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2-(Diethylamino)benzonitrile
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2-(Diethylamino)benzonitrile
Artikel-Nr:
(BOSSBS-9689R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9689R-A488
Lokale Artikelnummer::
BOSSBS-9689R-A488
Beschreibung:
TWA1 is a 228 amino acid nuclear protein that is highly conserved throughout evolution. TWA1 interacts with Ran BP-M, a protein that is implicated in a diverse array of cellular processes including DNA replication, entry into and exit from mitosis, and the transport of RNA and proteins through the nuclear pore complex. Together, Ran BP-M and TWA1 form a complex with cytoplasmic Muskelin, a mediator of cell spreading. It is thought that this complex plays a role in the Ran GTPase cycle and therefore a potential role in the cell cycle. TWA1 contains a LisH-CTLH motif which is usually found in proteins that are involved in nucleokinesis, chromosome segregation, cell migration and microtubule dynamics. The gene encoding TWA1 maps to human chromosome 20, which comprises approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Artikel-Nr:
(BOSSBS-12060R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12060R-A555
Lokale Artikelnummer::
BOSSBS-12060R-A555
Beschreibung:
Cyclin Y is a 341 amino acid protein belonging to the cyclin family. Cyclin Y exists as three alternatively spliced isoforms and contains a cyclin N-terminal domain. Cyclin Y may control cell division cycles and regulate cyclin-dependent kinases.Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T, Y and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle, thereby regulating kinase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6936R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6936R-A680
Lokale Artikelnummer::
BOSSBS-6936R-A680
Beschreibung:
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterised family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11195R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11195R-A680
Lokale Artikelnummer::
BOSSBS-11195R-A680
Beschreibung:
BAF53b is a member of a family of actin-related proteins (ARPs), which shares significant sequence identity with conventional actins. Both actins and ARPs comprise an actin fold, which forms an ATP binding cleft. BAF53b is a component of the BAF (BRG/brm-associated factor) complex in mammals, which is functionally related to the SWI/SNF complex in S. cerevisiae and Drosophila, and is associated with chromatin remodeling to facilitate transcriptional activation. As neural progenitors exit the cell cycle, the highly homologous BAF53a subunit of the BAF complex is replaced by BAF53b. This subunit switch is essential for the transition from neural stem cells/progenitors to postmitotic neurons. BAF53b also plays a role in dendritic outgrowth, during which it is required to recruit the BAF complex and the dendritic regulator CREST to specific gene promoters. This function can not be performed by BAF53a.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13578R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13578R-A647
Lokale Artikelnummer::
BOSSBS-13578R-A647
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger and BTB domain-containing protein 43 (ZBTB43), also known as ZNF297B or ZBTB22B, is a 467 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZBTB43 contains a BTB domain, also known as a POZ domain, which inhibits DNA binding and mediates homotypic and heterotypic dimerization. Characteristics of the BTB domain and the interaction of ZBTB43 with BDP1 suggest that ZBTB43 functions as a transcription regulator.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11349R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11349R-A680
Lokale Artikelnummer::
BOSSBS-11349R-A680
Beschreibung:
Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the carbonic anhydrase family encode either active carbonic anhydrase isozymes or _catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4636R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4636R-A680
Lokale Artikelnummer::
BOSSBS-4636R-A680
Beschreibung:
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and oestrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and foetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9376R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9376R-FITC
Lokale Artikelnummer::
BOSSBS-9376R-FITC
Beschreibung:
MuRF1, is a nuclear protein that interacts with SMT3b and the large myofibrillar protein Titin. In muscle cells, MuRF2 (RFN29) regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including Titin and Myosin. MuRF3, also designated tripartite motif-containing 54 (TRIM54) or ring finger protein 30 (RNF30), interacts with tubulin and stabilizes microtubules duing myotube formation. It is a cytoplasmic protein the localizes to the Z-lines in skeletal muscles, while MuRF2 localizes to the sarcomeric M-band in cardiomyocytes. MuRF3 shares 77% and 65% sequence identity with MuRF1 and MuRF2, respectively. MuRF1-3 share a conserved N-terminal RING domain and zinc-binding B-box motif, and two coiled-coil dimerization motif boxes, in their central regions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11195R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11195R-A647
