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Ethyl+1H-pyrrolo[2,3-c]pyridine-2-carboxylate
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Ethyl+1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 30-33 kDa, which is identified as CD20 (Workshop V; Code CD20.4). It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.
Artikel-Nr:
(BOSSBS-6015R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6015R-HRP
Lokale Artikelnummer::
BOSSBS-6015R-HRP
Beschreibung:
SNF2L, also known as SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1), SWI or ISWI, is a 1,054 amino acid protein that localizes to the nucleus and contains one helicase C-terminal domain, one helicase ATP-binding domain and two SANT domains. Expressed as multiple alternatively spliced isoforms, SNF2L exists as a component of the nucleosome-remodeling factor (NURF) complex where it helps to facilitate the ATP-dependent perturbation of chromatin structure and may also be involved in brain development and neurite outgrowth. The gene encoding SNF2L maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11641R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11641R-A555
Lokale Artikelnummer::
BOSSBS-11641R-A555
Beschreibung:
BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyze ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8386R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8386R-CY5
Lokale Artikelnummer::
BOSSBS-8386R-CY5
Beschreibung:
CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8386R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8386R-CY3
Lokale Artikelnummer::
BOSSBS-8386R-CY3
Beschreibung:
CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8386R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8386R-CY7
Lokale Artikelnummer::
BOSSBS-8386R-CY7
Beschreibung:
CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
VE:
1 * 100 µl
Lieferant:
Corning
Beschreibung:
Axygen® horizontal gel box is a high quality, full-featured unit designed for exceptional durability and efficiency. These gel boxes feature leak-free external gel casting, which allows the user to cast one gel outside of the box while another gel is running inside. Boxes from 7, 10, 15 and 20cm
Artikel-Nr:
(BOSSBS-11669R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11669R
Lokale Artikelnummer::
BOSSBS-11669R
Beschreibung:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF146 (RING finger protein 146), also known as Dactylidin, is a 359 amino acid protein that contains one RING-type zinc finger and one WWE domain. Via its RING-type zinc finger, RNF146 may play a role in transcriptional regulation and protein degradation events. Defects in the gene encoding RNF146 are associated with Alzheimer's disease (AD) and may lead to a higher risk of breast cancer. Two isoforms of RNF146 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(17-1082-01)
Lieferant:
Cytiva
Hersteller-Artikelnummer::
17-1082-01
Lokale Artikelnummer::
GEHE17-1082-01
Beschreibung:
Phenyl Sepharose™ High Performance is an aromatic hydrophobic interaction chromatography (HIC) medium, designed for intermediate and polishing step purification steps when high resolution has priority.
VE:
1 * 75 mL
Lieferant:
Biosensis
Beschreibung:
The Neurotrophin Antibody Kit contains a collection of sheep antibodies raised against BDNF, NGF, NT3 and NT4/5. The kit is completed with one vial of normal sheep IgG for use as negative control. This kit presents a cost-effective way to investigate neurotrophin protein expression and function by immunological techniques such as immunohistochemistry, ELISA, and inhibition of biological activity.
Artikel-Nr:
(BOSSBS-8688R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8688R-HRP
Lokale Artikelnummer::
BOSSBS-8688R-HRP
Beschreibung:
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13573R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13573R-FITC
Lokale Artikelnummer::
BOSSBS-13573R-FITC
Beschreibung:
ZBTB39 may be involved in transcriptional regulation. It belongs to the krueppel C2H2-type zinc-finger protein family and contains one BTB (POZ) domain and eight C2H2-type zinc fingers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11229R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11229R
Lokale Artikelnummer::
BOSSBS-11229R
Beschreibung:
OTUB1 is a 271 amino acid protein that contains one OTU (ovarian tumor) domain and belongs to the OTU family of predicted cysteine proteases. Expressed as two isoforms (one of which is present throughout the body and the other of which is present only in lymphoid tissues), OTUB1 functions as a hydrolase that can remove ubiquitin residues from target proteins, thereby preventing protein degradation and playing an important role in protein turnover. OTUB1 interacts with GRAIL and, via this interaction, plays a role in the regulation and the induction of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to their cognate antigens. Due to its interaction with GRAIL, OTUB1 is an important regulator of immune responses in secondary lymphoid organs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11446R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11446R-A680
Lokale Artikelnummer::
BOSSBS-11446R-A680
Beschreibung:
BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11641R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11641R-HRP
Lokale Artikelnummer::
BOSSBS-11641R-HRP
Beschreibung:
BPTF is a 2,907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyze ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11641R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11641R-A750
Lokale Artikelnummer::
BOSSBS-11641R-A750
Beschreibung:
BPTF is a 2907 amino acid protein encoded by the human gene BPTF. BPTF belongs to the PBTF family and contains one bromodomain, one DDT domain and two PHD-type zinc fingers. BPTF acts as a histone-binding component of NURF (nucleosome-remodeling factor). The NURF complex, which consists of SMARCA1, BPTF, RbAp46 and RbAp48, acts to catalyse ATP-dependent nucleosome sliding and facilitates transcription of chromatin. It specifically recognizes histone H3 tails trimethylated on 'Lys-4' (H3-K4Me3), which mark transcription start sites of virtually all active genes. BPTF may also help regulate transcription through direct binding to DNA or transcription factors.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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