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1,2-Dibromethan
Artikel-Nr:
(BOSSBS-12332R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12332R-A350
Lokale Artikelnummer::
BOSSBS-12332R-A350
Beschreibung:
Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis (1–3). Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation (1). Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases (4). Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions (4). Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome (1,5). Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus (4). Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland (1). The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively (4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11769R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R-A488
Lokale Artikelnummer::
BOSSBS-11769R-A488
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11512R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11512R-A350
Lokale Artikelnummer::
BOSSBS-11512R-A350
Beschreibung:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11512R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11512R-A680
Lokale Artikelnummer::
BOSSBS-11512R-A680
Beschreibung:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterised by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11843R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11843R-CY5
Lokale Artikelnummer::
BOSSBS-11843R-CY5
Beschreibung:
Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1).
VE:
1 * 100 µl
Artikel-Nr:
(FLUO018460-10G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
018460-10G
Lokale Artikelnummer::
FLUO018460-10G
Beschreibung:
3-Chlor-o-xylol
VE:
1 * 10 g
 This is a MarketSource item. Additional charges may apply
Lieferant:
DELTALAB
Beschreibung:
Vented petri dishes made from PS.
Artikel-Nr:
(ELGACT3)
Lieferant:
ELGA LabWater
Hersteller-Artikelnummer::
CT3
Lokale Artikelnummer::
ELGACT3
Beschreibung:
These disinfectant tablets sanitises tubing or pipe work to remove bacteria, reduce bio film and protect the system against bacterial growth.
VE:
1 * 12 ST
Artikel-Nr:
(510-1982)
Lieferant:
Retsch GmbH
Hersteller-Artikelnummer::
32.902.0001
Lokale Artikelnummer::
RETS32.902.0001
Beschreibung:
Diese Accessoires wurden entwickelt, um schwer trennbare Produkte, die nicht nass gesiebt werden können, zu separieren.
VE:
1 * 10 ST
Lieferant:
Sigma-Aldrich
Beschreibung:
Dipropyldisulfid, Sigma-Aldrich®
Artikel-Nr:
(BOSSBS-11571R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11571R-A680
Lokale Artikelnummer::
BOSSBS-11571R-A680
Beschreibung:
The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11571R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11571R-A750
Lokale Artikelnummer::
BOSSBS-11571R-A750
Beschreibung:
The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.
VE:
1 * 100 µl
Lieferant:
Sigma-Aldrich
Beschreibung:
5-Brom-1,3-benzodioxol, Sigma-Aldrich®
Artikel-Nr:
(BOCH8231)
Lieferant:
BOCHEM
Hersteller-Artikelnummer::
8231
Lokale Artikelnummer::
BOCH8231
Beschreibung:
Rack, made of stainless steel 18/10.
VE:
1 * 1 ST
Lieferant:
Mettler - Toledo
Beschreibung:
Robuste und wirtschaftliche Elektroden, einfache Handhabung.
Artikel-Nr:
(214-0386)
Lieferant:
DWK Life Sciences
Hersteller-Artikelnummer::
292040406
Lokale Artikelnummer::
SCOT292040406
Beschreibung:
Octagonal PE stoppers.
VE:
1 * 10 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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