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1,4-Dithian-2,5-diol
Artikel-Nr:
(PRSI31-057)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-057
Lokale Artikelnummer::
PRSI31-057
Beschreibung:
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif.Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Lieferant:
LABCONCO
Beschreibung:
Zubehör für Gefriertrockner, Clear acrylic chamber for bulk drying, with lid, 345×427 mm, for Freezone® 1, 2,5, 4,5, 6, 8, 12 and 18
Artikel-Nr:
(PRSI4317)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4317
Lokale Artikelnummer::
PRSI4317
Beschreibung:
TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
VE:
1 * 100 µG
Lieferant:
Alfa Aesar
Beschreibung:
(2-Methoxyethoxy)methylchlorid ≥94%
Lieferant:
Thermo Fisher Scientific
Beschreibung:
Silikon, Platin-vernetzt.
Artikel-Nr:
(29548.053)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRF29548.053
Beschreibung:
Eine Auswahl von Schlüsseln zum Öffnen von IBC, 200 Liter-Fässern sowie Flaschen und anderen Containern mit DIN 32-, 45- 54- und 80-Verschlüssen.
VE:
1 * 1 ST
Lieferant:
AGILENT
Beschreibung:
MVP RNA is application-ready RNA available in small economical pack sizes.
Lieferant:
Thermo Scientific
Beschreibung:
1-Benzyl-3-pyrroline 97%
Lieferant:
Alfa Aesar
Beschreibung:
2,3-Diphenylmaleinsäureanhydrid ≥98%
Lieferant:
VWR Collection
Beschreibung:
By using the direct displacement method, these tips work well for infectious and volatile liquids, as the fluid never will get in touch with the instrument which avoids any contamination.
Artikel-Nr:
(SARSSBK25)
Lieferant:
BIOMIRE
Hersteller-Artikelnummer::
SARSSBK25
Lokale Artikelnummer::
BMRESARSSBK25
Beschreibung:
Dieser COV-Hygiene Xpress Nachweis Kit für den Nachweis von SARS CoV-2 auf Oberflächen und in Flüssigkeiten zeigt schnell ein Ergebnis und ist sofort anwendbar.
VE:
1 * 25 Assays
Lieferant:
Alfa Aesar
Beschreibung:
1-Benzyl-3-pyrroline 98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Mal-amido-PEG8-acid
Artikel-Nr:
(8.07994.0250)
Lieferant:
Merck
Hersteller-Artikelnummer::
8.07994.0250
Lokale Artikelnummer::
MERC8.07994.0250
Beschreibung:
3-Sulfolen, Sigma-Aldrich®
VE:
1 * 250 g
Artikel-Nr:
(BOSSBS-3237R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3237R-A750
Lokale Artikelnummer::
BOSSBS-3237R-A750
Beschreibung:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. In turn, these complexes regulate genes encoding molecules involved in B-cell survival and lymphoid organogenesis. Participates also in the negative feedback of the non-canonical NF-kappa-B signaling pathway by phosphorylating and destabilising MAP3K14/NIK. Within the nucleus, phosphorylates CREBBP and consequently increases both its transcriptional and histone acetyltransferase activities. Modulates chromatin accessibility at NF-kappa-B-responsive promoters by phosphorylating histones H3 at 'Ser-10' that are subsequently acetylated at 'Lys-14' by CREBBP. Additionally, phosphorylates the CREBBP-interacting protein NCOA3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A488
Lokale Artikelnummer::
BOSSBS-4985R-A488
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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