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1,2,3,4-Tetrahydroquinoline-6-carbonitrile
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1,2,3,4-Tetrahydroquinoline-6-carbonitrile
Artikel-Nr:
(BOSSBS-0260R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0260R-A750
Lokale Artikelnummer::
BOSSBS-0260R-A750
Beschreibung:
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognise different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3492R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3492R-A350
Lokale Artikelnummer::
BOSSBS-3492R-A350
Beschreibung:
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway.
VE:
1 * 100 µl
Artikel-Nr:
(PRSI26-346)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-346
Lokale Artikelnummer::
PRSI26-346
Beschreibung:
POLR1D belongs to the archaeal rpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR1D is the common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI33-013)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-013
Lokale Artikelnummer::
PRSI33-013
Beschreibung:
Thyrotropin-releasing hormone (TRH) is produced by tissues of the nervous system and to a lesser degree, pancreas, testis, adrenal gland and lymphoid organs. There are two types of TRH in rodents, TRH1 and 2, but only TRH1 in humans. In cells of the nervous system, it is a neurotransmitter, acting via its receptor, TRH receptor, to stimulate phosphoinositide-specific phospholipase C, which stimulates phosphatidylinositol hydrolysis to form inositol triphosphate.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI90-365)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-365
Lokale Artikelnummer::
PRSI90-365
Beschreibung:
NAD kinase catalyses the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. NAD kinase from <i>Mycobacterium tuberculosis</i> is not ATP-dependent but has a broader substrate specificity than human NAD kinase. It can economically produce NADP+ by using other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Was identified as a high-confidence drug target. Catalytic activity: ATP + NAD+ = ADP + NADP+.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-364)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-364
Lokale Artikelnummer::
PRSI90-364
Beschreibung:
NAD kinase catalyses the transfer of a phosphate group from ATP to NAD+ to generate NADP+, which in its reduced form acts as an electron donor for biosynthetic reactions. NADP+ is an essential coenzyme in metabolism and provides reducing power to biosynthetic processes such as fatty acid biosynthesis. NAD kinase from <i>Bacillus subtilis</i> is not ATP-dependent but has a broader substrate specificity than human NAD kinase. It can economically produce NADP+ by using other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Catalytic activity: ATP + NAD+ = ADP + NADP+.
VE:
1 * 50 µG
Artikel-Nr:
(733-1271)
Lieferant:
Quantabio
Hersteller-Artikelnummer::
95062-01K
Lokale Artikelnummer::
QUNT95062-01K
Beschreibung:
Die dNTP-Mischung (10 mM) ist eine Lösung von hochreinen Desoxyribonukleosidtriphosphaten, die funktional für die quantitative Echtzeit-PCR (qPCR) qualifiziert wurde. Sie eignet sich für konventionelle Endpunkt-PCR, Echtzeit-qPRC, Erststrang-cDNA-Synthese sowie andere Anwendungen, die dNTP als Substrat erfordern. Der Einsatz von qPCR-zertifizierten dNTPs ist eine einfache, aber wichtige Maßnahme zur Sicherstellung einer konsistenten Assayleistung.
VE:
Artikel-Nr:
(SARS06.1690.001)
Lieferant:
SARSTEDT
Hersteller-Artikelnummer::
06.1690.001
Lokale Artikelnummer::
SARS06.1690.001
Beschreibung:
Präparierung mit Tri-Natriumcitrat-Lösung zur venösen Blutentnahme.
VE:
1 * 500 ST
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PRSI5877)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5877
Lokale Artikelnummer::
PRSI5877
Beschreibung:
SESTD1 Antibody: SESTD1 was initially identified in mutant zebrafish with defects in the spontaneous contraction and touch response as a novel gene, solo, encoding a protein containing SEC14 and spectrin repeat domains. Other experiments indicated that SESTD1 interacts with the TRPC4 and TRPC5, members of the transient receptor potential channel family, via the TRPC calmodulin- and inositol 1, 4, 5-triphosphate receptor-binding domain and is essential for efficient receptor-mediated activation of TRPC5, suggesting that SESTD1 is a novel regulator of these TRPC proteins.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI30-455)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-455
Lokale Artikelnummer::
PRSI30-455
Beschreibung:
POLR3B belongs to the RNA polymerase beta chain family. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3B is the second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
VE:
1 * 50 µG
Lieferant:
Spectrum Chemical
Beschreibung:
Calcium phosphate tribasic, Pulver NF
Lieferant:
Thermo Scientific
Beschreibung:
tri-Calciumphosphat (35 - 40% Ca) zur Analyse
Lieferant:
Sigma-Aldrich
Beschreibung:
tri-Calciumphosphat, Sigma-Aldrich®
Lieferant:
MP Biomedicals
Beschreibung:
Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction and intracellular signal transduction (cGMP). When guanine is attached by its N9 nitrogen to the C1 carbon of adeoxyribose ring it is known as deoxyguanosine.
Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein. The antiviral drug aciclovir, often used in herpes treatment, is structurally similar to guanosine.
Lieferant:
Merck
Beschreibung:
Calciumphosphat, EMPROVE® EXPERT Ph. Eur., BP, E341 geeignet für die Verwendung als Trägerstoff, SAFC®
Artikel-Nr:
(D5143-25G)
Lieferant:
SIGMA ALDRICH MICROSCOPY
Hersteller-Artikelnummer::
D5143-25G
Lokale Artikelnummer::
SIAMD5143-25G
Beschreibung:
N,N-Diethyl-p-phenylenediamine oxalate salt, (4-Amino-N,N-diethylaniline oxalate salt)
VE:
1 * 25 g
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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