Lokale Artikelnummer::
BOSSBS-11195R-A647
Beschreibung:
BAF53b is a member of a family of actin-related proteins (ARPs), which shares significant sequence identity with conventional actins. Both actins and ARPs comprise an actin fold, which forms an ATP binding cleft. BAF53b is a component of the BAF (BRG/brm-associated factor) complex in mammals, which is functionally related to the SWI/SNF complex in S. cerevisiae and Drosophila, and is associated with chromatin remodelling to facilitate transcriptional activation. As neural progenitors exit the cell cycle, the highly homologous BAF53a subunit of the BAF complex is replaced by BAF53b. This subunit switch is essential for the transition from from neural stem cells / progenitors to postmitotic neurons. BAF53b also plays a role in dendritic outgrowth, during which it is required to recruit the BAF complex and the dendritic regulator CREST to specific gene promoters. This function can not be performed by BAF53a.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13574R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13574R-A750
Lokale Artikelnummer::
BOSSBS-13574R-A750
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZBTB4 (zinc finger and BTB domain containing 4), also known as KAISO-L1 (KAISO-like zinc finger protein 1), is a 1,013 amino acid nuclear protein that is involved in transcriptional regulation. ZBTB4 contains one BTB (POZ) domain, six C2H2-type zinc fingers and is phosphorylated and downregulated by HIPK2. The gene encoding ZBTB4 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11349R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11349R-A555
Lokale Artikelnummer::
BOSSBS-11349R-A555
Beschreibung:
Carbonic anhydrases (CAs), also designated carbonate dehydratases or carbonate hydrolyases, form a large family of genes that encode zinc metalloenzymes of great physiologic importance. As catalysts of the reversible hydration of carbon dioxide, these enzymes participate in a variety of biologic processes, including respiration, acid-base balance, bone resorption and calcification as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. Genes in the ?carbonic anhydrase family encode either active carbonic anhydrase isozymes or æ³catalytic?(devoid of CO2 hydration activity) carbonic anhydrase-related proteins. Human CA I (CA1) is encoded by the CA1 gene, which maps to a region on chromosome 8 that harbors a cluster of CA genes. CA I localizes to the cytoplasm and research indicates that a severe deficiency of CA I does not result in any obvious hematological or renal consequences.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13574R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13574R-A555
Lokale Artikelnummer::
BOSSBS-13574R-A555
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZBTB4 (zinc finger and BTB domain containing 4), also known as KAISO-L1 (KAISO-like zinc finger protein 1), is a 1,013 amino acid nuclear protein that is involved in transcriptional regulation. ZBTB4 contains one BTB (POZ) domain, six C2H2-type zinc fingers and is phosphorylated and downregulated by HIPK2. The gene encoding ZBTB4 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6936R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6936R-A488
Lokale Artikelnummer::
BOSSBS-6936R-A488
Beschreibung:
Differentiation of myogenic cells is regulated by multiple positively and negatively acting factors. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development include Myo D, myogenin, Myf-5 and Myf-6 (also designated MRF-4 or herculin). Of interest, most muscle cells express either Myo D or Myf-5 in the committed state, but when induced to differentiate, all turn on expression of myogenin. Myo D transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, IF2 and HEB. Myo D-E heterodimers bind avidly to consensus (CANNTG) E box target sites that are functionally important elements in the upstream regulatory sequences of many muscle-specific terminal differentiation genes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6895R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6895R-A488
Lokale Artikelnummer::
BOSSBS-6895R-A488
Beschreibung:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9055R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9055R-A488
Lokale Artikelnummer::
BOSSBS-9055R-A488
Beschreibung:
DR1, also known as NC2∫ (negative cofactor 2 subunit ∫), is a TFIID (TATA box-binding protein)-associated protein. DR1 localizes to the nucleus and contains an N-terminal histone fold motif, a TFIID-binding domain and an alanine and glutamine rich region. Via its histone fold motif, DR1 forms a heterodimer with NC2å (DRAP1) to comprise the conserved eukaryotic complex, NC2 (negative cofactor 2). The NC2 complex can both positively and negatively regulate transcription by RNA Pol II. More specifically, NC2 acts as a repressor of TATA-dependent transcription and acts as an activator for DPE-dependent transcription. NC2 represses RNA Pol II transcription by binding to TFIID and inhibiting association of the transcription factors TFIIA and TFIIB. NC2 activity is regulated by phosphorylation. Both subunits, NC2å and DR1, are phosphorylated in vivo.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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