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3,5-Difluoro-4-methoxybenzoyl+chloride
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3,5-Difluoro-4-methoxybenzoyl+chloride
Artikel-Nr:
(BSBTPB9195)
Lieferant:
BosterBio
Hersteller-Artikelnummer::
PB9195
Lokale Artikelnummer::
BSBTPB9195
Beschreibung:
Polyclonal antibody for FKHR/FOXO1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. FKHR/FOXO1 information: Molecular Weight: 69662 MW; Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation; Tissue Specificity: Ubiquitous.
VE:
1 * 100 µG
Artikel-Nr:
(WITG2.135.008)
Lieferant:
WITEG LABORTECHNIK
Hersteller-Artikelnummer::
2.135.008
Lokale Artikelnummer::
WITG2.135.008
Beschreibung:
Chromatography column made of borosilicate glass with fused in sintered glass disc with ST-stopcock at the top with solid plug and screw-thread retaining nut, vacuum connection with drip tip and ST-cone at the bottom.
VE:
1 * 1 ST
Artikel-Nr:
(BOHLC365-40)
Lieferant:
Bohlender
Hersteller-Artikelnummer::
C365-40
Lokale Artikelnummer::
BOHLC365-40
Beschreibung:
Magnetrührstäbchen mit Magnetkern aus Samarium-Kobalt, gekapselt in PTFE. Die mit diesen Rührstäben übertragenen Drehmomente sind viermal größer als bei herkömmlichen Magnetrührstäbchen.
VE:
1 * 1 ST
Artikel-Nr:
(BIBB29BU/M)
Lieferant:
SciLabware
Hersteller-Artikelnummer::
29BU/M
Lokale Artikelnummer::
BIBB29BU/M
Beschreibung:
PYREX®,Borosilicate glass.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-1135R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-A555
Lokale Artikelnummer::
BOSSBS-1135R-A555
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1135R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1135R-HRP
Lokale Artikelnummer::
BOSSBS-1135R-HRP
Beschreibung:
c-Src tyrosine kinase plays a critical role in signal transduction downstream of growth factor receptors, integrins and G protein-coupled receptors. We used stable isotope labeling with amino acids in cell culture (SILAC) approach to identify additional substrates of c-Src tyrosine kinase in human embryonic kidney 293T cells. We have identified 10 known substrates and interactors of c-Src and Src family kinases along with 26 novel substrates. We have experimentally validated 4 of the novel proteins (NICE-4, RNA binding motif 10, FUSE-binding protein 1 and TRK-fused gene) as direct substrates of c-Src using in vitro kinase assays and cotransfection experiments. Significantly, using a c-Src specific inhibitor, we were also able to implicate 3 novel substrates (RNA binding motif 10, EWS1 and Bcl-2 associated transcription factor) in PDGF signaling. Finally, to identify the exact tyrosine residues that are phosphorylated by c-Src on the novel c-Src substrates, we designed custom peptide microarrays containing all possible tyrosine-containing peptides (312 unique peptides) and their mutant counterparts containing a Tyr -->Phe substitution from 14 of the identified substrates. Using this platform, we identified 34 peptides that are phosphorylated by c-Src. We have demonstrated that SILAC-based quantitative proteomics approach is suitable for identification of substrates of nonreceptor tyrosine kinases and can be coupled with peptide microarrays for high-throughput identification of substrate phosphopeptides.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI27-353)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-353
Lokale Artikelnummer::
PRSI27-353
Beschreibung:
OLIG2 is a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. OLIG2 is an essential regulator of ventral neuroectodermal progenitor cell fate. It is associated with T-cell acute lymphoblastic leukemia due to a chromosomal translocation t (14;21) (q11.2;q22). OLIG2 might play a role in learning deficits associated with Down syndrome.This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t (14;21) (q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-670)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-670
Lokale Artikelnummer::
PRSI29-670
Beschreibung:
CHGA is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. Its gene's product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
VE:
1 * 100 µG
Lieferant:
Alfa Aesar
Beschreibung:
6-Cyan-7-nitrochinoxalin-2,3-dion 98%
Lieferant:
Bohlender
Beschreibung:
Magnetrührstäbchen mit magnetischem Kern aus Alnico 5, eingekapselt in PTFE. Kreuzköpfe sind auf beiden Seiten vorhanden.
Lieferant:
HUPFER METALLWERKE
Beschreibung:
Drahtrost-Auflage aus Edelstahl, elektropoliert, bestehend aus Winkelprofilen 35×10×3,0 mm (1,4×0,4×0,12'') an der Längsseite. Quer verlaufende Ø 3,5-mm-Stäbe (0,14'') sind dazwischen im Abstand von 25 mm (1,0'') mit Verstärkungsstreben an der Unterseite aus Ø 3,5-mm-Stäben (0,14'') eingeschweißt.
Lieferant:
Sigma-Aldrich
Beschreibung:
3-Chloroperbenzoic acid has been used in the oxidation of N-p-tolylsulfinyl-(E)-1-phenylethylideneimine to N-p-tolylsulfonyl (E)-1-phenylethylideneimine using dichloromethane as a solvent.
Artikel-Nr:
(EHERXA13480000CY)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
XA13480000CY
Lokale Artikelnummer::
EHERXA13480000CY
Beschreibung:
Organic Standard, Fenitrothion (O,O-Dimethyl-O-4-nitro-m-tolylthiophosphat) 100 µg/ml in Cyclohexan, Packung: Glasflasche
VE:
1 * 1 mL
Artikel-Nr:
(EBRO1340-5800)
Lieferant:
EBRO
Hersteller-Artikelnummer::
1340-5800
Lokale Artikelnummer::
EBRO1340-5800
Beschreibung:
Robust pH tester for use in industrial process water, used water, rinsing water in washer-disinfectors, laboratories, food production and beverage production.
VE:
1 * 1 ST
Artikel-Nr:
(MOLEM76658647)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M76658647
Lokale Artikelnummer::
MOLEM76658647
Beschreibung:
di-Natrium-L(+)-tartrat Dihydrat
VE:
1 * 1 kg
 This is a MarketSource item. Additional charges may apply
Lieferant:
Serva
Beschreibung:
5-Brom-2'-deoxyuridin (Broxuridin)
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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