHROMACOL
Beschreibung:
* Das Modell 548-1146 ist die einzige Bördelkappe, die für 548-1183-Fläschchen empfohlen wird. Verwenden Sie alternativ bitte die Modelle 548-1151 (ideal für Einmal-Injektionen).
Artikel-Nr:
(PRSI27-457)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-457
Lokale Artikelnummer::
PRSI27-457
Beschreibung:
HOXC4 belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, are co-transcribed in a primary transcript. Subsequent processing results in gene-specific transcripts, which sometimes share a 5' non-coding exon.
VE:
1 * 100 µG
Lieferant:
Sigma-Aldrich
Beschreibung:
PEG-PPG-PEG (Pluronic P123) symmetric triblock copolymer constitutes of poly(ethylene oxide)(PEO) and poly (propylene oxide) (PPO).
Lieferant:
Bernd Kraft
Beschreibung:
tert-Butylmethylether analytisches Reagens
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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