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4\'-(Dimethylamino)biphenyl-3-carbonsäure
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4\'-(Dimethylamino)biphenyl-3-carbonsäure
Artikel-Nr:
(BOSSBS-5304R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5304R-CY5
Lokale Artikelnummer::
BOSSBS-5304R-CY5
Beschreibung:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11067R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11067R-CY7
Lokale Artikelnummer::
BOSSBS-11067R-CY7
Beschreibung:
Beta-tectorin is a 329 amino acid secreted protein that contains one zona pellucida (ZP) domain. While it may form homomeric filaments after self-association, Beta-tectorin may also form heteromeric filaments when it associates with ?tectorin. The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia and proteolytically released into the extracellular compartment. Beta-tectorin is one of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8697R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8697R
Lokale Artikelnummer::
BOSSBS-8697R
Beschreibung:
Connexin 29 belongs to the connexin family and is a member of the epsilon-type subfamily. Connexin 29 is a membrane bound, multi-pass protein also known as gap junction epsilon-1 protein. A connexon, consisting of connexin hexamers, is a membrane bound structure that is integral in the formation of a gap junction. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Connexin 29 expression is restricted to the central nervous system and is present in brain, spinal cord, and sciatic nerve samples. It has been suggested that connexin 29 in the mature CNS contributes minimally to gap junctional intercellular communication in oligodendrocyte cell bodies. Rather, connexin 29 is targeted to myelin where it, along with connexin 32, may contribute to connexin-mediated communication between adjacent layers of uncompacted myelin.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15434R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15434R
Lokale Artikelnummer::
BOSSBS-15434R
Beschreibung:
HD-PTP is a 1,636 amino acid protein encoded by the human gene PTPN23. HD-PTP belongs to the protein-tyrosine phosphatase family, non-receptor class subfamily. It contains one BRO1 domain, two TPR repeats and one tyrosine-protein phosphatase domain. The C-terminal region contains the PTP-like domain, whereas the N-terminal region contains the two TPR regions. These regions are homologous to the yeast protein, BRO1, which is involved in the mitogen-activated protein kinase signaling pathway. Similarly, HD-PTP is believed to act as a negative regulator of Ras-mediated mitogenic activity and is phosphorylated upon DNA damage, probably by ATM or ATR. HD-PTP protein is differentially modulated by two angiogenic growth factors. While Vascular Endothelial Growth Factor (VEGF) has no affect on protein levels, Fibroblast Growth Factor-2 (FGF-2) induces HD-PTP degradation via the proteasome system.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9152R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9152R
Lokale Artikelnummer::
BOSSBS-9152R
Beschreibung:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM50 (tripartite motif containing 50), also known as TRIM50A or E3 ubiquitin-protein ligase TRIM50, is a 487 amino acid cytoplasmic protein that functions as an E3 ubiquitin-protein ligase. Containing one RING-type zinc finger, a B30.2/SPRY domain and a single B box-type zinc finger, TRIM50 belongs to the TRIM/RBCC family and undergoes post-translational auto-ubiquitination. TRIM50 exists as two alternatively spliced isoforms, designated TRIM50 alpha and TRIM50 beta, and has the ability to form dimers and trimers. The gene encoding TRIM50 maps to human chromosome 7, which houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15199R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15199R-A680
Lokale Artikelnummer::
BOSSBS-15199R-A680
Beschreibung:
C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6938R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6938R-A680
Lokale Artikelnummer::
BOSSBS-6938R-A680
Beschreibung:
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6938R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6938R-FITC
Lokale Artikelnummer::
BOSSBS-6938R-FITC
Beschreibung:
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the one EBV antigen that is expressed in all EBV associated malignancies. It has long been thought to go undetected by the cell mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV related cancers.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11408R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11408R-A680
Lokale Artikelnummer::
BOSSBS-11408R-A680
Beschreibung:
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13726R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13726R-CY5
Lokale Artikelnummer::
BOSSBS-13726R-CY5
Beschreibung:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB6 (Protocadherin beta-6) is a 794 amino acid single pass transmembrane protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB6) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of the protein. PCDHB6 is likely a calcium-dependent cell adhesion protein that is involved in the maintenance of neural connections in the brain. Unlike most protocadherin-beta proteins, PCDHB6 has not one but two PXXP motifs within its cytoplasmic domain, suggesting a role in signal transduction cascade events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10150R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10150R-A680
Lokale Artikelnummer::
BOSSBS-10150R-A680
Beschreibung:
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyse the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9128R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9128R-A555
Lokale Artikelnummer::
BOSSBS-9128R-A555
Beschreibung:
CDCA7 is a nuclear protein without a known function, although its high homology with the transcription factor JPO2 or RAM2 suggests that it is also a transcription factor. CDCA7 is one of many target genes regulated by the c-Myc transcription factor. Overexpression of CDCA7 occurs in a significant proportion of cancers and it may play an important role in tumorigenesis. Normally it is periodically expressed in the cell cycle, peaking at the G1 to S phase transition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5927R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5927R-CY3
Lokale Artikelnummer::
BOSSBS-5927R-CY3
Beschreibung:
The protein encoded by ANP32C is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is divergent between PP32 and the protein encoded by this gene. This gene does not contain introns.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8539R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8539R-A647
Lokale Artikelnummer::
BOSSBS-8539R-A647
Beschreibung:
Luciferase from the firefly has become one of the more widely used reporter proteins for the study of gene expression. Luciferase catalyzes a bioluminescent reaction which requires the substrate luciferin as well as Mg2+ and ATP. Mixing these reagents with the cell extract containing luciferase, results in a flash of light that decays rapidly. This light can be detected by a luminometer. The total light emission is proportional to the luciferase activity of the sample.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9128R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9128R-CY3
Lokale Artikelnummer::
BOSSBS-9128R-CY3
Beschreibung:
CDCA7 is a nuclear protein without a known function, although its high homology with the transcription factor JPO2 or RAM2 suggests that it is also a transcription factor. CDCA7 is one of many target genes regulated by the c-Myc transcription factor. Overexpression of CDCA7 occurs in a significant proportion of cancers and it may play an important role in tumorigenesis. Normally it is periodically expressed in the cell cycle, peaking at the G1 to S phase transition.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9128R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9128R-A680
Lokale Artikelnummer::
BOSSBS-9128R-A680
Beschreibung:
CDCA7 is a nuclear protein without a known function, although its high homology with the transcription factor JPO2 or RAM2 suggests that it is also a transcription factor. CDCA7 is one of many target genes regulated by the c-Myc transcription factor. Overexpression of CDCA7 occurs in a significant proportion of cancers and it may play an important role in tumorigenesis. Normally it is periodically expressed in the cell cycle, peaking at the G1 to S phase transition.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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