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1,4-Benzenedimethanethiol
Artikel-Nr:
(BOSSBS-8995R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8995R
Lokale Artikelnummer::
BOSSBS-8995R
Beschreibung:
The genes encoding type I interferons (IFNs), which include 14 IFN-alphagenes (two of which are IFN-alpha1 and IFN-alpha13), one IFN-∫ gene, one IFN-w (also known as IFN-alpha II1) gene and a number of IFN-w pseudogenes, are clustered on human chromosome 9. IFN-alpha and -beta are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-alpha, IFN-beta or IFN-gamma, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-alphaR) interacts with IFN-alpha, IFN-beta and IFN-w, and seems to be a multisubunit receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13508R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13508R-A750
Lokale Artikelnummer::
BOSSBS-13508R-A750
Beschreibung:
G2A (for G2 accumulation) is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress (1). G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells (1,2). G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation (3). Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition (1,4). G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties (5). The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3009R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3009R-A555
Lokale Artikelnummer::
BOSSBS-3009R-A555
Beschreibung:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5216R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5216R-CY7
Lokale Artikelnummer::
BOSSBS-5216R-CY7
Beschreibung:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0490R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0490R
Lokale Artikelnummer::
BOSSBS-0490R
Beschreibung:
Protein phosphatase that is involved in many processes such as microtubule organisation at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-14 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyses RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5219R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5219R-A750
Lokale Artikelnummer::
BOSSBS-5219R-A750
Beschreibung:
Bad is a member of the Bcl2 family and acts to promote apoptosis by forming heterodimers with the survival proteins Bcl2 and BclxL, thus preventing them from binding with BAX. Bad is found on the outer mitochondrial membrane and, once phosphorylated in response to growth stimuli, translocates to the cytoplasm. The phosphorylation status of Bad represents a key checkpoint for death or cell survival. JNK-induced phosphorylation of BAD serine 128 promotes the apoptotic role of Bad by opposing the inhibitory effect of growth factor on Bad-mediated apoptosis. Cdc2-induced phosphorylation of Bad serine 128 has an inhibitory effect on its interaction with 14-3-3 proteins. The latter interaction is critical for Bad phosphorylation at serine 155, a site within the BH3 domain that leads to the release of BclxL and the promotion of cell survival. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2562R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2562R-CY7
Lokale Artikelnummer::
BOSSBS-2562R-CY7
Beschreibung:
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0490R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0490R-A555
Lokale Artikelnummer::
BOSSBS-0490R-A555
Beschreibung:
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-14 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11480R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11480R-CY7
Lokale Artikelnummer::
BOSSBS-11480R-CY7
Beschreibung:
Semaphorins are a family of cell surface and secreted proteins involved in neural development that are conserved from insects to humans. Members of this family are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin†domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. The transmembrane semaphorins are characterized by an additional 80 amino acid transmembrane domain and an 80-110 amino acid cytoplasmic domain. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA3E is a secreted semaphorin with 775 amino acids. Mutations in the SEMA3E gene are associated with CHARGE syndrome, a disorder characterized by cranial nerve dysfunction, coloboma of the eye, choanal atresia, inner and external ear abnormalities, cardiac anomalies, genitourinary abnormalities, and growth retardation.
VE:
1 * 100 µl
Artikel-Nr:
(265005-100)
Lieferant:
Merck Millipore (Calbiochem)
Hersteller-Artikelnummer::
265005-100
Lokale Artikelnummer::
CALB265005-100
Beschreibung:
Dexamethason, Millipore®
VE:
1 * 100 mg
Artikel-Nr:
(1.00383.9025)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.00383.9025
Lokale Artikelnummer::
MERP1.00383.9025
Beschreibung:
DL-Aplfelsäure, EMPROVE® ESSENTIAL Ph. Eur., NF, FCC, E296, SAFC®
VE:
1 * 25 kg
Lieferant:
MENAI
Beschreibung:
α,α,α-Trifluor-2,5-diaminotoluol
Artikel-Nr:
(ABNOMAB6899)
Lieferant:
Abnova
Hersteller-Artikelnummer::
MAB6899
Lokale Artikelnummer::
ABNOMAB6899
Beschreibung:
Mouse monoclonal antibody raised against native CD8A.
VE:
1 * 100 µG
Artikel-Nr:
(MOLE16320764-1G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
16320764-1G
Lokale Artikelnummer::
MOLE16320764-1G
Beschreibung:
Dexamethason
VE:
1 * 1 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(WITG0.786.025)
Lieferant:
WITEG LABORTECHNIK
Hersteller-Artikelnummer::
0.786.025
Lokale Artikelnummer::
WITG0.786.025
Beschreibung:
Borosilikatglas 3.3
VE:
1 * 1 ST
Artikel-Nr:
(BACE4030374.0250)
Lieferant:
BACHEM BIOCHEMICA
Hersteller-Artikelnummer::
4030374.0250
Lokale Artikelnummer::
BACE4030374.0250
Beschreibung:
L(+)-Asparagin Monohydrat
VE:
1 * 250 g
This is a MarketSource item. Additional charges may apply
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
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